Targets — browse / sort / filter (view)

One row per human protein target with names + key evidence. Click column headers to SORT; use the facets to FILTER (tier, activation pair, known aptamer, EV-Map). UniProt IDs link to the source.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

id
UniProt accession (human). Links to uniprot.org.
gene_symbol
Gene symbol (e.g. ITGB3).
protein_name
Protein name (UniProt).
tier
Tier 1 = PDB-anchored; Tier 1.5 = AlphaFold-confident.
priority_score
Composite prioritisation = 0.30*biology + 0.30*reagent-gap + 0.20*druggability + 0.10*disease + 0.10*novelty. Sub-scores are assigned during LLM-assisted curation — a heuristic ranking, NOT an experimental measurement.
has_activation_state_pdb_pair
1 if a curated ACTIVE/INACTIVE PDB pair exists (only 11 targets).
in_cev_map
1 if in the EV-Map circulating-EV proteome (Rai 2025); 3,422 targets.
has_known_aptamer
1 if aptamer evidence found in PubMed/Aptagen (1,472 targets).
opentargets_top_disease_score
Open Targets association score (0-1).
aptamer_count_pubmed
Number of PubMed hits for this protein AND (aptamer OR SELEX).
aptamer_pmids
The actual PubMed IDs behind the aptamer evidence — click each to read the paper. This is the source of the 'has aptamer' claim.

619 rows where has_cryoEM = 1, has_known_aptamer = 0 and in_cev_map = 0 sorted by priority_score descending

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tier 2

in_cev_map 1

has_known_aptamer 1

has_cryoEM 1

has_activation_state_pdb_pair 1

  • 0 619
id gene_symbol protein_name tier priority_score ▲ pdb_count_total alphafold_mean_pLDDT has_cryoEM has_activation_state_pdb_pair activation_state_pdb_active activation_state_pdb_inactive drug_count_approved has_known_aptamer aptamer_count_pubmed aptamer_pmids in_cev_map opentargets_top_disease_name opentargets_top_disease_score
P12263     Tier 1 0.9 7 63.59 1 0       0 0   0    
Q12879 GRIN2A Glutamate receptor ionotropic, NMDA 2A Tier 1 0.88 37 60.84 1 0       0 0   0 Landau-Kleffner syndrome 0.8407159711916629
P35346 SSTR5 Somatostatin receptor type 5 Tier 1.5 0.841 7 81.25 1 0       0 0   0 acromegaly 0.6094707180356006
Q5T848 GPR158 Metabotropic glycine receptor Tier 1 0.839 6 58.03 1 0       0 0   0 diverticular disease 0.4384404783771627
P21439 ABCB4 Phosphatidylcholine translocator ABCB4 Tier 1.5 0.835 4 83.25 1 0       0 0   0 progressive familial intrahepatic cholestasis type 3 0.851728159166962
P0DSE2 TRB M1-specific T cell receptor beta chain Tier 1 0.83 5 90.12 1 0       0 0   0    
O75899 GABBR2 Gamma-aminobutyric acid type B receptor subunit 2 Tier 1.5 0.824 26 77.75 1 0       0 0   0 developmental and epileptic encephalopathy, 59 0.7356789732167734
Q9NS82 SLC7A10 Asc-type amino acid transporter 1 Tier 1 0.803 4 83.38 1 0       0 0   0 asthma 0.5295411410172121
O60895 RAMP2 Receptor activity-modifying protein 2 Tier 1 0.802 10 80.94 1 0       0 0   0 diabetes mellitus 0.4219370007650345
Q04844 CHRNE Acetylcholine receptor subunit epsilon Tier 1.5 0.802 13 80.69 1 0       0 0   0 Congenital myasthenic syndromes 0.8223287249629152
P29275 ADORA2B Adenosine receptor A2b Tier 1.5 0.801 4 88.12 1 0       0 0   0 migraine disorder 0.6060142180667235
Q9H2X9 SLC12A5 Solute carrier family 12 member 5 Tier 1.5 0.8 2 78.44 1 0       0 0   0 genetic developmental and epileptic encephalopathy 0.6993945840545625
P01909 HLA-DQA1 HLA class II histocompatibility antigen, DQ alpha 1 chain Tier 1 0.792 27 87.94 1 0       0 0   0 Pleural Mesothelioma 0.1228600330569846
Q13705 ACVR2B Activin receptor type-2B Tier 1.5 0.791 9 83.31 1 0       0 0   0 Heterotaxia 0.7109733260300651
Q96CS2 HAUS1 HAUS augmin-like complex subunit 1 Tier 1.5 0.79 1 88.62 1 0       0 0   0 device complication 0.27547205131467467
Q5JUK3 KCNT1 Potassium channel subfamily T member 1 Tier 1.5 0.782 6 73.88 1 0       0 0   0 developmental and epileptic encephalopathy, 14 0.8165232785825526
Q13639     Tier 1 0.781 3 80.88 1 0       0 0   0 schizophrenia 0.6060830827022777
P13866 SLC5A1 Sodium/glucose cotransporter 1 Tier 1.5 0.777 4 84.38 1 0       0 0   0 glucose-galactose malabsorption 0.8220991027793896
P30542 ADORA1 Adenosine receptor A1 Tier 1.5 0.777 5 92.44 1 0       0 0   0 asthma 0.7232344154541454
O15393     Tier 1 0.775 31 79.38 1 0       0 0   0 COVID-19 0.6157541390484623
P29460 IL12B Interleukin-12 subunit beta Tier 1 0.769 20 91.12 1 0       0 0   0 psoriasis 0.7914863943708039
P43004 SLC1A2 Excitatory amino acid transporter 2 Tier 1.5 0.768 7 77.75 1 0       0 0   0 developmental and epileptic encephalopathy, 41 0.7772658651722512
O60931 CTNS Cystinosin Tier 1.5 0.764 6 89.44 1 0       0 0   0 nephropathic cystinosis 0.841818398377195
P98073     Tier 1 0.761 14 81.5 1 0       0 0   0 congenital enteropathy due to enteropeptidase deficiency 0.7102613227574134
Q9Y5Y9 SCN10A Sodium channel protein type 10 subunit alpha Tier 1.5 0.761 8 67.31 1 0       0 0   0 atrial fibrillation 0.7126293968222049
O75762 TRPA1 Transient receptor potential cation channel subfamily A member 1 Tier 1 0.76 17 81.94 1 0       0 0   0 familial episodic pain syndrome with predominantly upper body involvement 0.6615353934604322
O15552 FFAR2 Free fatty acid receptor 2 Tier 1.5 0.759 11 88.06 1 0       0 0   0 type 1 diabetes mellitus 0.09182737097469269
P35462 DRD3 D(3) dopamine receptor Tier 1.5 0.757 6 75.38 1 0       0 0   0 schizophrenia 0.6687268941647396
O00591 GABRP Gamma-aminobutyric acid receptor subunit pi Tier 1.5 0.752 2 79.12 1 0       0 0   0 migraine disorder 0.6191855696357259
P0DMS8 ADORA3 Adenosine receptor A3 Tier 1.5 0.751 5 91.31 1 0       0 0   0 migraine disorder 0.6052134617149065
O43614     Tier 1 0.75 11 78.94 1 0       0 0   0 insomnia 0.5988748728311054
P46089 GPR3 G-protein coupled receptor 3 Tier 1.5 0.748 8 81.81 1 0       0 0   0 hypertension 0.18488148594282316
O15245 SLC22A1 Solute carrier family 22 member 1 Tier 1 0.744 16 84.25 1 0       0 0   0 coronary artery disease 0.5384890077265535
Q8N158 GPC2 Glypican-2 Tier 1 0.744 2 79.06 1 0       0 0   0 COVID-19 0.5409211817593593
O43526 KCNQ2 Potassium voltage-gated channel subfamily KQT member 2 Tier 1 0.744 24 58.19 1 0       0 0   0 Benign familial neonatal seizures 0.8423358217314708
P40879 SLC26A3 Chloride anion exchanger Tier 1 0.742 13 85.06 1 0       0 0   0 congenital secretory chloride diarrhea 1 0.8189631913308207
D7RIG0 HLA-DRB1   Tier 1 0.74 10 84.94 1 0       0 0   0    
Q86YT5 SLC13A5 Na(+)/citrate cotransporter Tier 1.5 0.739 4 86.06 1 0       0 0   0 genetic developmental and epileptic encephalopathy 0.6853612674939716
A0A1B0GX56 TRDV1 T cell receptor delta variable 1 Tier 1 0.737 7 90.69 1 0       0 0   0 colorectal carcinoma 0.07391597093694036
Q14028 CNGB1 Cyclic nucleotide-gated channel beta-1 Tier 1 0.734 11 57.66 1 0       0 0   0 retinitis pigmentosa 0.7931901344765326
P41145 OPRK1 Kappa-type opioid receptor Tier 1 0.725 28 79.5 1 0       0 0   0 alcohol dependence 0.6106562988740131
Q9H741 SPRING1 SREBP regulating gene protein Tier 1.5 0.725 2 81.31 1 0       0 0   0 Anxiety 0.35244791107935663
P48764 SLC9A3 Sodium/hydrogen exchanger 3 Tier 1.5 0.725 1 65.94 1 0       0 0   0 congenital sodium diarrhea 0.6503153836708786
P23416 GLRA2 Glycine receptor subunit alpha-2 Tier 1 0.723 13 83.81 1 0       0 0   0 intellectual developmental disorder, X-linked, syndromic, Pilorge type 0.7805605973560554
P41968 MC3R Melanocortin receptor 3 Tier 1.5 0.723 6 83.88 1 0       0 0   0 alcohol drinking 0.3298167673588826
P29033 GJB2 Gap junction beta-2 protein Tier 1 0.72 24 86.19 1 0       0 0   0 palmoplantar keratoderma-deafness syndrome 0.8149616697051898
B7Z8K6 TRDC T cell receptor delta constant Tier 1 0.72 12 81.38 1 0       0 0   0    
Q9NZD1 GPRC5D G-protein coupled receptor family C group 5 member D Tier 1.5 0.716 2 76.06 1 0       0 0   0 multiple myeloma 0.5555243624684951
A0A0B4J271 TRAV12-3 T cell receptor alpha variable 12-3 Tier 1 0.715 12 92.56 1 0       0 0   0 ulcerative colitis 0.003139210371371825
Q695T7 SLC6A19 Sodium-dependent neutral amino acid transporter B(0)AT1 Tier 1 0.715 19 90.0 1 0       0 0   0 Hartnup disease 0.8464240093600148

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CREATE VIEW v_targets AS
SELECT f.id, n.gene_symbol, n.protein_name, tg.tier, f.priority_score,
 f.pdb_count_total, f.alphafold_mean_pLDDT, f.has_cryoEM,
 f.has_activation_state_pdb_pair, f.activation_state_pdb_active, f.activation_state_pdb_inactive,
 f.drug_count_approved, f.has_known_aptamer, f.aptamer_count_pubmed, ap.aptamer_pmids,
 f.in_cev_map, f.opentargets_top_disease_name, f.opentargets_top_disease_score
FROM v_target_full f
LEFT JOIN target_names n ON n.target_id=f.id
LEFT JOIN targets tg ON tg.id=f.id
LEFT JOIN target_aptamer_pmids ap ON ap.target_id=f.id;