Targets — browse / sort / filter (view)

One row per human protein target with names + key evidence. Click column headers to SORT; use the facets to FILTER (tier, activation pair, known aptamer, EV-Map). UniProt IDs link to the source.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

id
UniProt accession (human). Links to uniprot.org.
gene_symbol
Gene symbol (e.g. ITGB3).
protein_name
Protein name (UniProt).
tier
Tier 1 = PDB-anchored; Tier 1.5 = AlphaFold-confident.
priority_score
Composite prioritisation = 0.30*biology + 0.30*reagent-gap + 0.20*druggability + 0.10*disease + 0.10*novelty. Sub-scores are assigned during LLM-assisted curation — a heuristic ranking, NOT an experimental measurement.
has_activation_state_pdb_pair
1 if a curated ACTIVE/INACTIVE PDB pair exists (only 11 targets).
in_cev_map
1 if in the EV-Map circulating-EV proteome (Rai 2025); 3,422 targets.
has_known_aptamer
1 if aptamer evidence found in PubMed/Aptagen (1,472 targets).
opentargets_top_disease_score
Open Targets association score (0-1).
aptamer_count_pubmed
Number of PubMed hits for this protein AND (aptamer OR SELEX).
aptamer_pmids
The actual PubMed IDs behind the aptamer evidence — click each to read the paper. This is the source of the 'has aptamer' claim.

1,298 rows where has_cryoEM = 0, in_cev_map = 1 and tier = "Tier 1.5" sorted by priority_score descending

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Suggested facets: pdb_count_total

has_known_aptamer 2

  • 0 1,112
  • 1 186

has_activation_state_pdb_pair 2

  • 0 1,297
  • 1 1

tier 1

  • Tier 1.5 · 1,298 ✖

in_cev_map 1

  • 1 · 1,298 ✖

has_cryoEM 1

  • - · 1,298 ✖
id gene_symbol protein_name tier priority_score ▲ pdb_count_total alphafold_mean_pLDDT has_cryoEM has_activation_state_pdb_pair activation_state_pdb_active activation_state_pdb_inactive drug_count_approved has_known_aptamer aptamer_count_pubmed aptamer_pmids in_cev_map opentargets_top_disease_name opentargets_top_disease_score
Q9NX14 NDUFB11 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial Tier 1.5 0.86 0 77.56 0 0       0 0   1 Microphthalmia with linear skin defects syndrome 0.7364493324598024
P15260 IFNGR1 Interferon gamma receptor 1 Tier 1.5 0.804 5 66.0 0 0       1 2 33667716 1 disseminated atypical mycobacterial infection 0.5414012388034828
Q9UBT7 CTNNAL1 Alpha-catulin Tier 1.5 0.795 0 84.06 0 0       0 0   1 Abnormality of the skeletal system 0.31316995706583495
P36888 FLT3 Receptor-type tyrosine-protein kinase FLT3 Tier 1.5 0.788 11 75.94 0 0       1 6 41733039, 34364920, 31434881, 30237882, 29299123, 22411871 1 acute myeloid leukemia 0.8313389209288576
P02776 PF4 Platelet factor 4 Tier 1.5 0.77 10 75.06 0 0       1 10 33859620, 32366845, 31967847, 23847186, 23673861, 34248840, 32022468 1 systemic scleroderma 0.11523541376593864
P27037 ACVR2A Activin receptor type-2A Tier 1.5 0.769 5 83.56 0 0       0 0   1 hepatocellular carcinoma 0.4908023126074436
O14958 CASQ2 Calsequestrin-2 Tier 1.5 0.767 4 90.5 0 0       0 0   1 catecholaminergic polymorphic ventricular tachycardia 0.7718998507471558
Q9H3K6 BOLA2 BolA-like protein 2 Tier 1.5 0.765 0 92.69 0 0       0 0   1 hepatocellular carcinoma 0.08093942543094014
Q92956 TNFRSF14 Tumor necrosis factor receptor superfamily member 14 Tier 1.5 0.745 8 79.94 0 0       0 0   1 diffuse large B-cell lymphoma 0.5983171413833771
P98196 ATP11A Phospholipid-transporting ATPase IH Tier 1.5 0.735 0 82.94 0 0       0 0   1 hearing loss, autosomal dominant 84 0.5506821963658654
P16389 KCNA2 Potassium voltage-gated channel subfamily A member 2 Tier 1.5 0.735 0 77.38 0 0       0 0   1 genetic developmental and epileptic encephalopathy 0.7513374591580034
P20702 ITGAX Integrin alpha-X Tier 1.5 0.732 9 88.0 0 0       0 0   1 neurodegenerative disease 0.41708750879240836
P09603     Tier 1.5 0.729 8 57.41 0 0       0 0   1 type 2 diabetes mellitus 0.39219340856589974
Q9P2B2 PTGFRN Prostaglandin F2 receptor negative regulator Tier 1.5 0.728 0 84.12 0 0       0 0   1 type 2 diabetes mellitus 0.48052208463481294
P22732 SLC2A5 Solute carrier family 2, facilitated glucose transporter member 5 Tier 1.5 0.728 0 90.56 0 0       0 0   1 Prolonged QT interval 0.3326218692162316
Q92636 NSMAF Protein FAN Tier 1.5 0.725 0 88.31 0 0       0 0   1 placental retention 0.36802220150078147
P79483 HLA-DRB3 HLA class II histocompatibility antigen, DR beta 3 chain Tier 1.5 0.71 2 88.38 0 0       0 0   1    
P41221 WNT5A Protein Wnt-5a Tier 1.5 0.71 0 87.69 0 0       1 4 40855286, 32693649, 22363130, 18673242 1 Robinow syndrome 0.7220360983378594
O95562 SFT2D2 Vesicle transport protein SFT2B Tier 1.5 0.71 0 78.5 0 0       0 0   1 neurodegenerative disease 0.38598268164814226
P03905 MT-ND4 NADH-ubiquinone oxidoreductase chain 4 Tier 1.5 0.705 0 93.94 0 0       0 0   1 Leber hereditary optic neuropathy 0.7517935125709835
P19021 PAM Peptidyl-glycine alpha-amidating monooxygenase Tier 1.5 0.695 0 71.69 0 0       1 25 41855944, 41500123, 41384307, 41285544, 41222440, 40607956, 39929897, 39472107, 38867016, 38846799, 37977804, 37977780, 37906116, 37127012, 36905684, 35478209, 33911033, 33516855, 32315032, 32307868, 30399413, 30124431, 26406332, 22954359, 14965210 1 type 2 diabetes mellitus 0.5754371880839976
P01615 IGKV2D-28 Immunoglobulin kappa variable 2D-28 Tier 1.5 0.695 0 91.0 0 0       0 0   1 cutaneous Leishmaniasis 0.5868213846274001
Q30154 HLA-DRB5 HLA class II histocompatibility antigen, DR beta 5 chain Tier 1.5 0.694 4 86.75 0 0       0 0   1 seasonal allergic rhinitis 0.19424611770933498
Q9Y678 COPG1 Coatomer subunit gamma-1 Tier 1.5 0.692 1 87.88 0 0       0 0   1 neurodegenerative disease 0.4905625531390244
P36980 CFHR2 Complement factor H-related protein 2 Tier 1.5 0.691 4 90.62 0 0       0 0   1 age-related macular degeneration 0.5100732932209376
P10586 PTPRF Receptor-type tyrosine-protein phosphatase F Tier 1.5 0.69 13 82.0 0 0       1 4 42101929, 39087949, 36594741 1 smoking initiation 0.4641111755355386
Q8IUH8 SPPL2C Signal peptide peptidase-like 2C Tier 1.5 0.69 0 67.06 0 0       0 0   1 osteoarthritis, hip 0.35379836590273994
Q14520 HABP2 Factor VII-activating protease Tier 1.5 0.686 0 77.62 0 0       0 0   1 follicular thyroid carcinoma 0.46213907606907034
O00501 CLDN5 Claudin-5 Tier 1.5 0.685 0 83.75 0 0       1 1 18951306 1 genetic disorder 0.40861362787778505
Q96MP8 KCTD7 BTB/POZ domain-containing protein KCTD7 Tier 1.5 0.685 0 81.12 0 0       0 0   1 progressive myoclonic epilepsy type 3 0.8021556079083692
P14384 CPM Carboxypeptidase M Tier 1.5 0.68 1 90.31 0 0       1 3 38876068, 38060303, 36768220 1 hydronephrosis 0.3163273148871551
O94842 TOX4 TOX high mobility group box family member 4 Tier 1.5 0.68 1 54.72 0 0       0 0   1 neurodegenerative disease 0.43085410155338943
Q96DA2 RAB39B Ras-related protein Rab-39B Tier 1.5 0.678 1 88.38 0 0       0 0   1 early-onset parkinsonism-intellectual disability syndrome 0.7782306319395635
Q9UI42 CPA4 Carboxypeptidase A4 Tier 1.5 0.674 5 93.69 0 0       0 0   1 rheumatoid arthritis 0.19026118958920038
P78357 CNTNAP1 Contactin-associated protein 1 Tier 1.5 0.673 0 81.12 0 0       0 0   1 Hypomyelination neuropathy - arthrogryposis 0.8286745612673082
P09758 TACSTD2 Tumor-associated calcium signal transducer 2 Tier 1.5 0.673 7 82.69 0 0       1 4 41384307, 41241473, 40050871, 39250993 1 gelatinous drop-like corneal dystrophy 0.7293087728162646
P08572 COL4A2 Collagen alpha-2(IV) chain Tier 1.5 0.673 4 47.25 0 0       0 0   1 porencephaly 2 0.7294975109351518
P98066 TNFAIP6 Tumor necrosis factor-inducible gene 6 protein Tier 1.5 0.671 5 81.12 0 0       1 1 39263947 1 type 2 diabetes mellitus 0.30862220597837015
Q4L180 FILIP1L Filamin A-interacting protein 1-like Tier 1.5 0.67 0 67.56 0 0       0 0   1 Umbilical hernia 0.375022308318664
Q9NVH1 DNAJC11 DnaJ homolog subfamily C member 11 Tier 1.5 0.67 0 84.75 0 0       0 0   1 smoking initiation 0.2238015008808092
Q9BXX0 EMILIN2 EMILIN-2 Tier 1.5 0.67 0 65.12 0 0       0 0   1 type 2 diabetes mellitus 0.3471636502626859
Q92997 DVL3 Segment polarity protein dishevelled homolog DVL-3 Tier 1.5 0.67 9 58.91 0 0       0 0   1 autosomal dominant Robinow syndrome 0.7284158836126389
Q14C86 GAPVD1 GTPase-activating protein and VPS9 domain-containing protein 1 Tier 1.5 0.67 0 62.19 0 0       0 0   1 Abnormality of the skeletal system 0.46694942126454214
P22105 TNXB Tenascin-X Tier 1.5 0.669 3 87.81 0 0       0 0   1 Ehlers-Danlos syndrome due to tenascin-X deficiency 0.7916412481554758
P09693 CD3G T-cell surface glycoprotein CD3 gamma chain Tier 1.5 0.667 0 75.25 0 0       0 0   1 combined immunodeficiency due to CD3gamma deficiency 0.7703413570266988
Q15907 RAB11B Ras-related protein Rab-11B Tier 1.5 0.666 3 85.56 0 0       0 0   1 neurodevelopmental disorder with ataxic gait, absent speech, and decreased cortical white matter 0.7587294723766482
Q13049 TRIM32 E3 ubiquitin-protein ligase TRIM32 Tier 1.5 0.665 2 77.88 0 0       0 0   1 autosomal recessive limb-girdle muscular dystrophy type 2H 0.7844213789694698
P48509     Tier 1.5 0.662 0 88.25 0 0       0 0   1 epidermolysis bullosa simplex 7, with nephropathy and deafness 0.7253740723597262
O94985 CLSTN1 Calsyntenin-1 Tier 1.5 0.662 0 77.25 0 0       0 0   1 atrial fibrillation 0.3229417277368247
Q13433 SLC39A6 Zinc transporter ZIP6 Tier 1.5 0.66 0 60.44 0 0       1 1 40132409 1 breast cancer 0.11188167100061543

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CREATE VIEW v_targets AS
SELECT f.id, n.gene_symbol, n.protein_name, tg.tier, f.priority_score,
 f.pdb_count_total, f.alphafold_mean_pLDDT, f.has_cryoEM,
 f.has_activation_state_pdb_pair, f.activation_state_pdb_active, f.activation_state_pdb_inactive,
 f.drug_count_approved, f.has_known_aptamer, f.aptamer_count_pubmed, ap.aptamer_pmids,
 f.in_cev_map, f.opentargets_top_disease_name, f.opentargets_top_disease_score
FROM v_target_full f
LEFT JOIN target_names n ON n.target_id=f.id
LEFT JOIN targets tg ON tg.id=f.id
LEFT JOIN target_aptamer_pmids ap ON ap.target_id=f.id;