Targets — browse / sort / filter (view)

One row per human protein target with names + key evidence. Click column headers to SORT; use the facets to FILTER (tier, activation pair, known aptamer, EV-Map). UniProt IDs link to the source.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

id
UniProt accession (human). Links to uniprot.org.
gene_symbol
Gene symbol (e.g. ITGB3).
protein_name
Protein name (UniProt).
tier
Tier 1 = PDB-anchored; Tier 1.5 = AlphaFold-confident.
priority_score
Composite prioritisation = 0.30*biology + 0.30*reagent-gap + 0.20*druggability + 0.10*disease + 0.10*novelty. Sub-scores are assigned during LLM-assisted curation — a heuristic ranking, NOT an experimental measurement.
has_activation_state_pdb_pair
1 if a curated ACTIVE/INACTIVE PDB pair exists (only 11 targets).
in_cev_map
1 if in the EV-Map circulating-EV proteome (Rai 2025); 3,422 targets.
has_known_aptamer
1 if aptamer evidence found in PubMed/Aptagen (1,472 targets).
opentargets_top_disease_score
Open Targets association score (0-1).
aptamer_count_pubmed
Number of PubMed hits for this protein AND (aptamer OR SELEX).
aptamer_pmids
The actual PubMed IDs behind the aptamer evidence — click each to read the paper. This is the source of the 'has aptamer' claim.

906 rows where has_cryoEM = 0, in_cev_map = 0 and tier = "Tier 1" sorted by priority_score descending

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has_known_aptamer 2

  • 0 663
  • 1 243

tier 1

  • Tier 1 · 906 ✖

in_cev_map 1

has_cryoEM 1

has_activation_state_pdb_pair 1

  • 0 906
id gene_symbol protein_name tier priority_score ▲ pdb_count_total alphafold_mean_pLDDT has_cryoEM has_activation_state_pdb_pair activation_state_pdb_active activation_state_pdb_inactive drug_count_approved has_known_aptamer aptamer_count_pubmed aptamer_pmids in_cev_map opentargets_top_disease_name opentargets_top_disease_score
P23946 CMA1 Chymase Tier 1 0.875 42 91.31 0 0       1 1 30572223 0 pernicious anemia 0.17348905136256007
Q9UJA9 ENPP5 Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 Tier 1 0.87 1 88.12 0 0       0 0   0 neurodegenerative disease 0.33211724272317855
Q31135 H2-Ab1   Tier 1 0.83 12 85.12 0 0       0 0   0    
P01236 PRL Prolactin Tier 1 0.795 12 85.56 0 0       1 6 40327044, 30834248, 29277631, 28263753, 27679852, 16947086 0 AL amyloidosis 0.4619748183558772
O14788 TNFSF11 Tumor necrosis factor ligand superfamily member 11 Tier 1 0.79 2 79.19 0 0       1 2 15562003, 41226313 0 osteoporosis 0.6957850224892792
A6ND01 IZUMO1R Sperm-egg fusion protein Juno Tier 1 0.773 7 87.38 0 0       0 0   0 placental retention 0.23306495563589497
A0A5H2UYS3 HLA-A   Tier 1 0.77 20 85.25 0 0       0 0   0    
P26951 IL3RA Interleukin-3 receptor subunit alpha Tier 1 0.767 4 85.25 0 0       1 3 40931580, 36171541, 31323275 0 acute myeloid leukemia 0.46904332714118013
P16471 PRLR Prolactin receptor Tier 1 0.747 12 61.03 0 0       0 0   0 familial hyperprolactinemia 0.5718636087471152
P01563     Tier 1 0.744 13 85.06 0 0       0 0   0 renal cell carcinoma 0.3938654263610389
K7N5M4 B2M   Tier 1 0.72 24 90.94 0 0       1 3 41850110, 40373155, 38904251 0    
Q16878 CDO1 Cysteine dioxygenase type 1 Tier 1 0.72 17 93.62 0 0       0 0   0 adolescent idiopathic scoliosis 0.3105991982786747
Q12918 KLRB1 Killer cell lectin-like receptor subfamily B member 1 Tier 1 0.719 3 81.0 0 0       0 0   0 sensory perception of smell 0.287724180593876
P42262 GRIA2 Glutamate receptor 2 Tier 1 0.715 16 84.94 0 0       1 4 28325839, 19417060, 17929944, 17024188 0 neurodevelopmental disorder with language impairment and behavioral abnormalities 0.8328652004757138
Q99574 SERPINI1 Neuroserpin Tier 1 0.712 3 88.12 0 0       0 0   0 familial encephalopathy with neuroserpin inclusion bodies 0.7162803151916303
A0A583ZB34     Tier 1 0.71 9 84.38 0 0       0 0   0    
P14207 FOLR2 Folate receptor beta Tier 1 0.701 5 89.12 0 0       1 2 28686804 0 neoplasm 0.11545394821329319
P01374 LTA Lymphotoxin-alpha Tier 1 0.7 3 83.44 0 0       1 3 41810142, 30576605 0    
P15248 IL9 Interleukin-9 Tier 1 0.7 5 84.06 0 0       1 1 40972397 0 neurodegenerative disease 0.40148548290272756
Q5Y7D3 HLA-DQB1   Tier 1 0.7 6 85.31 0 0       0 0   0    
P14555 PLA2G2A Phospholipase A2, membrane associated Tier 1 0.7 17 91.0 0 0       0 0   0 familial colorectal cancer 0.3326218692162316
O43570 CA12 Carbonic anhydrase 12 Tier 1 0.695 40 87.81 0 0       0 0   0 isolated hyperchlorhidrosis 0.6794515382695604
Q95460 MR1 Major histocompatibility complex class I-related protein 1 Tier 1 0.693 79 87.5 0 0       1 2 41134135, 20000526 0 Immunodeficiency 0.3336382138166145
Q96QV1 HHIP Hedgehog-interacting protein Tier 1 0.692 11 79.75 0 0       0 0   0 Abnormality of the skeletal system 0.5195282784554633
P04435 TRBV7-9 T cell receptor beta variable 7-9 Tier 1 0.691 2 90.06 0 0       0 0   0 neoplasm 0.11454334012562349
A0A9P1NJI6     Tier 1 0.69 6   0 0       0 0   0    
Q15788 NCOA1 Nuclear receptor coactivator 1 Tier 1 0.69 100 46.72 0 0       0 0   0 neurodegenerative disease 0.48697450901885614
Q9NPF0 CD320 CD320 antigen Tier 1 0.69 6 63.81 0 0       1 1 39493449 0 Methylmalonic aciduria due to transcobalamin receptor defect 0.49918945650121177
Q02083 NAAA N-acylethanolamine-hydrolyzing acid amidase Tier 1 0.69 2 92.25 0 0       0 0   0 abscess 0.2726858643799341
Q9UBH0 IL36RN Interleukin-36 receptor antagonist protein Tier 1 0.687 3 92.44 0 0       0 0   0 psoriasis 14, pustular 0.8155144873787125
A0A0C4DH28 TRGV4 T cell receptor gamma variable 4 Tier 1 0.681 4 84.06 0 0       0 0   0 Townes-Brocks syndrome 0.006652437384324632
Q16651 PRSS8 Prostasin Tier 1 0.68 9 83.75 0 0       0 0   0 Alzheimer disease 0.4223067864061274
P39900 MMP12 Macrophage metalloelastase Tier 1 0.68 86 86.94 0 0       1 8 41861669, 38477735, 38296402, 37015819, 35120890, 34183667, 27530235 0 atopic eczema 0.4795677061208266
U5YJJ6 HLA-A   Tier 1 0.68 3 89.0 0 0       0 0   0    
Q86Z14 KLB Beta-klotho Tier 1 0.676 5 89.38 0 0       1 1 40514411 0 congenital hypogonadotropic hypogonadism 0.462898767992589
Q9GZX9 TWSG1 Twisted gastrulation protein homolog 1 Tier 1 0.67 6 80.38 0 0       1 1 39299474 0 Abruptio Placentae 0.29495361755469174
P62576 nanA Sialidase A Tier 1 0.67 5 81.19 0 0       1 4 37350189, 34976356, 34341854, 32034503 0    
P14867 GABRA1 Gamma-aminobutyric acid receptor subunit alpha-1 Tier 1 0.667 0 81.69 0 0       0 0   0 developmental and epileptic encephalopathy, 19 0.7734302780200346
O15169 AXIN1 Axin-1 Tier 1 0.664 22 61.09 0 0       1 2 28129128 0 hepatocellular carcinoma 0.7864172882686208
P15941 MUC1 Mucin-1 Tier 1 0.66 23 47.41 0 0       1 686 42025056, 41988862, 41954302, 41771296, 41744704, 41744190, 41657320, 41627316, 41621292, 41582516, 41535857, 41471303, 41362016, 41352919, 41346179, 41330302, 41243570, 41205458, 41185018, 41101154, 41047832, 41027169, 40682599, 40665615, 40627939, 40607530, 40590839, 40578633, 40568899, 40556592, 40504676, 40500890, 40499867, 40479828, 40432219, 40422041, 40360093, 40286646, 40274149, 40158809, 40119836, 39978149, 39910821, 39705316, 39679901, 39626346, 39579679, 39566700, 39552005, 39550818, 41997681, 41247195, 40813258, 39454542, 39454415, 39440615, 39421884, 39406784, 39256285, 39243449, 39154820, 39142532, 39136402, 39119745, 39118454, 38923850, 38912896 0 tubulointerstitial kidney disease, autosomal dominant, 2 0.7040398435219726
A0A0U5Q247     Tier 1 0.66 3 85.12 0 0       0 0   0    
Q6IQ20 NAPEPLD N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D Tier 1 0.66 4 87.25 0 0       0 0   0 reticular dystrophy of the retinal pigment epithelium 0.3695798546847018
Q9UHV8 LGALS13 Galactoside-binding soluble lectin 13 Tier 1 0.66 11 97.5 0 0       0 0   0 preeclampsia 0.11027592759014439
Q8IYV9 IZUMO1 Izumo sperm-egg fusion protein 1 Tier 1 0.659 7 81.06 0 0       0 0   0 cholelithiasis 0.18873738346588434
Q92876 KLK6 Kallikrein-6 Tier 1 0.659 21 91.75 0 0       1 2 30114962, 22505517 0 neuroinflammatory disorder 0.1901077464611955
P48552 NRIP1 Nuclear receptor-interacting protein 1 Tier 1 0.657 17 45.91 0 0       0 0   0 neurodegenerative disease 0.5654759320154787
P22894 MMP8 Neutrophil collagenase Tier 1 0.655 25 90.38 0 0       1 4 35821507, 34183667, 33534888, 30197987 0 acne 0.603247809982021
A8MUM7 LGALS16 Galectin-16 Tier 1 0.654 3 94.62 0 0       0 0   0 neurodegenerative disease 0.536067027639694
Q9NZK5 ADA2 Adenosine deaminase 2 Tier 1 0.653 2 95.81 0 0       0 0   0 deficiency of adenosine deaminase 2 0.8291292532404531
A0A592 TCRBV6S1A1N1   Tier 1 0.65 1 88.31 0 0       0 0   0    

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CREATE VIEW v_targets AS
SELECT f.id, n.gene_symbol, n.protein_name, tg.tier, f.priority_score,
 f.pdb_count_total, f.alphafold_mean_pLDDT, f.has_cryoEM,
 f.has_activation_state_pdb_pair, f.activation_state_pdb_active, f.activation_state_pdb_inactive,
 f.drug_count_approved, f.has_known_aptamer, f.aptamer_count_pubmed, ap.aptamer_pmids,
 f.in_cev_map, f.opentargets_top_disease_name, f.opentargets_top_disease_score
FROM v_target_full f
LEFT JOIN target_names n ON n.target_id=f.id
LEFT JOIN targets tg ON tg.id=f.id
LEFT JOIN target_aptamer_pmids ap ON ap.target_id=f.id;