Targets — browse / sort / filter (view)

One row per human protein target with names + key evidence. Click column headers to SORT; use the facets to FILTER (tier, activation pair, known aptamer, EV-Map). UniProt IDs link to the source.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

id
UniProt accession (human). Links to uniprot.org.
gene_symbol
Gene symbol (e.g. ITGB3).
protein_name
Protein name (UniProt).
tier
Tier 1 = PDB-anchored; Tier 1.5 = AlphaFold-confident.
priority_score
Composite prioritisation = 0.30*biology + 0.30*reagent-gap + 0.20*druggability + 0.10*disease + 0.10*novelty. Sub-scores are assigned during LLM-assisted curation — a heuristic ranking, NOT an experimental measurement.
has_activation_state_pdb_pair
1 if a curated ACTIVE/INACTIVE PDB pair exists (only 11 targets).
in_cev_map
1 if in the EV-Map circulating-EV proteome (Rai 2025); 3,422 targets.
has_known_aptamer
1 if aptamer evidence found in PubMed/Aptagen (1,472 targets).
opentargets_top_disease_score
Open Targets association score (0-1).
aptamer_count_pubmed
Number of PubMed hits for this protein AND (aptamer OR SELEX).
aptamer_pmids
The actual PubMed IDs behind the aptamer evidence — click each to read the paper. This is the source of the 'has aptamer' claim.

409 rows where has_cryoEM = 1, has_known_aptamer = 0 and tier = "Tier 1.5" sorted by priority_score descending

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Suggested facets: pdb_count_total

in_cev_map 2

  • 0 222
  • 1 187

tier 1

  • Tier 1.5 · 409 ✖

has_known_aptamer 1

has_cryoEM 1

has_activation_state_pdb_pair 1

  • 0 409
id gene_symbol protein_name tier priority_score ▲ pdb_count_total alphafold_mean_pLDDT has_cryoEM has_activation_state_pdb_pair activation_state_pdb_active activation_state_pdb_inactive drug_count_approved has_known_aptamer aptamer_count_pubmed aptamer_pmids in_cev_map opentargets_top_disease_name opentargets_top_disease_score
Q02094 RHAG Ammonium transporter Rh type A Tier 1.5 0.841 8 95.62 1 0       0 0   1 Rh deficiency syndrome 0.764209214915708
P35346 SSTR5 Somatostatin receptor type 5 Tier 1.5 0.841 7 81.25 1 0       0 0   0 acromegaly 0.6094707180356006
Q14392 LRRC32 Transforming growth factor beta activator LRRC32 Tier 1.5 0.838 6 86.06 1 0       0 0   1 cleft palate, proliferative retinopathy, and developmental delay 0.5770707112957068
P21439 ABCB4 Phosphatidylcholine translocator ABCB4 Tier 1.5 0.835 4 83.25 1 0       0 0   0 progressive familial intrahepatic cholestasis type 3 0.851728159166962
P12532 CKMT1A Creatine kinase U-type, mitochondrial Tier 1.5 0.83 9 89.31 1 0       0 0   1 neurodegenerative disease 0.5385822922582763
O75899 GABBR2 Gamma-aminobutyric acid type B receptor subunit 2 Tier 1.5 0.824 26 77.75 1 0       0 0   0 developmental and epileptic encephalopathy, 59 0.7356789732167734
P54709 ATP1B3 Sodium/potassium-transporting ATPase subunit beta-3 Tier 1.5 0.81 7 89.69 1 0       0 0   1 congestive heart failure 0.5999952111132625
Q04844 CHRNE Acetylcholine receptor subunit epsilon Tier 1.5 0.802 13 80.69 1 0       0 0   0 Congenital myasthenic syndromes 0.8223287249629152
P29275 ADORA2B Adenosine receptor A2b Tier 1.5 0.801 4 88.12 1 0       0 0   0 migraine disorder 0.6060142180667235
Q9H2X9 SLC12A5 Solute carrier family 12 member 5 Tier 1.5 0.8 2 78.44 1 0       0 0   0 genetic developmental and epileptic encephalopathy 0.6993945840545625
Q13705 ACVR2B Activin receptor type-2B Tier 1.5 0.791 9 83.31 1 0       0 0   0 Heterotaxia 0.7109733260300651
Q96CS2 HAUS1 HAUS augmin-like complex subunit 1 Tier 1.5 0.79 1 88.62 1 0       0 0   0 device complication 0.27547205131467467
Q5JUK3 KCNT1 Potassium channel subfamily T member 1 Tier 1.5 0.782 6 73.88 1 0       0 0   0 developmental and epileptic encephalopathy, 14 0.8165232785825526
P13866 SLC5A1 Sodium/glucose cotransporter 1 Tier 1.5 0.777 4 84.38 1 0       0 0   0 glucose-galactose malabsorption 0.8220991027793896
P30542 ADORA1 Adenosine receptor A1 Tier 1.5 0.777 5 92.44 1 0       0 0   0 asthma 0.7232344154541454
P43004 SLC1A2 Excitatory amino acid transporter 2 Tier 1.5 0.768 7 77.75 1 0       0 0   0 developmental and epileptic encephalopathy, 41 0.7772658651722512
O60931 CTNS Cystinosin Tier 1.5 0.764 6 89.44 1 0       0 0   0 nephropathic cystinosis 0.841818398377195
O60568 PLOD3 Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 Tier 1.5 0.762 18 91.38 1 0       0 0   1 bone fragility with contractures, arterial rupture, and deafness 0.7159150369336311
Q9Y5Y9 SCN10A Sodium channel protein type 10 subunit alpha Tier 1.5 0.761 8 67.31 1 0       0 0   0 atrial fibrillation 0.7126293968222049
O15552 FFAR2 Free fatty acid receptor 2 Tier 1.5 0.759 11 88.06 1 0       0 0   0 type 1 diabetes mellitus 0.09182737097469269
P35462 DRD3 D(3) dopamine receptor Tier 1.5 0.757 6 75.38 1 0       0 0   0 schizophrenia 0.6687268941647396
P41440 SLC19A1 Reduced folate transporter Tier 1.5 0.755 19 72.06 1 0       0 0   1 Knobloch syndrome 0.5526223217595396
O00591 GABRP Gamma-aminobutyric acid receptor subunit pi Tier 1.5 0.752 2 79.12 1 0       0 0   0 migraine disorder 0.6191855696357259
P0DMS8 ADORA3 Adenosine receptor A3 Tier 1.5 0.751 5 91.31 1 0       0 0   0 migraine disorder 0.6052134617149065
P26022 PTX3 Pentraxin-related protein PTX3 Tier 1.5 0.75 9 76.75 1 0       0 0   1 polycystic ovary syndrome 0.12287624125782433
P46089 GPR3 G-protein coupled receptor 3 Tier 1.5 0.748 8 81.81 1 0       0 0   0 hypertension 0.18488148594282316
Q9Y653 ADGRG1 Adhesion G-protein coupled receptor G1 Tier 1.5 0.743 1 77.88 1 0       0 0   1 bilateral frontoparietal polymicrogyria 0.8322298896713178
Q86YT5 SLC13A5 Na(+)/citrate cotransporter Tier 1.5 0.739 4 86.06 1 0       0 0   0 genetic developmental and epileptic encephalopathy 0.6853612674939716
Q9H741 SPRING1 SREBP regulating gene protein Tier 1.5 0.725 2 81.31 1 0       0 0   0 Anxiety 0.35244791107935663
P48764 SLC9A3 Sodium/hydrogen exchanger 3 Tier 1.5 0.725 1 65.94 1 0       0 0   0 congenital sodium diarrhea 0.6503153836708786
P41968 MC3R Melanocortin receptor 3 Tier 1.5 0.723 6 83.88 1 0       0 0   0 alcohol drinking 0.3298167673588826
P07942 LAMB1 Laminin subunit beta-1 Tier 1.5 0.72 3 76.69 1 0       0 0   1 cobblestone lissencephaly without muscular or ocular involvement 0.8016665947624902
Q9NZD1 GPRC5D G-protein coupled receptor family C group 5 member D Tier 1.5 0.716 2 76.06 1 0       0 0   0 multiple myeloma 0.5555243624684951
Q9BZV2 SLC19A3 Thiamine transporter 2 Tier 1.5 0.712 19 81.56 1 0       0 0   0 biotin-responsive basal ganglia disease 0.8189646480334981
Q9NR82 KCNQ5 Potassium voltage-gated channel subfamily KQT member 5 Tier 1.5 0.711 5 56.41 1 0       0 0   1 intellectual disability, autosomal dominant 46 0.7086662845211597
Q401N2 ZACN Ligand-gated cation channel ZACN Tier 1.5 0.711 9 77.56 1 0       0 0   0 atrial heart septal defect 0.20510272364083965
Q2M385 MPEG1 Macrophage-expressed gene 1 protein Tier 1.5 0.71 5 82.75 1 0       0 0   0 immunodeficiency 77 0.7043238859467001
Q8N6U8 GPR161 G-protein coupled receptor 161 Tier 1.5 0.708 2 68.62 1 0       0 0   0 medulloblastoma 0.583267884969527
P34995 PTGER1 Prostaglandin E2 receptor EP1 subtype Tier 1.5 0.707 1 74.81 1 0       0 0   0 erectile dysfunction 0.5684936888228123
Q8TDU6 GPBAR1 G-protein coupled bile acid receptor 1 Tier 1.5 0.703 5 80.44 1 0       0 0   0 cholelithiasis 0.13532265841527905
Q1HG43 DUOXA1 Dual oxidase maturation factor 1 Tier 1.5 0.703 2 82.44 1 0       0 0   0 familial thyroid dyshormonogenesis 0.33299144907091627
Q99705 MCHR1 Melanin-concentrating hormone receptor 1 Tier 1.5 0.702 10 84.44 1 0       0 0   0 carpal tunnel syndrome 0.3206604001931773
P14770 GP9 Platelet glycoprotein IX Tier 1.5 0.702 2 84.69 1 0       0 0   1 Bernard-Soulier syndrome 0.8233582238860002
P33032 MC5R Melanocortin receptor 5 Tier 1.5 0.693 3 82.62 1 0       0 0   0 color vision disorder 0.32934412559476917
P01825 IGHV4-59 Immunoglobulin heavy variable 4-59 Tier 1.5 0.69 3 91.56 1 0       0 0   1 cutaneous Leishmaniasis 0.5868213846274001
P25929 NPY1R Neuropeptide Y receptor type 1 Tier 1.5 0.69 6 79.88 1 0       0 0   0 mathematical ability 0.4585181664868048
Q16280 CNGA2 Cyclic nucleotide-gated channel alpha-2 Tier 1.5 0.689 2 77.75 1 0       0 0   0 neurodegenerative disease 0.3406621245682051
Q6NT16 SLC18B1 MFS-type transporter SLC18B1 Tier 1.5 0.688 4 84.62 1 0       0 0   1 Parkinson disease 0.276931649354752
Q99250 SCN2A Sodium channel protein type 2 subunit alpha Tier 1.5 0.685 5 68.81 1 0       0 0   1 developmental and epileptic encephalopathy, 11 0.8388748085806758
Q9UM01 SLC7A7 Y+L amino acid transporter 1 Tier 1.5 0.685 5 83.81 1 0       0 0   0 lysinuric protein intolerance 0.8450026270275782

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CREATE VIEW v_targets AS
SELECT f.id, n.gene_symbol, n.protein_name, tg.tier, f.priority_score,
 f.pdb_count_total, f.alphafold_mean_pLDDT, f.has_cryoEM,
 f.has_activation_state_pdb_pair, f.activation_state_pdb_active, f.activation_state_pdb_inactive,
 f.drug_count_approved, f.has_known_aptamer, f.aptamer_count_pubmed, ap.aptamer_pmids,
 f.in_cev_map, f.opentargets_top_disease_name, f.opentargets_top_disease_score
FROM v_target_full f
LEFT JOIN target_names n ON n.target_id=f.id
LEFT JOIN targets tg ON tg.id=f.id
LEFT JOIN target_aptamer_pmids ap ON ap.target_id=f.id;