Targets — browse / sort / filter (view)

One row per human protein target with names + key evidence. Click column headers to SORT; use the facets to FILTER (tier, activation pair, known aptamer, EV-Map). UniProt IDs link to the source.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

id
UniProt accession (human). Links to uniprot.org.
gene_symbol
Gene symbol (e.g. ITGB3).
protein_name
Protein name (UniProt).
tier
Tier 1 = PDB-anchored; Tier 1.5 = AlphaFold-confident.
priority_score
Composite prioritisation = 0.30*biology + 0.30*reagent-gap + 0.20*druggability + 0.10*disease + 0.10*novelty. Sub-scores are assigned during LLM-assisted curation — a heuristic ranking, NOT an experimental measurement.
has_activation_state_pdb_pair
1 if a curated ACTIVE/INACTIVE PDB pair exists (only 11 targets).
in_cev_map
1 if in the EV-Map circulating-EV proteome (Rai 2025); 3,422 targets.
has_known_aptamer
1 if aptamer evidence found in PubMed/Aptagen (1,472 targets).
opentargets_top_disease_score
Open Targets association score (0-1).
aptamer_count_pubmed
Number of PubMed hits for this protein AND (aptamer OR SELEX).
aptamer_pmids
The actual PubMed IDs behind the aptamer evidence — click each to read the paper. This is the source of the 'has aptamer' claim.

175 rows where has_cryoEM = 1, has_known_aptamer = 1 and in_cev_map = 0 sorted by priority_score descending

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tier 2

in_cev_map 1

has_known_aptamer 1

has_cryoEM 1

has_activation_state_pdb_pair 1

  • 0 175
id gene_symbol protein_name tier priority_score ▲ pdb_count_total alphafold_mean_pLDDT has_cryoEM has_activation_state_pdb_pair activation_state_pdb_active activation_state_pdb_inactive drug_count_approved has_known_aptamer aptamer_count_pubmed aptamer_pmids in_cev_map opentargets_top_disease_name opentargets_top_disease_score
P21583 KITLG Kit ligand Tier 1.5 0.848 6 71.88 1 0       1 2 36579647, 23967247 0 hyperpigmentation with or without hypopigmentation, familial progressive 0.6756727302967072
A0A0E3EAY4 env Envelope glycoprotein gp160 Tier 1 0.82 2   1 0       1 12 36576612, 29464116, 29217761, 22379083, 18776229, 18569791, 16146716, 16043495, 16013840, 12498773, 11024283, 9713975 0    
Q00975 CACNA1B Voltage-dependent N-type calcium channel subunit alpha-1B Tier 1.5 0.807 7 59.91 1 0       1 2 31118475, 25782368 0 Seizure 0.7217241968702018
P35414 APLNR Apelin receptor Tier 1 0.8 37 81.69 1 0       1 1 36126144 0 essential hypertension 0.2159614840844307
P03971 AMH Anti-Muellerian hormone Tier 1.5 0.783 3 68.62 1 0       1 2 41101154, 27364573 0 persistent Mullerian duct syndrome 0.7847328444470535
P07911 UMOD Uromodulin Tier 1 0.774 10 82.94 1 0       1 4 37533140, 35446786 0 familial juvenile hyperuricemic nephropathy type 1 0.8446536377993564
P40225 THPO Thrombopoietin Tier 1 0.76 3 61.44 1 0       1 2 38928037, 30312735 0 thrombocythemia 1 0.7027329039559379
Q9ULV1 FZD4 Frizzled-4 Tier 1 0.745 11 84.31 1 0       1 1 18673242 0 Familial exudative vitreoretinopathy 0.8152111103672746
P21730 C5AR1 C5a anaphylatoxin chemotactic receptor 1 Tier 1 0.741 19 85.75 1 0       1 5 33495506, 29981048, 29327939, 28288993, 25901944 0 anti-neutrophil cytoplasmic antibody-associated vasculitis 0.5076734733894334
Q00604 NDP Norrin Tier 1.5 0.716 11 83.56 1 0       1 2 39057719, 11352723 0 Norrie disease 0.8566451682188412
P46094 XCR1 Chemokine XC receptor 1 Tier 1.5 0.715 1 84.94 1 0       1 1 35212764 0 COVID-19 0.459103766220463
P32239 CCKBR Gastrin/cholecystokinin type B receptor Tier 1.5 0.713 5 75.75 1 0       1 2 33776434, 27754762 0 gastroesophageal reflux disease 0.4256110167566802
P20809 IL11 Interleukin-11 Tier 1 0.712 8 82.62 1 0       1 8 39408993, 39263947, 28791655, 27878687, 25696907, 24629635 0 osteoarthritis, hip 0.31754029889853136
P25106 ACKR3 Atypical chemokine receptor 3 Tier 1.5 0.71 14 82.44 1 0       1 2 40401615, 28670693 0 oculomotor-abducens synkinesis 0.49893280382434735
P15309 ACP3 Prostatic acid phosphatase Tier 1 0.695 17 92.25 1 0       1 3 41890985, 25591398 0 prostate cancer 0.5521391557206573
P48061 CXCL12 Stromal cell-derived factor 1 Tier 1 0.685 34 83.25 1 0       1 36 41951573, 41931849, 41907643, 41527798, 40401615, 40008515, 39865939, 39263947, 38806504, 38477735, 32784904, 31267721, 31097627, 30465210, 30385042, 29111236, 28963140, 28670693, 27940247, 27924617, 27392463, 26265085, 25560701, 25236655, 24526776, 24277076, 23615526, 22376154, 21147843, 41963275 0 HIV-1 infection 0.3675509850165065
Q6NW40 RGMB Repulsive guidance molecule B Tier 1 0.683 11 79.44 1 0       1 1 39263947 0 Abnormality of the skeletal system 0.42535629367019584
Q96RJ3 TNFRSF13C Tumor necrosis factor receptor superfamily member 13C Tier 1.5 0.681 8 63.03 1 0       1 1 23470998 0 immunodeficiency, common variable, 4 0.660711678987284
Q9UEF7 KL Klotho Tier 1 0.676 6 89.06 1 0       1 19 41978019, 41851110, 41038766, 40370992, 39975897, 39909827, 38500260, 38233588, 37584531, 36891771, 36535944, 35770801, 35360393, 34375633, 33536505, 31511614, 25325398, 18569791, 40514411 0 type 2 diabetes mellitus 0.5587488336100863
P51681 CCR5 C-C chemokine receptor type 5 Tier 1 0.674 25 85.38 1 0       1 23 36576612, 33981364, 29678881, 29556342, 29301363, 27807347, 27652575, 26965267, 25794434, 25754473, 25329893, 23629001, 22811524, 21576818, 18799178, 16631118, 16227301, 15813986, 14610191, 12498773 0 HIV infection 0.7442590579227027
P56704 WNT3A Protein Wnt-3a Tier 1 0.665 4 88.31 1 0       1 1 37231925 0 neurodegenerative disease 0.5271953966006525
P05113 IL5 Interleukin-5 Tier 1 0.664 5 86.69 1 0       1 12 40972397, 35487180, 35356877, 34831332, 32784904, 32038731, 29881374, 28062796, 26048585 0 asthma 0.6399821251487101
Q12809 KCNH2 Voltage-gated inwardly rectifying potassium channel KCNH2 Tier 1 0.655 23 62.75 1 0       1 1 22617876 0 Romano-Ward syndrome 0.8549238933917284
P08100 RHO Rhodopsin Tier 1.5 0.645 4 88.75 1 0       1 45 41963275, 41924874, 41636061, 40808302, 40642289, 40330320, 40045571, 39863313, 39788632, 38070612, 37191882, 36705086, 36696850, 36095194, 36049339, 35622174, 34709779, 34471566, 32696702, 32479610, 32319623, 32119944, 31737572, 31588238, 31535128, 29570714, 29281176, 28648779, 27893356, 25645980, 23757206, 23701883, 25033804, 22689339, 22302221, 22121695, 19766091, 19389625, 16419035, 12123800, 8743323, 7678562, 19188685, 18230760 0 retinitis pigmentosa 0.8481942240861982
P15391 CD19 B-lymphocyte antigen CD19 Tier 1.5 0.642 4 62.22 1 0       1 13 41079126, 40652441, 38661725, 38148412, 36095289, 35829681, 34680368, 34364920, 32401486, 31912987, 29928472, 21127492 0 immunodeficiency, common variable, 3 0.6821072538733047
Q13651 IL10RA Interleukin-10 receptor subunit alpha Tier 1 0.641 7 62.0 1 0       1 2 25870409, 25558474 0 Autosomal recessive early-onset inflammatory bowel disease 0.8151052076044897
Q8NEV9 IL27 Interleukin-27 subunit alpha Tier 1.5 0.641 4 75.62 1 0       1 2 35859339, 32784904 0 Crohn's disease 0.40963715551754365
P45844 ABCG1 ATP-binding cassette sub-family G member 1 Tier 1.5 0.639 5 81.12 1 0       1 1 41854184 0 neurodegenerative disease 0.3915225348167794
P51654 GPC3 Glypican-3 Tier 1.5 0.636 4 75.06 1 0       1 65 42083729, 41790019, 41653459, 41045695, 40825648, 40722645, 39998646, 39874791, 39608318, 39427046, 38910291, 38787447, 38621313, 38368644, 37665421, 36903516, 36457288, 36317566, 36072763, 35788872, 35699181, 35477501, 35051745, 34974867, 34306031, 33254049, 33080969, 32356075, 30347351, 30122918, 29675356, 29605994, 29277631, 27601357, 28263753 0 Simpson-Golabi-Behmel syndrome type 1 0.762708583613362
P31785 IL2RG Cytokine receptor common subunit gamma Tier 1.5 0.635 14 75.5 1 0       1 2 30800133, 33869115 0 gamma chain deficiency 0.8469997000418428
O95342 ABCB11 Bile salt export pump Tier 1.5 0.624 8 83.12 1 0       1 1 36313979 0 progressive familial intrahepatic cholestasis type 2 0.8372060401943777
O00206 TLR4 Toll-like receptor 4 Tier 1 0.621 15 89.19 1 0       1 32 41864915, 41444487, 40521190, 39897575, 38931862, 38742374, 38280803, 37360693, 36916435, 36908619, 35410404, 35402075, 35189346, 34831332, 32784904, 29910175, 29250957, 25483705 0 major depressive disorder 0.5065500149392951
O14625 CXCL11 C-X-C motif chemokine 11 Tier 1 0.62 2 79.94 1 0       1 4 36649818, 32784904, 30578658, 23935890 0 neoplasm 0.11537901464416651
P49238 CX3CR1 CX3C chemokine receptor 1 Tier 1.5 0.62 2 80.5 1 0       1 2 28727998 0 age-related macular degeneration 0.4006854573775187
Q06141 REG3A Regenerating islet-derived protein 3-alpha Tier 1.5 0.62 4 89.0 1 0       1 2 39695715, 24771595 0 alcohol drinking 0.29724052454892086
Q07325 CXCL9 C-X-C motif chemokine 9 Tier 1.5 0.617 1 87.44 1 0       1 7 42046114, 37395276, 35204399, 35018777, 33742062, 27959341, 27819142 0 neoplasm 0.1199067650750674
P41146 OPRL1 Nociceptin receptor Tier 1.5 0.61 4 82.31 1 0       1 1 14970396 0 neurodegenerative disease 0.4039002828932129
P15018 LIF Leukemia inhibitory factor Tier 1 0.605 5 87.12 1 0       1 38 41611413, 38359901, 37549567, 37175248, 36838669, 33640806, 32253765, 31791592, 31357280, 30771937, 30037541, 29289340, 28963578, 28763192, 27855943, 26877178, 26764106, 26695234, 26344338, 26113415, 25335821, 25311485, 25035238, 24716781, 22648816, 22471443, 27335672, 20673578, 20151395, 19803140, 18646283, 17315151, 16331583, 16053313, 11791582, 9823713, 39571081, 31461490 0 alcohol drinking 0.24197086949132446
P10636 MAPT Microtubule-associated protein tau Tier 1 0.605 100 49.22 1 0       1 9 40380000, 39241336, 38585969, 38397086, 37003060, 31900535, 30004544, 29268187 0 Pick disease 0.7600399335134378
P04201 MAS1 Proto-oncogene Mas Tier 1.5 0.605 3 83.5 1 0       1 10 40518278, 34016094, 30415442, 27936442, 23618401 0 Abnormality of the skeletal system 0.40450059258174326
P41231 P2RY2 P2Y purinoceptor 2 Tier 1.5 0.605 3 78.88 1 0       1 1 33911033 0 nontoxic goiter 0.43556889579550895
P46059 SLC15A1 Solute carrier family 15 member 1 Tier 1 0.603 3 87.0 1 0       1 1 26811678 0 cleft palate 0.3279926002389253
P13500 CCL2 C-C motif chemokine 2 Tier 1 0.6 14 86.94 1 0       1 34 42007960, 41360349, 41207524, 39422353, 39317671, 38016488, 34440571, 32784904, 31267721, 31039360, 30056058, 29111236, 28385802, 28315675, 28186566, 27878687, 27392463, 26868748, 25970072, 25901662, 25457849, 25457848, 25236655, 24694577, 24561613, 24481979, 21813474, 21147843, 19156777, 18997060, 18776253, 18258851, 11591377, 36508319 0 Crohn's disease 0.44619484388731423
Q8NER1 TRPV1 Transient receptor potential cation channel subfamily V member 1 Tier 1.5 0.6 8 71.94 1 0       1 2 40855286, 28604222 0 migraine disorder 0.6269329225883602
P0DSE1 TRA M1-specific T cell receptor alpha chain Tier 1.5 0.6 3 88.81 1 0       1 7 41693575, 41636061, 39837202, 37015819, 28860472, 25844955, 19457263 0    
P49682 CXCR3 C-X-C chemokine receptor type 3 Tier 1 0.595 12 80.56 1 0       1 2 27959341, 15938634 0 neoplasm 0.11982670035221332
Q9NP91 SLC6A20 Sodium- and chloride-dependent transporter XTRP3 Tier 1 0.594 10 93.12 1 0       1 1 35212764 0 COVID-19 0.5415298766216101
P41159 LEP Leptin Tier 1 0.582 10 81.12 1 0       1 14 40330320, 40008515, 39263947, 37331044, 36508319, 36173490, 35884340, 34016094, 33650854, 32527800, 27530235, 26529285, 23232067, 20594164 0 obesity due to congenital leptin deficiency 0.7197450249224271
Q9BYF1 ACE2 Angiotensin-converting enzyme 2 Tier 1 0.58 100 90.69 1 0       1 91 41716474, 41541792, 41274248, 40642289, 40333723, 40321580, 40227272, 39964138, 39923730, 39281706, 38973558, 38553521, 37932762, 37808754, 37692001, 37666993, 37385465, 37375202, 36950312, 36822303, 36714461, 36683236, 36581924, 36073793, 35972202, 35910791, 35907639, 35542182, 34876524, 34855379, 34847324, 34798263, 34696413, 34619249, 34458322, 34282416, 34248841, 34230708, 34230707, 34166652, 34123223, 33684258, 33683787, 33629859, 33561300, 33389440, 32981365, 32838280, 32551560, 36288301, 36170362, 35748608, 34953639 0 COVID-19 0.6925739512122528
P55259 GP2 Pancreatic secretory granule membrane major glycoprotein GP2 Tier 1.5 0.577 4 78.62 1 0       1 3 36902059, 25483705, 24334484 0 type 2 diabetes mellitus 0.5235291484788168

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CREATE VIEW v_targets AS
SELECT f.id, n.gene_symbol, n.protein_name, tg.tier, f.priority_score,
 f.pdb_count_total, f.alphafold_mean_pLDDT, f.has_cryoEM,
 f.has_activation_state_pdb_pair, f.activation_state_pdb_active, f.activation_state_pdb_inactive,
 f.drug_count_approved, f.has_known_aptamer, f.aptamer_count_pubmed, ap.aptamer_pmids,
 f.in_cev_map, f.opentargets_top_disease_name, f.opentargets_top_disease_score
FROM v_target_full f
LEFT JOIN target_names n ON n.target_id=f.id
LEFT JOIN targets tg ON tg.id=f.id
LEFT JOIN target_aptamer_pmids ap ON ap.target_id=f.id;