Targets — browse / sort / filter (view)

One row per human protein target with names + key evidence. Click column headers to SORT; use the facets to FILTER (tier, activation pair, known aptamer, EV-Map). UniProt IDs link to the source.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

id
UniProt accession (human). Links to uniprot.org.
gene_symbol
Gene symbol (e.g. ITGB3).
protein_name
Protein name (UniProt).
tier
Tier 1 = PDB-anchored; Tier 1.5 = AlphaFold-confident.
priority_score
Composite prioritisation = 0.30*biology + 0.30*reagent-gap + 0.20*druggability + 0.10*disease + 0.10*novelty. Sub-scores are assigned during LLM-assisted curation — a heuristic ranking, NOT an experimental measurement.
has_activation_state_pdb_pair
1 if a curated ACTIVE/INACTIVE PDB pair exists (only 11 targets).
in_cev_map
1 if in the EV-Map circulating-EV proteome (Rai 2025); 3,422 targets.
has_known_aptamer
1 if aptamer evidence found in PubMed/Aptagen (1,472 targets).
opentargets_top_disease_score
Open Targets association score (0-1).
aptamer_count_pubmed
Number of PubMed hits for this protein AND (aptamer OR SELEX).
aptamer_pmids
The actual PubMed IDs behind the aptamer evidence — click each to read the paper. This is the source of the 'has aptamer' claim.

102 rows where has_cryoEM = 1, has_known_aptamer = 1 and tier = "Tier 1.5" sorted by priority_score descending

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Suggested facets: pdb_count_total, aptamer_count_pubmed

in_cev_map 2

  • 1 52
  • 0 50

tier 1

  • Tier 1.5 · 102 ✖

has_known_aptamer 1

has_cryoEM 1

has_activation_state_pdb_pair 1

  • 0 102
id gene_symbol protein_name tier priority_score ▲ pdb_count_total alphafold_mean_pLDDT has_cryoEM has_activation_state_pdb_pair activation_state_pdb_active activation_state_pdb_inactive drug_count_approved has_known_aptamer aptamer_count_pubmed aptamer_pmids in_cev_map opentargets_top_disease_name opentargets_top_disease_score
P25445 FAS Tumor necrosis factor receptor superfamily member 6 Tier 1.5 0.914 7 77.88 1 0       1 17 40784034, 39897575, 37458448, 36908619, 35402075, 32270033, 31436946, 30594071, 30417194, 30339905, 26318819, 23980164, 23511245, 18997060, 18956014, 16729304, 16581027 1 autoimmune lymphoproliferative syndrome type 1 0.7377210386590284
P21583 KITLG Kit ligand Tier 1.5 0.848 6 71.88 1 0       1 2 36579647, 23967247 0 hyperpigmentation with or without hypopigmentation, familial progressive 0.6756727302967072
Q00975 CACNA1B Voltage-dependent N-type calcium channel subunit alpha-1B Tier 1.5 0.807 7 59.91 1 0       1 2 31118475, 25782368 0 Seizure 0.7217241968702018
P02748 C9 Complement component C9 Tier 1.5 0.796 9 78.75 1 0       1 10 41636061, 40411682, 36428893, 36290981, 35247355, 28794177, 27836219, 22678933, 19261617, 15687383 1 Immunodeficiency due to a late component of complements deficiency 0.761965409699055
Q13085 ACACA Acetyl-CoA carboxylase 1 Tier 1.5 0.79 10 82.81 1 0       1 1 41854184 1    
Q92633 LPAR1 Lysophosphatidic acid receptor 1 Tier 1.5 0.785 16 83.62 1 0       1 1 32065590 1 Epiretinal membrane 0.4757255248053499
P03971 AMH Anti-Muellerian hormone Tier 1.5 0.783 3 68.62 1 0       1 2 41101154, 27364573 0 persistent Mullerian duct syndrome 0.7847328444470535
P39060 COL18A1 Collagen alpha-1(XVIII) chain Tier 1.5 0.769 9 50.62 1 0       1 2 36707842, 23679916 1 Knobloch syndrome 1 0.7867122552672962
P43007 SLC1A4 Neutral amino acid transporter A Tier 1.5 0.75 1 80.56 1 0       1 6 36219068, 31989939, 27571928, 26811678, 19046328, 16139842 1 spastic tetraplegia-thin corpus callosum-progressive postnatal microcephaly syndrome 0.8025684205131692
P08648 ITGA5 Integrin alpha-5 Tier 1.5 0.748 14 85.25 1 0       1 2 32174798, 38258032 1 skin disease 0.28465651599598124
O60884 DNAJA2 DnaJ homolog subfamily A member 2 Tier 1.5 0.73 1 83.38 1 0       1 2 41935727, 33879515 1 dengue disease 0.37068859424875583
Q99988 GDF15 Growth/differentiation factor 15 Tier 1.5 0.718 4 75.69 1 0       1 29 41924874, 41862097, 38879214, 38477735, 37982669, 36927042, 36638554, 36508319, 36333824, 35762561, 33334063, 32527800, 31988066, 29992704, 39884764, 38497478, 38296402, 37162508, 32739349, 30335547 1 hyperemesis gravidarum 0.5821658682742563
Q00604 NDP Norrin Tier 1.5 0.716 11 83.56 1 0       1 2 39057719, 11352723 0 Norrie disease 0.8566451682188412
P46094 XCR1 Chemokine XC receptor 1 Tier 1.5 0.715 1 84.94 1 0       1 1 35212764 0 COVID-19 0.459103766220463
P32239 CCKBR Gastrin/cholecystokinin type B receptor Tier 1.5 0.713 5 75.75 1 0       1 2 33776434, 27754762 0 gastroesophageal reflux disease 0.4256110167566802
P25106 ACKR3 Atypical chemokine receptor 3 Tier 1.5 0.71 14 82.44 1 0       1 2 40401615, 28670693 0 oculomotor-abducens synkinesis 0.49893280382434735
P07225 PROS1 Vitamin K-dependent protein S Tier 1.5 0.7 3 82.94 1 0       1 2 36859809, 33674695 1 thrombophilia due to protein S deficiency, autosomal dominant 0.8240418292042652
P21359 NF1 Neurofibromin Tier 1.5 0.695 26 87.19 1 0       1 2 32980430, 22617876 1 neurofibromatosis type 1 0.8844735398780649
Q96RJ3 TNFRSF13C Tumor necrosis factor receptor superfamily member 13C Tier 1.5 0.681 8 63.03 1 0       1 1 23470998 0 immunodeficiency, common variable, 4 0.660711678987284
P98155 VLDLR Very low-density lipoprotein receptor Tier 1.5 0.66 27 75.69 1 0       1 1 19188685 1 Dysequilibrium syndrome 0.790164037509625
P16234 PDGFRA Platelet-derived growth factor receptor alpha Tier 1.5 0.652 14 72.69 1 0       1 4 33334063, 32127469, 28010895, 30594071 1 gastrointestinal stromal tumor 0.8167494524079806
P08100 RHO Rhodopsin Tier 1.5 0.645 4 88.75 1 0       1 45 41963275, 41924874, 41636061, 40808302, 40642289, 40330320, 40045571, 39863313, 39788632, 38070612, 37191882, 36705086, 36696850, 36095194, 36049339, 35622174, 34709779, 34471566, 32696702, 32479610, 32319623, 32119944, 31737572, 31588238, 31535128, 29570714, 29281176, 28648779, 27893356, 25645980, 23757206, 23701883, 25033804, 22689339, 22302221, 22121695, 19766091, 19389625, 16419035, 12123800, 8743323, 7678562, 19188685, 18230760 0 retinitis pigmentosa 0.8481942240861982
P07237 P4HB Protein disulfide-isomerase Tier 1.5 0.644 14 88.5 1 0       1 2 31625090, 28952381 1 Cole-Carpenter syndrome 0.7447295842045853
P15391 CD19 B-lymphocyte antigen CD19 Tier 1.5 0.642 4 62.22 1 0       1 13 41079126, 40652441, 38661725, 38148412, 36095289, 35829681, 34680368, 34364920, 32401486, 31912987, 29928472, 21127492 0 immunodeficiency, common variable, 3 0.6821072538733047
Q8NEV9 IL27 Interleukin-27 subunit alpha Tier 1.5 0.641 4 75.62 1 0       1 2 35859339, 32784904 0 Crohn's disease 0.40963715551754365
P45844 ABCG1 ATP-binding cassette sub-family G member 1 Tier 1.5 0.639 5 81.12 1 0       1 1 41854184 0 neurodegenerative disease 0.3915225348167794
P51654 GPC3 Glypican-3 Tier 1.5 0.636 4 75.06 1 0       1 65 42083729, 41790019, 41653459, 41045695, 40825648, 40722645, 39998646, 39874791, 39608318, 39427046, 38910291, 38787447, 38621313, 38368644, 37665421, 36903516, 36457288, 36317566, 36072763, 35788872, 35699181, 35477501, 35051745, 34974867, 34306031, 33254049, 33080969, 32356075, 30347351, 30122918, 29675356, 29605994, 29277631, 27601357, 28263753 0 Simpson-Golabi-Behmel syndrome type 1 0.762708583613362
P31785 IL2RG Cytokine receptor common subunit gamma Tier 1.5 0.635 14 75.5 1 0       1 2 30800133, 33869115 0 gamma chain deficiency 0.8469997000418428
O75976 CPD Carboxypeptidase D Tier 1.5 0.625 3 82.5 1 0       1 1 36457699 1 neurodegenerative disease 0.34777406871587735
O95342 ABCB11 Bile salt export pump Tier 1.5 0.624 8 83.12 1 0       1 1 36313979 0 progressive familial intrahepatic cholestasis type 2 0.8372060401943777
P49238 CX3CR1 CX3C chemokine receptor 1 Tier 1.5 0.62 2 80.5 1 0       1 2 28727998 0 age-related macular degeneration 0.4006854573775187
Q06141 REG3A Regenerating islet-derived protein 3-alpha Tier 1.5 0.62 4 89.0 1 0       1 2 39695715, 24771595 0 alcohol drinking 0.29724052454892086
Q9ULC3 RAB23 Ras-related protein Rab-23 Tier 1.5 0.619 6 79.56 1 0       1 1 23618401 1 RAB23-related Carpenter syndrome 0.7879955689930709
Q07325 CXCL9 C-X-C motif chemokine 9 Tier 1.5 0.617 1 87.44 1 0       1 7 42046114, 37395276, 35204399, 35018777, 33742062, 27959341, 27819142 0 neoplasm 0.1199067650750674
P01876 IGHA1 Immunoglobulin heavy constant alpha 1 Tier 1.5 0.612 14 81.88 1 0       1 2 37325361 1 IGA glomerulonephritis 0.12053726815801102
O43866 CD5L CD5 antigen-like Tier 1.5 0.61 4 85.88 1 0       1 3 40215752, 37100807 1 functional neutrophil defect 0.3529395470693119
P41146 OPRL1 Nociceptin receptor Tier 1.5 0.61 4 82.31 1 0       1 1 14970396 0 neurodegenerative disease 0.4039002828932129
P23368 ME2 NAD-dependent malic enzyme, mitochondrial Tier 1.5 0.61 18 94.38 1 0       1 2 39602246, 29779113 1 diabetes mellitus 0.277416610655893
P15529 CD46 Membrane cofactor protein Tier 1.5 0.608 7 82.12 1 0       1 9 35114109, 34248841, 31761039, 31077760, 27734375, 19915929, 17046833, 11084032 1 atypical hemolytic-uremic syndrome with MCP/CD46 anomaly 0.7798469882597787
P55157 MTTP Microsomal triglyceride transfer protein large subunit Tier 1.5 0.608 2 86.56 1 0       1 1 23770039 1 abetalipoproteinemia 0.8281089516017405
P04201 MAS1 Proto-oncogene Mas Tier 1.5 0.605 3 83.5 1 0       1 10 40518278, 34016094, 30415442, 27936442, 23618401 0 Abnormality of the skeletal system 0.40450059258174326
P10646 TFPI Tissue factor pathway inhibitor Tier 1.5 0.605 9 73.62 1 0       1 28 32366845, 32224381, 30994257, 30302740, 27563744, 27196067, 24263002, 23528042, 22951415, 22658294, 22632032, 22239993, 21696535, 21389323, 8578509, 25521966, 24319161 1 hemophilia A 0.5591056672248635
P41231 P2RY2 P2Y purinoceptor 2 Tier 1.5 0.605 3 78.88 1 0       1 1 33911033 0 nontoxic goiter 0.43556889579550895
Q8NER1 TRPV1 Transient receptor potential cation channel subfamily V member 1 Tier 1.5 0.6 8 71.94 1 0       1 2 40855286, 28604222 0 migraine disorder 0.6269329225883602
P0DSE1 TRA M1-specific T cell receptor alpha chain Tier 1.5 0.6 3 88.81 1 0       1 7 41693575, 41636061, 39837202, 37015819, 28860472, 25844955, 19457263 0    
P02786 TFRC Transferrin receptor protein 1 Tier 1.5 0.587 22 86.69 1 0       1 3 39831311, 29046922, 32527800 1 TFRC-related combined immunodeficiency 0.623449899069336
P31948 STIP1 Stress-induced-phosphoprotein 1 Tier 1.5 0.585 8 89.75 1 0       1 7 41406518, 38012811, 34831332, 32614006, 27681499, 24654750, 24013070 1 neurodegenerative disease 0.4967711525222825
Q15813 TBCE Tubulin-specific chaperone E Tier 1.5 0.582 6 89.19 1 0       1 1 34448574 1 hypoparathyroidism-retardation-dysmorphism syndrome 0.7744447925917005
P55259 GP2 Pancreatic secretory granule membrane major glycoprotein GP2 Tier 1.5 0.577 4 78.62 1 0       1 3 36902059, 25483705, 24334484 0 type 2 diabetes mellitus 0.5235291484788168
P08887 IL6R Interleukin-6 receptor subunit alpha Tier 1.5 0.575 10 77.88 1 0       1 18 40853309, 38152968, 37034659, 36579647, 35890412, 33590853, 33340765, 32515246, 29211023, 28929152, 26552813, 26383776, 24481022, 24440854, 23235494, 22503683, 22258147, 22094809 0 rheumatoid arthritis 0.7269057706798291

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CREATE VIEW v_targets AS
SELECT f.id, n.gene_symbol, n.protein_name, tg.tier, f.priority_score,
 f.pdb_count_total, f.alphafold_mean_pLDDT, f.has_cryoEM,
 f.has_activation_state_pdb_pair, f.activation_state_pdb_active, f.activation_state_pdb_inactive,
 f.drug_count_approved, f.has_known_aptamer, f.aptamer_count_pubmed, ap.aptamer_pmids,
 f.in_cev_map, f.opentargets_top_disease_name, f.opentargets_top_disease_score
FROM v_target_full f
LEFT JOIN target_names n ON n.target_id=f.id
LEFT JOIN targets tg ON tg.id=f.id
LEFT JOIN target_aptamer_pmids ap ON ap.target_id=f.id;