Targets — browse / sort / filter (view)

One row per human protein target with names + key evidence. Click column headers to SORT; use the facets to FILTER (tier, activation pair, known aptamer, EV-Map). UniProt IDs link to the source.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

id
UniProt accession (human). Links to uniprot.org.
gene_symbol
Gene symbol (e.g. ITGB3).
protein_name
Protein name (UniProt).
tier
Tier 1 = PDB-anchored; Tier 1.5 = AlphaFold-confident.
priority_score
Composite prioritisation = 0.30*biology + 0.30*reagent-gap + 0.20*druggability + 0.10*disease + 0.10*novelty. Sub-scores are assigned during LLM-assisted curation — a heuristic ranking, NOT an experimental measurement.
has_activation_state_pdb_pair
1 if a curated ACTIVE/INACTIVE PDB pair exists (only 11 targets).
in_cev_map
1 if in the EV-Map circulating-EV proteome (Rai 2025); 3,422 targets.
has_known_aptamer
1 if aptamer evidence found in PubMed/Aptagen (1,472 targets).
opentargets_top_disease_score
Open Targets association score (0-1).
aptamer_count_pubmed
Number of PubMed hits for this protein AND (aptamer OR SELEX).
aptamer_pmids
The actual PubMed IDs behind the aptamer evidence — click each to read the paper. This is the source of the 'has aptamer' claim.

397 rows where has_cryoEM = 0, has_known_aptamer = 1 and tier = "Tier 1.5" sorted by priority_score descending

✎ View and edit SQL

This data as json, CSV (advanced)

Suggested facets: pdb_count_total

in_cev_map 2

  • 0 211
  • 1 186

has_activation_state_pdb_pair 2

  • 0 396
  • 1 1

tier 1

  • Tier 1.5 · 397 ✖

has_known_aptamer 1

has_cryoEM 1

id gene_symbol protein_name tier priority_score ▲ pdb_count_total alphafold_mean_pLDDT has_cryoEM has_activation_state_pdb_pair activation_state_pdb_active activation_state_pdb_inactive drug_count_approved has_known_aptamer aptamer_count_pubmed aptamer_pmids in_cev_map opentargets_top_disease_name opentargets_top_disease_score
P15260 IFNGR1 Interferon gamma receptor 1 Tier 1.5 0.804 5 66.0 0 0       1 2 33667716 1 disseminated atypical mycobacterial infection 0.5414012388034828
P36888 FLT3 Receptor-type tyrosine-protein kinase FLT3 Tier 1.5 0.788 11 75.94 0 0       1 6 41733039, 34364920, 31434881, 30237882, 29299123, 22411871 1 acute myeloid leukemia 0.8313389209288576
P48023 FASLG Tumor necrosis factor ligand superfamily member 6 Tier 1.5 0.775 3 80.19 0 0       1 1 16581027 0 autoimmune lymphoproliferative syndrome type 1 0.6984292519156657
P02776 PF4 Platelet factor 4 Tier 1.5 0.77 10 75.06 0 0       1 10 33859620, 32366845, 31967847, 23847186, 23673861, 34248840, 32022468 1 systemic scleroderma 0.11523541376593864
Q9GZU2 PEG3 Paternally-expressed gene 3 protein Tier 1.5 0.75 1 44.53 0 0       1 1 16595502 0 neurodegenerative disease 0.34815912577489827
P18075 BMP7 Bone morphogenetic protein 7 Tier 1.5 0.749 4 76.19 0 0       1 1 30537181 0 Inguinal hernia 0.4420059023371716
Q9Y5C1 ANGPTL3 Angiopoietin-related protein 3 Tier 1.5 0.727 1 79.62 0 0       1 1 23770039 0 familial hypobetalipoproteinemia 2 0.6739043862507132
P41221 WNT5A Protein Wnt-5a Tier 1.5 0.71 0 87.69 0 0       1 4 40855286, 32693649, 22363130, 18673242 1 Robinow syndrome 0.7220360983378594
A0A0C5B5G6 MT-RNR1 Mitochondrial-derived peptide MOTS-c Tier 1.5 0.7 0 72.06 0 0       1 1 35311942 0    
P08620 FGF4 Fibroblast growth factor 4 Tier 1.5 0.7 1 81.5 0 0       1 3 35415885, 33536494, 7547864 0 cancer 0.6026669167438079
P19021 PAM Peptidyl-glycine alpha-amidating monooxygenase Tier 1.5 0.695 0 71.69 0 0       1 25 41855944, 41500123, 41384307, 41285544, 41222440, 40607956, 39929897, 39472107, 38867016, 38846799, 37977804, 37977780, 37906116, 37127012, 36905684, 35478209, 33911033, 33516855, 32315032, 32307868, 30399413, 30124431, 26406332, 22954359, 14965210 1 type 2 diabetes mellitus 0.5754371880839976
P21781 FGF7 Fibroblast growth factor 7 Tier 1.5 0.695 0 82.44 0 0       1 5 35415885, 15719578, 7547864, 16462265 0 cancer 0.5963369026823151
P10586 PTPRF Receptor-type tyrosine-protein phosphatase F Tier 1.5 0.69 13 82.0 0 0       1 4 42101929, 39087949, 36594741 1 smoking initiation 0.4641111755355386
O00501 CLDN5 Claudin-5 Tier 1.5 0.685 0 83.75 0 0       1 1 18951306 1 genetic disorder 0.40861362787778505
P14384 CPM Carboxypeptidase M Tier 1.5 0.68 1 90.31 0 0       1 3 38876068, 38060303, 36768220 1 hydronephrosis 0.3163273148871551
P26718 KLRK1 NKG2-D type II integral membrane protein Tier 1.5 0.679 22 79.19 0 0       1 1 24629635 0 Behcet's syndrome 0.18614538678991077
P09758 TACSTD2 Tumor-associated calcium signal transducer 2 Tier 1.5 0.673 7 82.69 0 0       1 4 41384307, 41241473, 40050871, 39250993 1 gelatinous drop-like corneal dystrophy 0.7293087728162646
P98066 TNFAIP6 Tumor necrosis factor-inducible gene 6 protein Tier 1.5 0.671 5 81.12 0 0       1 1 39263947 1 type 2 diabetes mellitus 0.30862220597837015
O95750 FGF19 Fibroblast growth factor 19 Tier 1.5 0.668 4 79.81 0 0       1 4 35415885, 31967847, 27679852 0 cancer 0.38540691230511315
O00744 WNT10B Protein Wnt-10b Tier 1.5 0.668 0 80.06 0 0       1 2 32810272, 18673242 0 Split hand-split foot malformation 0.7755225395358214
Q9HCK4 ROBO2 Roundabout homolog 2 Tier 1.5 0.665 6 67.38 0 0       1 2 40616090, 31640794 0 familial vesicoureteral reflux 0.6460375744556555
Q6PCB0 VWA1 von Willebrand factor A domain-containing protein 1 Tier 1.5 0.664 0 78.38 0 0       1 4 41906877, 41693575, 38904251, 38299345 0 neuronopathy, distal hereditary motor, autosomal recessive 7 0.7420531156755253
A2RU14 TMEM218 Transmembrane protein 218 Tier 1.5 0.663 0 87.62 0 0       1 6 41360349, 34861273, 31349094, 29277631, 26580576, 26248137 0 Joubert syndrome 39 0.7308441626389979
P16870 CPE Carboxypeptidase E Tier 1.5 0.66 0 90.38 0 0       1 16 39863729, 39793371, 38861005, 36832010, 36773630, 27886773, 27219679, 25738486, 28706644, 24768847, 23875581, 22280349, 21419619, 20949139, 20491465, 19174227 1 BDV syndrome 0.7029731914682913
P18510 IL1RN Interleukin-1 receptor antagonist protein Tier 1.5 0.66 5 87.06 0 0       1 1 38928037 0 sterile multifocal osteomyelitis with periostitis and pustulosis 0.7734282711738736
Q86YL7 PDPN Podoplanin Tier 1.5 0.66 6 57.97 0 0       1 4 41304780, 41292412, 39451677 0 Microscopic hematuria 0.41183796492083136
P22692 IGFBP4 Insulin-like growth factor-binding protein 4 Tier 1.5 0.66 4 77.25 0 0       1 6 35323639, 32515246, 31930684 1 allergic rhinitis 0.35214760515440524
Q13433 SLC39A6 Zinc transporter ZIP6 Tier 1.5 0.66 0 60.44 0 0       1 1 40132409 1 breast cancer 0.11188167100061543
O15389 SIGLEC5 Sialic acid-binding Ig-like lectin 5 Tier 1.5 0.656 3 77.75 0 0       1 3 33584010, 27678199, 24405684 0 dentures 0.15815607474115415
Q9Y625 GPC6 Glypican-6 Tier 1.5 0.655 0 82.0 0 0       1 1 40093223 1 autosomal recessive omodysplasia 0.7503216726357611
P02766 TTR Transthyretin Tier 1.5 0.655 0 88.0 0 0       1 11 39737993, 32616928, 23770039, 21875107, 21314458, 39596348, 38399458, 36881759, 33572452 1 amyloidosis, hereditary systemic 1 0.846421986844374
Q9H0R3 TMEM222 Transmembrane protein 222 Tier 1.5 0.654 0 84.81 0 0       1 3 41643149, 36174865, 25998051 1 neurodevelopmental disorder with motor and speech delay and behavioral abnormalities 0.6449281600938256
O15263 DEFB4A Defensin beta 4A Tier 1.5 0.65 6 78.0 0 0       1 2 40362575, 32067984 0 ulcerative colitis 0.09865892368546408
P84996 GNAS Protein ALEX Tier 1.5 0.65 0 43.59 0 0       1 9 39154820, 37963924, 36037714, 34488577, 31129134, 30979095, 30682825, 29146902, 28626560 0    
P32942 ICAM3 Intercellular adhesion molecule 3 Tier 1.5 0.648 1 87.12 0 0       1 3 40650261, 34730968, 17660953 1 lymphatic system disease 0.28331776251399693
P01138 NGF Beta-nerve growth factor Tier 1.5 0.648 8 73.25 0 0       1 6 42015870, 38780008, 32982626, 21216401, 7545283, 29754498 0 hereditary sensory and autonomic neuropathy type 5 0.7785402119369383
Q2I0M5 RSPO4 R-spondin-4 Tier 1.5 0.646 0 78.56 0 0       1 3 38238732, 37425696 0 nonsyndromic congenital nail disorder 4 0.7604902779349189
Q9BQ51 PDCD1LG2 Programmed cell death 1 ligand 2 Tier 1.5 0.645 2 86.38 0 0       1 1 38928037 0 melanoma 0.42716921377769757
Q9UKP5 ADAMTS6 A disintegrin and metalloproteinase with thrombospondin motifs 6 Tier 1.5 0.644 0 77.5 0 0       1 1 35700850 0 Abnormality of the skeletal system 0.5444162515485208
Q14242 SELPLG P-selectin glycoprotein ligand 1 Tier 1.5 0.64 1 50.38 0 0       1 1 25979951 1 glaucoma 0.40058604767334977
P07202 TPO Thyroid peroxidase Tier 1.5 0.64 0 83.44 0 0       1 1 29881374 0 familial thyroid dyshormonogenesis 0.6710562308468054
P31994 FCGR2B Low affinity immunoglobulin gamma Fc region receptor II-b Tier 1.5 0.636 5 78.44 0 0       1 1 38928037 0 systemic lupus erythematosus 0.460465747544726
Q16674 MIA Melanoma-derived growth regulatory protein Tier 1.5 0.636 4 86.38 0 0       1 15 41768714, 40943389, 40444021, 38899488, 37853818, 35842727, 35593028, 35061691, 34038704, 32957732, 31878307, 31289496, 29499935, 28059418, 26840019 0 neurodegenerative disease 0.36367051545295126
P01732 CD8A T-cell surface glycoprotein CD8 alpha chain Tier 1.5 0.635 8 78.19 0 0       1 2 38487531, 36979667 1 progressive supranuclear palsy 0.2036023725502463
Q92563 SPOCK2 Testican-2 Tier 1.5 0.627 0 66.94 0 0       1 8 39695715, 35474272, 32958645, 28794177, 38656806, 36288905 0 Back pain 0.3687304175767662
P34810 CD68 Macrosialin Tier 1.5 0.627 0 73.19 0 0       1 4 37422510, 33321636, 28315675, 27940247 0 neurodegenerative disease 0.3710186480081222
P51884 LUM Lumican Tier 1.5 0.625 0 90.38 0 0       1 7 41744190, 36785906, 28453726, 26230699, 24180352, 23890607 1 lumbar disc herniation 0.3492311458288365
P49862 KLK7 Kallikrein-7 Tier 1.5 0.624 12 91.56 0 0       1 1 30114962 1 neurodegenerative disease 0.2420324965785189
P21926 CD9 CD9 antigen Tier 1.5 0.623 5 88.56 0 0       1 17 41999228, 41625383, 40618375, 39266887, 38866706, 38057814, 37585601, 37351166, 37019008, 36704890, 34647460, 34505435, 33304477, 32730952, 32207293, 28959386 1 diphtheria 0.5261379875719714
Q96NZ8 WFIKKN1 WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 Tier 1.5 0.621 2 78.06 0 0       1 1 33591955 0 neurodegenerative disease 0.3060887002952384

Next page

Advanced export

JSON shape: default, array, newline-delimited

CSV options: 

CREATE VIEW v_targets AS
SELECT f.id, n.gene_symbol, n.protein_name, tg.tier, f.priority_score,
 f.pdb_count_total, f.alphafold_mean_pLDDT, f.has_cryoEM,
 f.has_activation_state_pdb_pair, f.activation_state_pdb_active, f.activation_state_pdb_inactive,
 f.drug_count_approved, f.has_known_aptamer, f.aptamer_count_pubmed, ap.aptamer_pmids,
 f.in_cev_map, f.opentargets_top_disease_name, f.opentargets_top_disease_score
FROM v_target_full f
LEFT JOIN target_names n ON n.target_id=f.id
LEFT JOIN targets tg ON tg.id=f.id
LEFT JOIN target_aptamer_pmids ap ON ap.target_id=f.id;