Targets — browse / sort / filter (view)

One row per human protein target with names + key evidence. Click column headers to SORT; use the facets to FILTER (tier, activation pair, known aptamer, EV-Map). UniProt IDs link to the source.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

id
UniProt accession (human). Links to uniprot.org.
gene_symbol
Gene symbol (e.g. ITGB3).
protein_name
Protein name (UniProt).
tier
Tier 1 = PDB-anchored; Tier 1.5 = AlphaFold-confident.
priority_score
Composite prioritisation = 0.30*biology + 0.30*reagent-gap + 0.20*druggability + 0.10*disease + 0.10*novelty. Sub-scores are assigned during LLM-assisted curation — a heuristic ranking, NOT an experimental measurement.
has_activation_state_pdb_pair
1 if a curated ACTIVE/INACTIVE PDB pair exists (only 11 targets).
in_cev_map
1 if in the EV-Map circulating-EV proteome (Rai 2025); 3,422 targets.
has_known_aptamer
1 if aptamer evidence found in PubMed/Aptagen (1,472 targets).
opentargets_top_disease_score
Open Targets association score (0-1).
aptamer_count_pubmed
Number of PubMed hits for this protein AND (aptamer OR SELEX).
aptamer_pmids
The actual PubMed IDs behind the aptamer evidence — click each to read the paper. This is the source of the 'has aptamer' claim.

845 rows where has_cryoEM = 1, has_known_aptamer = 0 and tier = "Tier 1" sorted by priority_score descending

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in_cev_map 2

  • 1 448
  • 0 397

tier 1

  • Tier 1 · 845 ✖

has_known_aptamer 1

has_cryoEM 1

has_activation_state_pdb_pair 1

  • 0 845
id gene_symbol protein_name tier priority_score ▲ pdb_count_total alphafold_mean_pLDDT has_cryoEM has_activation_state_pdb_pair activation_state_pdb_active activation_state_pdb_inactive drug_count_approved has_known_aptamer aptamer_count_pubmed aptamer_pmids in_cev_map opentargets_top_disease_name opentargets_top_disease_score
P12263     Tier 1 0.9 7 63.59 1 0       0 0   0    
Q12879 GRIN2A Glutamate receptor ionotropic, NMDA 2A Tier 1 0.88 37 60.84 1 0       0 0   0 Landau-Kleffner syndrome 0.8407159711916629
Q5T848 GPR158 Metabotropic glycine receptor Tier 1 0.839 6 58.03 1 0       0 0   0 diverticular disease 0.4384404783771627
P0DSE2 TRB M1-specific T cell receptor beta chain Tier 1 0.83 5 90.12 1 0       0 0   0    
P43005 SLC1A1 Excitatory amino acid transporter 3 Tier 1 0.805 22 80.12 1 0       0 0   1 dicarboxylic aminoaciduria 0.6273449709512636
Q9NS82 SLC7A10 Asc-type amino acid transporter 1 Tier 1 0.803 4 83.38 1 0       0 0   0 asthma 0.5295411410172121
O60895 RAMP2 Receptor activity-modifying protein 2 Tier 1 0.802 10 80.94 1 0       0 0   0 diabetes mellitus 0.4219370007650345
P00488 F13A1 Coagulation factor XIII A chain Tier 1 0.799 15 90.88 1 0       0 0   1 Factor XIII subunit A deficiency 0.7939842013132387
P06731 CEACAM5 Cell adhesion molecule CEACAM5 Tier 1 0.795 6 87.12 1 0       0 0   1 neurodegenerative disease 0.45156128674958135
P01909 HLA-DQA1 HLA class II histocompatibility antigen, DQ alpha 1 chain Tier 1 0.792 27 87.94 1 0       0 0   0 Pleural Mesothelioma 0.1228600330569846
Q13639     Tier 1 0.781 3 80.88 1 0       0 0   0 schizophrenia 0.6060830827022777
O15393     Tier 1 0.775 31 79.38 1 0       0 0   0 COVID-19 0.6157541390484623
P29460 IL12B Interleukin-12 subunit beta Tier 1 0.769 20 91.12 1 0       0 0   0 psoriasis 0.7914863943708039
P02747 C1QC Complement C1q subcomponent subunit C Tier 1 0.762 11 80.56 1 0       0 0   1 C1Q deficiency 0.6233532074390745
P98073     Tier 1 0.761 14 81.5 1 0       0 0   0 congenital enteropathy due to enteropeptidase deficiency 0.7102613227574134
O75762 TRPA1 Transient receptor potential cation channel subfamily A member 1 Tier 1 0.76 17 81.94 1 0       0 0   0 familial episodic pain syndrome with predominantly upper body involvement 0.6615353934604322
Q02817 MUC2 Mucin-2 Tier 1 0.76 12   1 0       0 0   1    
P07360     Tier 1 0.755 15 89.75 1 0       0 0   1 complement deficiency 0.3695798546847018
P55899 FCGRT IgG receptor FcRn large subunit p51 Tier 1 0.752 31 85.0 1 0       0 0   1 Myasthenia gravis 0.5932721106551206
O43614     Tier 1 0.75 11 78.94 1 0       0 0   0 insomnia 0.5988748728311054
O15245 SLC22A1 Solute carrier family 22 member 1 Tier 1 0.744 16 84.25 1 0       0 0   0 coronary artery disease 0.5384890077265535
Q8N158 GPC2 Glypican-2 Tier 1 0.744 2 79.06 1 0       0 0   0 COVID-19 0.5409211817593593
O43526 KCNQ2 Potassium voltage-gated channel subfamily KQT member 2 Tier 1 0.744 24 58.19 1 0       0 0   0 Benign familial neonatal seizures 0.8423358217314708
P40879 SLC26A3 Chloride anion exchanger Tier 1 0.742 13 85.06 1 0       0 0   0 congenital secretory chloride diarrhea 1 0.8189631913308207
D7RIG0 HLA-DRB1   Tier 1 0.74 10 84.94 1 0       0 0   0    
A0A1B0GX56 TRDV1 T cell receptor delta variable 1 Tier 1 0.737 7 90.69 1 0       0 0   0 colorectal carcinoma 0.07391597093694036
Q14028 CNGB1 Cyclic nucleotide-gated channel beta-1 Tier 1 0.734 11 57.66 1 0       0 0   0 retinitis pigmentosa 0.7931901344765326
P41145 OPRK1 Kappa-type opioid receptor Tier 1 0.725 28 79.5 1 0       0 0   0 alcohol dependence 0.6106562988740131
P23416 GLRA2 Glycine receptor subunit alpha-2 Tier 1 0.723 13 83.81 1 0       0 0   0 intellectual developmental disorder, X-linked, syndromic, Pilorge type 0.7805605973560554
P11215 ITGAM Integrin alpha-M Tier 1 0.72 30 86.25 1 0       0 0   1 systemic lupus erythematosus 0.30502849242596436
P29033 GJB2 Gap junction beta-2 protein Tier 1 0.72 24 86.19 1 0       0 0   0 palmoplantar keratoderma-deafness syndrome 0.8149616697051898
B7Z8K6 TRDC T cell receptor delta constant Tier 1 0.72 12 81.38 1 0       0 0   0    
A0A0B4J271 TRAV12-3 T cell receptor alpha variable 12-3 Tier 1 0.715 12 92.56 1 0       0 0   0 ulcerative colitis 0.003139210371371825
Q695T7 SLC6A19 Sodium-dependent neutral amino acid transporter B(0)AT1 Tier 1 0.715 19 90.0 1 0       0 0   0 Hartnup disease 0.8464240093600148
Q9NV96 TMEM30A Cell cycle control protein 50A Tier 1 0.71 33 89.5 1 0       0 0   1 atrial fibrillation 0.31177132249681394
P49019 HCAR3 Hydroxycarboxylic acid receptor 3 Tier 1 0.709 11 79.19 1 0       0 0   0 Oral ulcer 0.3943093179045574
O15342 ATP6V0E1 V-type proton ATPase subunit e 1 Tier 1 0.708 9 92.88 1 0       0 0   0 multiple myeloma 0.18220286553988743
Q9BXJ8 TMEM120A Transmembrane protein 120A Tier 1 0.706 5 89.25 1 0       0 0   0 congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency 0.1609725589293368
O60486 PLXNC1 Plexin-C1 Tier 1 0.703 4 79.06 1 0       0 0   1 asthma 0.532656225351722
P22888 LHCGR Lutropin-choriogonadotropic hormone receptor Tier 1 0.698 4 80.12 1 0       0 0   0 Leydig cell hypoplasia, type 1 0.783461117057047
Q07699 SCN1B Sodium channel regulatory subunit beta-1 Tier 1 0.695 36 87.06 1 0       0 0   0 Generalized epilepsy with febrile seizures-plus 0.7638796221342504
P30989 NTSR1 Neurotensin receptor type 1 Tier 1 0.695 24 79.62 1 0       0 0   0 Cough 0.31206841983343936
Q8NBJ9     Tier 1 0.688 7 80.25 1 0       0 0   1 hypothyroidism 0.32686531914177924
P63092 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Tier 1 0.683 100 91.31 1 0       0 0   1 pseudohypoparathyroidism type 1A 0.826829760867455
Q14213     Tier 1 0.683 4 87.62 1 0       0 0   1 neurodegenerative disease 0.42776938116451996
Q96RJ0 TAAR1 Trace amine-associated receptor 1 Tier 1 0.68 17 90.06 1 0       0 0   0 schizophrenia 0.41827765417829765
Q9UNN8 PROCR Endothelial protein C receptor Tier 1 0.68 13 86.44 1 0       0 0   1 venous thromboembolism 0.5497662282245215
Q14973 SLC10A1 Hepatic sodium/bile acid cotransporter Tier 1 0.679 11 83.5 1 0       0 0   0 hypercholanemia, familial, 2 0.6937781800382379
O15399 GRIN2D Glutamate receptor ionotropic, NMDA 2D Tier 1 0.675 13 63.22 1 0       0 0   0 developmental and epileptic encephalopathy, 46 0.7529662497608808
Q8TDV5 GPR119 Glucose-dependent insulinotropic receptor Tier 1 0.67 9 86.75 1 0       0 0   0 neurodegenerative disease 0.2992783744181862

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CREATE VIEW v_targets AS
SELECT f.id, n.gene_symbol, n.protein_name, tg.tier, f.priority_score,
 f.pdb_count_total, f.alphafold_mean_pLDDT, f.has_cryoEM,
 f.has_activation_state_pdb_pair, f.activation_state_pdb_active, f.activation_state_pdb_inactive,
 f.drug_count_approved, f.has_known_aptamer, f.aptamer_count_pubmed, ap.aptamer_pmids,
 f.in_cev_map, f.opentargets_top_disease_name, f.opentargets_top_disease_score
FROM v_target_full f
LEFT JOIN target_names n ON n.target_id=f.id
LEFT JOIN targets tg ON tg.id=f.id
LEFT JOIN target_aptamer_pmids ap ON ap.target_id=f.id;