Targets — browse / sort / filter (view)

One row per human protein target with names + key evidence. Click column headers to SORT; use the facets to FILTER (tier, activation pair, known aptamer, EV-Map). UniProt IDs link to the source.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

id
UniProt accession (human). Links to uniprot.org.
gene_symbol
Gene symbol (e.g. ITGB3).
protein_name
Protein name (UniProt).
tier
Tier 1 = PDB-anchored; Tier 1.5 = AlphaFold-confident.
priority_score
Composite prioritisation = 0.30*biology + 0.30*reagent-gap + 0.20*druggability + 0.10*disease + 0.10*novelty. Sub-scores are assigned during LLM-assisted curation — a heuristic ranking, NOT an experimental measurement.
has_activation_state_pdb_pair
1 if a curated ACTIVE/INACTIVE PDB pair exists (only 11 targets).
in_cev_map
1 if in the EV-Map circulating-EV proteome (Rai 2025); 3,422 targets.
has_known_aptamer
1 if aptamer evidence found in PubMed/Aptagen (1,472 targets).
opentargets_top_disease_score
Open Targets association score (0-1).
aptamer_count_pubmed
Number of PubMed hits for this protein AND (aptamer OR SELEX).
aptamer_pmids
The actual PubMed IDs behind the aptamer evidence — click each to read the paper. This is the source of the 'has aptamer' claim.

636 rows where has_cryoEM = 1, has_known_aptamer = 0 and in_cev_map = 1 sorted by priority_score descending

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tier 3

has_activation_state_pdb_pair 2

  • 0 635
  • 1 1

in_cev_map 1

has_known_aptamer 1

has_cryoEM 1

id gene_symbol protein_name tier priority_score ▲ pdb_count_total alphafold_mean_pLDDT has_cryoEM has_activation_state_pdb_pair activation_state_pdb_active activation_state_pdb_inactive drug_count_approved has_known_aptamer aptamer_count_pubmed aptamer_pmids in_cev_map opentargets_top_disease_name opentargets_top_disease_score
Q02094 RHAG Ammonium transporter Rh type A Tier 1.5 0.841 8 95.62 1 0       0 0   1 Rh deficiency syndrome 0.764209214915708
Q14392 LRRC32 Transforming growth factor beta activator LRRC32 Tier 1.5 0.838 6 86.06 1 0       0 0   1 cleft palate, proliferative retinopathy, and developmental delay 0.5770707112957068
P12532 CKMT1A Creatine kinase U-type, mitochondrial Tier 1.5 0.83 9 89.31 1 0       0 0   1 neurodegenerative disease 0.5385822922582763
P54709 ATP1B3 Sodium/potassium-transporting ATPase subunit beta-3 Tier 1.5 0.81 7 89.69 1 0       0 0   1 congestive heart failure 0.5999952111132625
P43005 SLC1A1 Excitatory amino acid transporter 3 Tier 1 0.805 22 80.12 1 0       0 0   1 dicarboxylic aminoaciduria 0.6273449709512636
P00488 F13A1 Coagulation factor XIII A chain Tier 1 0.799 15 90.88 1 0       0 0   1 Factor XIII subunit A deficiency 0.7939842013132387
P06731 CEACAM5 Cell adhesion molecule CEACAM5 Tier 1 0.795 6 87.12 1 0       0 0   1 neurodegenerative disease 0.45156128674958135
P02747 C1QC Complement C1q subcomponent subunit C Tier 1 0.762 11 80.56 1 0       0 0   1 C1Q deficiency 0.6233532074390745
O60568 PLOD3 Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 Tier 1.5 0.762 18 91.38 1 0       0 0   1 bone fragility with contractures, arterial rupture, and deafness 0.7159150369336311
Q02817 MUC2 Mucin-2 Tier 1 0.76 12   1 0       0 0   1    
P07360     Tier 1 0.755 15 89.75 1 0       0 0   1 complement deficiency 0.3695798546847018
P41440 SLC19A1 Reduced folate transporter Tier 1.5 0.755 19 72.06 1 0       0 0   1 Knobloch syndrome 0.5526223217595396
P55899 FCGRT IgG receptor FcRn large subunit p51 Tier 1 0.752 31 85.0 1 0       0 0   1 Myasthenia gravis 0.5932721106551206
P26022 PTX3 Pentraxin-related protein PTX3 Tier 1.5 0.75 9 76.75 1 0       0 0   1 polycystic ovary syndrome 0.12287624125782433
Q9Y653 ADGRG1 Adhesion G-protein coupled receptor G1 Tier 1.5 0.743 1 77.88 1 0       0 0   1 bilateral frontoparietal polymicrogyria 0.8322298896713178
P11215 ITGAM Integrin alpha-M Tier 1 0.72 30 86.25 1 0       0 0   1 systemic lupus erythematosus 0.30502849242596436
P07942 LAMB1 Laminin subunit beta-1 Tier 1.5 0.72 3 76.69 1 0       0 0   1 cobblestone lissencephaly without muscular or ocular involvement 0.8016665947624902
Q9NR82 KCNQ5 Potassium voltage-gated channel subfamily KQT member 5 Tier 1.5 0.711 5 56.41 1 0       0 0   1 intellectual disability, autosomal dominant 46 0.7086662845211597
Q9NV96 TMEM30A Cell cycle control protein 50A Tier 1 0.71 33 89.5 1 0       0 0   1 atrial fibrillation 0.31177132249681394
O60486 PLXNC1 Plexin-C1 Tier 1 0.703 4 79.06 1 0       0 0   1 asthma 0.532656225351722
P14770 GP9 Platelet glycoprotein IX Tier 1.5 0.702 2 84.69 1 0       0 0   1 Bernard-Soulier syndrome 0.8233582238860002
P01825 IGHV4-59 Immunoglobulin heavy variable 4-59 Tier 1.5 0.69 3 91.56 1 0       0 0   1 cutaneous Leishmaniasis 0.5868213846274001
Q8NBJ9     Tier 1 0.688 7 80.25 1 0       0 0   1 hypothyroidism 0.32686531914177924
Q6NT16 SLC18B1 MFS-type transporter SLC18B1 Tier 1.5 0.688 4 84.62 1 0       0 0   1 Parkinson disease 0.276931649354752
Q99250 SCN2A Sodium channel protein type 2 subunit alpha Tier 1.5 0.685 5 68.81 1 0       0 0   1 developmental and epileptic encephalopathy, 11 0.8388748085806758
P63092 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Tier 1 0.683 100 91.31 1 0       0 0   1 pseudohypoparathyroidism type 1A 0.826829760867455
Q14213     Tier 1 0.683 4 87.62 1 0       0 0   1 neurodegenerative disease 0.42776938116451996
Q15582 TGFBI Transforming growth factor-beta-induced protein ig-h3 Tier 1.5 0.682 10 90.25 1 0       0 0   1 lattice corneal dystrophy type I 0.8242841141270143
Q9UNN8 PROCR Endothelial protein C receptor Tier 1 0.68 13 86.44 1 0       0 0   1 venous thromboembolism 0.5497662282245215
O75935 DCTN3 Dynactin subunit 3 Tier 1.5 0.68 1 88.38 1 0       0 0   1 viral disease 0.03700998752471888
Q8TD43 TRPM4 Transient receptor potential cation channel subfamily M member 4 Tier 1.5 0.68 25 77.44 1 0       0 0   1 Familial progressive cardiac conduction defect 0.7868180621357534
P05023 ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 Tier 1.5 0.679 10 88.69 1 0       0 0   1 Charcot-Marie-tooth disease, axonal, type 2DD 0.7868851290226483
Q92536 SLC7A6 Y+L amino acid transporter 2 Tier 1.5 0.678 2 83.19 1 0       0 0   1 Abnormality of the skeletal system 0.48544421359843914
P36021 SLC16A2 Monocarboxylate transporter 8 Tier 1.5 0.675 7 79.56 1 0       0 0   1 Allan-Herndon-Dudley syndrome 0.8533069932022032
P18564 ITGB6 Integrin beta-6 Tier 1.5 0.675 14 82.88 1 0       0 0   1 Hypoplastic amelogenesis imperfecta 0.6045342804405103
P32241 VIPR1 Vasoactive intestinal polypeptide receptor 1 Tier 1.5 0.667 17 76.0 1 0       0 0   1 diverticular disease 0.2747596866638145
O95563 MPC2 Mitochondrial pyruvate carrier 2 Tier 1.5 0.665 17 89.44 1 0       0 0   1 mitochondrial pyruvate carrier deficiency 0.18534429712437792
O15554 KCNN4 Intermediate conductance calcium-activated potassium channel protein 4 Tier 1.5 0.661 17 84.19 1 0       0 0   1 dehydrated hereditary stomatocytosis 0.7145864899974032
Q14344 GNA13 Guanine nucleotide-binding protein subunit alpha-13 Tier 1 0.66 17 91.44 1 0       0 0   1 lymphoma 0.37253457492562664
Q14524 SCN5A Sodium channel protein type 5 subunit alpha Tier 1.5 0.654 16 67.25 1 0       0 0   1 long QT syndrome 3 0.8448298602976083
P13637 ATP1A3 Sodium/potassium-transporting ATPase subunit alpha-3 Tier 1.5 0.654 5 88.81 1 0       0 0   1 alternating hemiplegia of childhood 2 0.842328126568451
Q5JWF2 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas Tier 1 0.653 9 56.72 1 0       0 0   1 pseudohypoparathyroidism type 1A 0.826829760867455
Q13936 CACNA1C Voltage-dependent L-type calcium channel subunit alpha-1C Tier 1 0.65 33 61.94 1 0       0 0   1 Timothy syndrome 0.8227725490420764
O60449 LY75 Lymphocyte antigen 75 Tier 1.5 0.65 4 75.62 1 0       0 0   1 Abruptio Placentae 0.31953367678705413
Q15027 ACAP1 Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 Tier 1.5 0.649 7 84.38 1 0       0 0   1 hypothyroidism 0.4891091360736571
O00468 AGRN Agrin Tier 1.5 0.649 1 68.81 1 0       0 0   1 congenital myasthenic syndrome 8 0.7912009864338403
O00478 BTN3A3 Butyrophilin subfamily 3 member A3 Tier 1.5 0.648 9 82.81 1 0       0 0   1 neoplasm 0.07870866954589865
Q8TEM1 NUP210 Nuclear pore membrane glycoprotein 210 Tier 1.5 0.644 2 79.56 1 0       0 0   1 HIV infection 0.5409211817593593
Q9Y4R8 TELO2 Telomere length regulation protein TEL2 homolog Tier 1.5 0.64 3 83.88 1 0       0 0   1 TELO2-related intellectual disability-neurodevelopmental disorder 0.7971337980726797
O60443 GSDME Gasdermin-E Tier 1.5 0.638 2 77.44 1 0       0 0   1 autosomal dominant nonsyndromic hearing loss 0.6288670542083885

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CREATE VIEW v_targets AS
SELECT f.id, n.gene_symbol, n.protein_name, tg.tier, f.priority_score,
 f.pdb_count_total, f.alphafold_mean_pLDDT, f.has_cryoEM,
 f.has_activation_state_pdb_pair, f.activation_state_pdb_active, f.activation_state_pdb_inactive,
 f.drug_count_approved, f.has_known_aptamer, f.aptamer_count_pubmed, ap.aptamer_pmids,
 f.in_cev_map, f.opentargets_top_disease_name, f.opentargets_top_disease_score
FROM v_target_full f
LEFT JOIN target_names n ON n.target_id=f.id
LEFT JOIN targets tg ON tg.id=f.id
LEFT JOIN target_aptamer_pmids ap ON ap.target_id=f.id;