Targets — browse / sort / filter (view)

One row per human protein target with names + key evidence. Click column headers to SORT; use the facets to FILTER (tier, activation pair, known aptamer, EV-Map). UniProt IDs link to the source.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

id
UniProt accession (human). Links to uniprot.org.
gene_symbol
Gene symbol (e.g. ITGB3).
protein_name
Protein name (UniProt).
tier
Tier 1 = PDB-anchored; Tier 1.5 = AlphaFold-confident.
priority_score
Composite prioritisation = 0.30*biology + 0.30*reagent-gap + 0.20*druggability + 0.10*disease + 0.10*novelty. Sub-scores are assigned during LLM-assisted curation — a heuristic ranking, NOT an experimental measurement.
has_activation_state_pdb_pair
1 if a curated ACTIVE/INACTIVE PDB pair exists (only 11 targets).
in_cev_map
1 if in the EV-Map circulating-EV proteome (Rai 2025); 3,422 targets.
has_known_aptamer
1 if aptamer evidence found in PubMed/Aptagen (1,472 targets).
opentargets_top_disease_score
Open Targets association score (0-1).
aptamer_count_pubmed
Number of PubMed hits for this protein AND (aptamer OR SELEX).
aptamer_pmids
The actual PubMed IDs behind the aptamer evidence — click each to read the paper. This is the source of the 'has aptamer' claim.

1,234 rows where has_cryoEM = 0, in_cev_map = 1 and tier = "Tier 1" sorted by priority_score descending

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has_known_aptamer 2

  • 0 830
  • 1 404

has_activation_state_pdb_pair 2

  • 0 1,227
  • 1 7

tier 1

  • Tier 1 · 1,234 ✖

in_cev_map 1

  • 1 · 1,234 ✖

has_cryoEM 1

  • - · 1,234 ✖
id gene_symbol protein_name tier priority_score ▲ pdb_count_total alphafold_mean_pLDDT has_cryoEM has_activation_state_pdb_pair activation_state_pdb_active activation_state_pdb_inactive drug_count_approved has_known_aptamer aptamer_count_pubmed aptamer_pmids in_cev_map opentargets_top_disease_name opentargets_top_disease_score
P13747 HLA-E HLA class I histocompatibility antigen, alpha chain E Tier 1 0.865 34 87.0 0 0       1 1 38473398 1 COVID-19 0.4822929100647597
P01911 HLA-DRB1 HLA class II histocompatibility antigen, DRB1 beta chain Tier 1 0.84 100 88.44 0 0       0 0   1 rheumatoid arthritis 0.40051584219092445
Q15848 ADIPOQ Adiponectin Tier 1 0.806 3 79.88 0 0       1 10 41636061, 38392020, 36508319, 35323639, 34796696, 34117903, 33535822, 31988066, 25105541 1 hearing loss 0.25844907375917336
P35555 FBN1 Fibrillin-1 Tier 1 0.78 11   0 0       0 0   1 Marfan syndrome 0.8969300970597663
P01019 AGT Angiotensinogen Tier 1 0.779 22 86.44 0 0       1 16 35983901, 34936368, 34779902, 34248841, 32838280, 23766021, 17673982, 11419945, 38045440, 34619249, 29844151, 27530235 1 renal tubular dysgenesis 0.7354947364860083
P02671 FGA Fibrinogen alpha chain Tier 1 0.77 40 60.34 0 0       0 0   1 familial dysfibrinogenemia 0.7947496460990987
P03951 F11 Coagulation factor XI Tier 1 0.77 100 86.88 0 0       0 0   1 factor XI deficiency 0.841884208404384
P61769 B2M Beta-2-microglobulin Tier 1 0.77 100 94.06 0 0       1 15 41850110, 40373155, 38904251, 40658810, 35026285, 32631049, 29281176, 28960840, 25100729, 20616783, 19137104, 17878167 1 Immunodeficiency by defective expression of HLA class 1 0.6180318849819645
P05546 SERPIND1 Heparin cofactor 2 Tier 1 0.752 9 79.62 0 0       1 4 20062917, 20053992, 34248840, 31247951 1 heparin cofactor 2 deficiency 0.719744572767547
P05164 MPO Myeloperoxidase Tier 1 0.745 49 89.0 0 0       1 16 41629951, 41316897, 40501769, 38127443, 33534888, 33495506, 37991715, 37277648, 34183667, 34117903, 33869115, 31210423, 30431231 1 myeloperoxidase deficiency 0.7742533340195327
Q9BY67 CADM1 Cell adhesion molecule 1 Tier 1 0.734 2 80.56 0 0       0 0   1 Abnormality of the skeletal system 0.442731358018962
Q99497 PARK7 Parkinson disease protein 7 Tier 1 0.723 88 98.44 0 0       0 0   1 Young adult-onset Parkinsonism 0.7264878745993893
P05187 ALPP Alkaline phosphatase, placental type Tier 1 0.72 8 93.44 0 0       1 7 41329468, 38238732, 37425696, 37047289, 31687420, 25919296, 23467613 1 male reproductive organ cancer 0.16284411775950106
P29622 SERPINA4 Kallistatin Tier 1 0.719 3 86.69 0 0       1 4 38904251, 30297859, 37351609, 28794177 1 optic atrophy 0.28896631154492924
Q96IY4 CPB2 Carboxypeptidase B2 Tier 1 0.709 10 94.12 0 0       1 4 37329944, 36805075, 35861072, 30297859 1 type 2 diabetes mellitus 0.19338213943947646
P01889 HLA-B HLA class I histocompatibility antigen, B alpha chain Tier 1 0.708 100 88.06 0 0       0 0   1 COVID-19 0.48417012135481613
P25311 AZGP1 Zinc-alpha-2-glycoprotein Tier 1 0.701 9 92.88 0 0       1 1 41325160 1 neoplasm 0.10887540652591159
P08473 MME Neprilysin Tier 1 0.699 16 96.19 0 0       0 0   1 Charcot-Marie-Tooth disease axonal type 2T 0.7912653398252156
P00746 CFD Complement factor D Tier 1 0.695 40 91.0 0 0       1 4 38057414, 38071633, 28972568, 25727321 1 recurrent Neisseria infections due to factor D deficiency 0.7726408204424132
Q92187 ST8SIA4 CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase Tier 1 0.69 3 86.44 0 0       0 0   1 systemic lupus erythematosus 0.43832763677821385
O95399 UTS2 Urotensin-2 Tier 1 0.685 2 58.44 0 0       0 0   1 hair color 0.35316475479030335
P01008 SERPINC1 Antithrombin-III Tier 1 0.685 27 84.69 0 0       1 11 32199927, 31881749, 31747245, 25467079, 25186782, 24359968, 23637781, 18316185, 15741074, 10660541, 10457984 1 hereditary antithrombin deficiency 0.8494671886642873
P03950 ANG Angiogenin Tier 1 0.685 56 89.81 0 0       1 99 41948065, 41736700, 41688234, 41686152, 41625383, 41551985, 41550856, 41338305, 41194434, 40839054, 40825091, 40233536, 40046817, 39891801, 39871473, 39727889, 39700796, 39226945, 39078660, 38458987, 38282417, 37683754, 37585601, 37556929, 37527337, 37367006, 37284580, 37185488, 37100807, 36520671, 36315359, 36291000, 36087171, 35731347, 35489276, 35408368, 35290881, 35218097, 35084794, 34987275, 34964948, 34902643, 34617153, 34523638, 34500620, 34474207, 34464491, 34439828, 34350496, 34232998, 27841380, 25461163, 25422408, 22018671, 21774079, 18585145, 18533682, 17260069, 9578572 1 amyotrophic lateral sclerosis 0.7865457274017922
P22303 ACHE Acetylcholinesterase Tier 1 0.685 78 92.94 0 0       1 135 41985393, 41898380, 41654945, 41639270, 41639254, 41565777, 41276911, 41237904, 41230502, 41086326, 41006757, 40855286, 40500390, 40487355, 40452137, 40444021, 40277325, 40262341, 40215752, 40154972, 40128122, 39834132, 39728786, 39689579, 39665919, 39282962, 39102642, 38996565, 38953438, 38949022, 38722683, 38569854, 38559166, 38544485, 38462144, 38410271, 38168820, 38026177, 37905115, 37759795, 37622311, 37506391, 37117194, 36741760, 36551106, 36368824, 36047811, 35842727, 35770801, 35439419, 36971430, 36375221, 36359944, 35479481, 35402070, 35235478, 35057959, 34509014, 33218485, 33096123, 32143069, 31748191, 31170561, 26003847, 25569873, 24756130, 24299064, 12852840 1 Alzheimer disease 0.628678841772617
Q07954 LRP1 Prolow-density lipoprotein receptor-related protein 1 Tier 1 0.682 7 79.19 0 0       1 3 41599761, 38996211, 25855589 1 developmental dysplasia of the hip 0.6197148309275711
Q15485 FCN2 Ficolin-2 Tier 1 0.682 13 85.12 0 0       1 2 27490795 1 hypopituitarism 0.2753784074131916
Q99584 S100A13 Protein S100-A13 Tier 1 0.681 12 80.81 0 0       0 0   1 neurodegenerative disease 0.41302685279153983
Q9HBI1 PARVB Beta-parvin Tier 1 0.68 3 81.75 0 0       0 0   1 thyroiditis 0.28021156500366357
P09958 FURIN Furin Tier 1 0.68 48 84.75 0 0       1 4 36291832, 24808863 1 coronary artery disease 0.5783535503692275
P00918 CA2 Carbonic anhydrase 2 Tier 1 0.68 100 97.38 0 0       1 109 41955789, 41543229, 41513346, 40854266, 40783389, 40744710, 40660917, 40411663, 40380946, 40321028, 39978259, 39928524, 39716707, 39536855, 39515698, 38946763, 38693181, 38462338, 38409486, 37997814, 37726778, 37148800, 37103734, 36792529, 36410157, 36140102, 36107718, 35490167, 35344667, 35211356, 35194086, 35022247, 35006986, 34619285, 34607961, 34440571, 34399193, 34362425, 34166652, 33832411, 33479839, 33410656, 33230701, 33080851, 32991252, 35516485, 32700526, 32493583, 32331372, 32304233 1 Osteopetrosis with renal tubular acidosis 0.7929568656592082
O00602 FCN1 Ficolin-1 Tier 1 0.675 7 84.94 0 0       0 0   1 neurodegenerative disease 0.351581018821974
P09382 LGALS1 Galectin-1 Tier 1 0.675 41 96.5 0 0       1 6 37141264, 33006019, 31778957 1 glaucoma 0.2854257184852107
Q9UK55 SERPINA10 Protein Z-dependent protease inhibitor Tier 1 0.672 4 86.75 0 0       0 0   1 macular degeneration 0.3247169581531489
P25942 CD40 Tumor necrosis factor receptor superfamily member 5 Tier 1 0.67 14 81.19 0 0       1 8 41982466, 37331977, 36203210, 33335251, 26504624, 26231918, 23460531, 12828856 1 hyper-IgM syndrome type 3 0.8038021669520221
P78552 IL13RA1 Interleukin-13 receptor subunit alpha-1 Tier 1 0.67 4 81.56 0 0       0 0   1 type 2 diabetes mellitus 0.48627783096767857
P06703 S100A6 Protein S100-A6 Tier 1 0.67 6 87.19 0 0       0 0   1 neoplasm 0.10449825238323361
P02749 APOH Beta-2-glycoprotein 1 Tier 1 0.67 14 93.12 0 0       0 0   1 atrial fibrillation 0.5456247991985232
P08581 MET Hepatocyte growth factor receptor Tier 1 0.669 100 79.25 0 0       1 149 42012469, 41992303, 41973478, 41873087, 41861669, 41858296, 41848278, 41601428, 41462891, 41391726, 41234744, 41123956, 41084363, 41065179, 41024479, 40954195, 40938088, 40923343, 40840349, 40740738, 40728393, 40640119, 40388621, 40189053, 40116812, 40041032, 39930702, 39853766, 39852082, 39744222, 39735310, 39674868, 39631842, 39586988, 39527480, 39513807, 39355222, 39348183, 39288204, 39087949, 38925633, 38923378, 38876234, 38829176, 38697444, 38515622, 38298092, 38277932, 38230289, 38225704, 30237882, 29416033, 26131766 1 papillary renal cell carcinoma 0.84195976263742
P56817 BACE1 Beta-secretase 1 Tier 1 0.668 100 87.5 0 0       1 9 39241336, 36149663, 35402070, 31513457, 30959405, 29327496, 26473367, 23832586, 16888322 1 metabolic disease 0.42482013576989197
P08311 CTSG Cathepsin G Tier 1 0.667 16 91.38 0 0       1 6 41316897, 40501769, 9062133, 23598134, 19325843 1 tuberculosis 0.37188972877648113
P54762 EPHB1 Ephrin type-B receptor 1 Tier 1 0.665 8 83.62 0 0       0 0   1 medullary thyroid gland carcinoma 0.5204553830376101
Q7L2H7 EIF3M Eukaryotic translation initiation factor 3 subunit M Tier 1 0.66 0 55.28 0 0       0 0   1 Hernia 0.2963310523049043
Q13093 PLA2G7 Platelet-activating factor acetylhydrolase Tier 1 0.66 33 87.81 0 0       1 1 35187107 1 Platelet-activating factor acetylhydrolase deficiency 0.6405981442654826
Q9Y251 HPSE Heparanase Tier 1 0.66 58 94.69 0 0       1 7 41363219, 31252265, 30086306, 28150826, 25295847, 23968994, 22719856 1 Vitiligo 0.3120033501413742
P02461 COL3A1 Collagen alpha-1(III) chain Tier 1 0.656 11 53.25 0 0       1 1 28453726 1 Ehlers-Danlos syndrome, vascular type 0.8608667500207768
P08709 F7 Coagulation factor VII Tier 1 0.655 100 82.12 0 0       1 4 41980687, 32224381, 28496951, 11127866 1 factor VII deficiency 0.8542078994169972
P20701 ITGAL Integrin alpha-L Tier 1 0.655 41 82.62 0 0       0 0   1 psoriasis 0.5899795223699872
P05543 SERPINA7 Thyroxine-binding globulin Tier 1 0.655 9 87.06 0 0       0 0   1 neoplasm 0.09631257418600654
P15907 ST6GAL1 Beta-galactoside alpha-2,6-sialyltransferase 1 Tier 1 0.655 4 88.12 0 0       1 1 41889102 1 COVID-19 0.5471103766359176
P36894 BMPR1A Bone morphogenetic protein receptor type-1A Tier 1 0.653 11 82.62 0 0       1 1 30537181 1 juvenile polyposis syndrome 0.8278395086688584

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CREATE VIEW v_targets AS
SELECT f.id, n.gene_symbol, n.protein_name, tg.tier, f.priority_score,
 f.pdb_count_total, f.alphafold_mean_pLDDT, f.has_cryoEM,
 f.has_activation_state_pdb_pair, f.activation_state_pdb_active, f.activation_state_pdb_inactive,
 f.drug_count_approved, f.has_known_aptamer, f.aptamer_count_pubmed, ap.aptamer_pmids,
 f.in_cev_map, f.opentargets_top_disease_name, f.opentargets_top_disease_score
FROM v_target_full f
LEFT JOIN target_names n ON n.target_id=f.id
LEFT JOIN targets tg ON tg.id=f.id
LEFT JOIN target_aptamer_pmids ap ON ap.target_id=f.id;