Targets — browse / sort / filter (view)

One row per human protein target with names + key evidence. Click column headers to SORT; use the facets to FILTER (tier, activation pair, known aptamer, EV-Map). UniProt IDs link to the source.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

id
UniProt accession (human). Links to uniprot.org.
gene_symbol
Gene symbol (e.g. ITGB3).
protein_name
Protein name (UniProt).
tier
Tier 1 = PDB-anchored; Tier 1.5 = AlphaFold-confident.
priority_score
Composite prioritisation = 0.30*biology + 0.30*reagent-gap + 0.20*druggability + 0.10*disease + 0.10*novelty. Sub-scores are assigned during LLM-assisted curation — a heuristic ranking, NOT an experimental measurement.
has_activation_state_pdb_pair
1 if a curated ACTIVE/INACTIVE PDB pair exists (only 11 targets).
in_cev_map
1 if in the EV-Map circulating-EV proteome (Rai 2025); 3,422 targets.
has_known_aptamer
1 if aptamer evidence found in PubMed/Aptagen (1,472 targets).
opentargets_top_disease_score
Open Targets association score (0-1).
aptamer_count_pubmed
Number of PubMed hits for this protein AND (aptamer OR SELEX).
aptamer_pmids
The actual PubMed IDs behind the aptamer evidence — click each to read the paper. This is the source of the 'has aptamer' claim.

522 rows where has_cryoEM = 1, in_cev_map = 0 and tier = "Tier 1" sorted by priority_score descending

✎ View and edit SQL

This data as json, CSV (advanced)

has_known_aptamer 2

  • 0 397
  • 1 125

tier 1

  • Tier 1 · 522 ✖

in_cev_map 1

has_cryoEM 1

has_activation_state_pdb_pair 1

  • 0 522
id gene_symbol protein_name tier priority_score ▲ pdb_count_total alphafold_mean_pLDDT has_cryoEM has_activation_state_pdb_pair activation_state_pdb_active activation_state_pdb_inactive drug_count_approved has_known_aptamer aptamer_count_pubmed aptamer_pmids in_cev_map opentargets_top_disease_name opentargets_top_disease_score
P12263     Tier 1 0.9 7 63.59 1 0       0 0   0    
Q12879 GRIN2A Glutamate receptor ionotropic, NMDA 2A Tier 1 0.88 37 60.84 1 0       0 0   0 Landau-Kleffner syndrome 0.8407159711916629
Q5T848 GPR158 Metabotropic glycine receptor Tier 1 0.839 6 58.03 1 0       0 0   0 diverticular disease 0.4384404783771627
P0DSE2 TRB M1-specific T cell receptor beta chain Tier 1 0.83 5 90.12 1 0       0 0   0    
A0A0E3EAY4 env Envelope glycoprotein gp160 Tier 1 0.82 2   1 0       1 12 36576612, 29464116, 29217761, 22379083, 18776229, 18569791, 16146716, 16043495, 16013840, 12498773, 11024283, 9713975 0    
Q9NS82 SLC7A10 Asc-type amino acid transporter 1 Tier 1 0.803 4 83.38 1 0       0 0   0 asthma 0.5295411410172121
O60895 RAMP2 Receptor activity-modifying protein 2 Tier 1 0.802 10 80.94 1 0       0 0   0 diabetes mellitus 0.4219370007650345
P35414 APLNR Apelin receptor Tier 1 0.8 37 81.69 1 0       1 1 36126144 0 essential hypertension 0.2159614840844307
P01909 HLA-DQA1 HLA class II histocompatibility antigen, DQ alpha 1 chain Tier 1 0.792 27 87.94 1 0       0 0   0 Pleural Mesothelioma 0.1228600330569846
Q13639     Tier 1 0.781 3 80.88 1 0       0 0   0 schizophrenia 0.6060830827022777
O15393     Tier 1 0.775 31 79.38 1 0       0 0   0 COVID-19 0.6157541390484623
P07911 UMOD Uromodulin Tier 1 0.774 10 82.94 1 0       1 4 37533140, 35446786 0 familial juvenile hyperuricemic nephropathy type 1 0.8446536377993564
P29460 IL12B Interleukin-12 subunit beta Tier 1 0.769 20 91.12 1 0       0 0   0 psoriasis 0.7914863943708039
P98073     Tier 1 0.761 14 81.5 1 0       0 0   0 congenital enteropathy due to enteropeptidase deficiency 0.7102613227574134
P40225 THPO Thrombopoietin Tier 1 0.76 3 61.44 1 0       1 2 38928037, 30312735 0 thrombocythemia 1 0.7027329039559379
O75762 TRPA1 Transient receptor potential cation channel subfamily A member 1 Tier 1 0.76 17 81.94 1 0       0 0   0 familial episodic pain syndrome with predominantly upper body involvement 0.6615353934604322
O43614     Tier 1 0.75 11 78.94 1 0       0 0   0 insomnia 0.5988748728311054
Q9ULV1 FZD4 Frizzled-4 Tier 1 0.745 11 84.31 1 0       1 1 18673242 0 Familial exudative vitreoretinopathy 0.8152111103672746
O43526 KCNQ2 Potassium voltage-gated channel subfamily KQT member 2 Tier 1 0.744 24 58.19 1 0       0 0   0 Benign familial neonatal seizures 0.8423358217314708
Q8N158 GPC2 Glypican-2 Tier 1 0.744 2 79.06 1 0       0 0   0 COVID-19 0.5409211817593593
O15245 SLC22A1 Solute carrier family 22 member 1 Tier 1 0.744 16 84.25 1 0       0 0   0 coronary artery disease 0.5384890077265535
P40879 SLC26A3 Chloride anion exchanger Tier 1 0.742 13 85.06 1 0       0 0   0 congenital secretory chloride diarrhea 1 0.8189631913308207
P21730 C5AR1 C5a anaphylatoxin chemotactic receptor 1 Tier 1 0.741 19 85.75 1 0       1 5 33495506, 29981048, 29327939, 28288993, 25901944 0 anti-neutrophil cytoplasmic antibody-associated vasculitis 0.5076734733894334
D7RIG0 HLA-DRB1   Tier 1 0.74 10 84.94 1 0       0 0   0    
A0A1B0GX56 TRDV1 T cell receptor delta variable 1 Tier 1 0.737 7 90.69 1 0       0 0   0 colorectal carcinoma 0.07391597093694036
Q14028 CNGB1 Cyclic nucleotide-gated channel beta-1 Tier 1 0.734 11 57.66 1 0       0 0   0 retinitis pigmentosa 0.7931901344765326
P41145 OPRK1 Kappa-type opioid receptor Tier 1 0.725 28 79.5 1 0       0 0   0 alcohol dependence 0.6106562988740131
P23416 GLRA2 Glycine receptor subunit alpha-2 Tier 1 0.723 13 83.81 1 0       0 0   0 intellectual developmental disorder, X-linked, syndromic, Pilorge type 0.7805605973560554
B7Z8K6 TRDC T cell receptor delta constant Tier 1 0.72 12 81.38 1 0       0 0   0    
P29033 GJB2 Gap junction beta-2 protein Tier 1 0.72 24 86.19 1 0       0 0   0 palmoplantar keratoderma-deafness syndrome 0.8149616697051898
Q695T7 SLC6A19 Sodium-dependent neutral amino acid transporter B(0)AT1 Tier 1 0.715 19 90.0 1 0       0 0   0 Hartnup disease 0.8464240093600148
A0A0B4J271 TRAV12-3 T cell receptor alpha variable 12-3 Tier 1 0.715 12 92.56 1 0       0 0   0 ulcerative colitis 0.003139210371371825
P20809 IL11 Interleukin-11 Tier 1 0.712 8 82.62 1 0       1 8 39408993, 39263947, 28791655, 27878687, 25696907, 24629635 0 osteoarthritis, hip 0.31754029889853136
P49019 HCAR3 Hydroxycarboxylic acid receptor 3 Tier 1 0.709 11 79.19 1 0       0 0   0 Oral ulcer 0.3943093179045574
O15342 ATP6V0E1 V-type proton ATPase subunit e 1 Tier 1 0.708 9 92.88 1 0       0 0   0 multiple myeloma 0.18220286553988743
Q9BXJ8 TMEM120A Transmembrane protein 120A Tier 1 0.706 5 89.25 1 0       0 0   0 congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency 0.1609725589293368
P22888 LHCGR Lutropin-choriogonadotropic hormone receptor Tier 1 0.698 4 80.12 1 0       0 0   0 Leydig cell hypoplasia, type 1 0.783461117057047
P30989 NTSR1 Neurotensin receptor type 1 Tier 1 0.695 24 79.62 1 0       0 0   0 Cough 0.31206841983343936
Q07699 SCN1B Sodium channel regulatory subunit beta-1 Tier 1 0.695 36 87.06 1 0       0 0   0 Generalized epilepsy with febrile seizures-plus 0.7638796221342504
P15309 ACP3 Prostatic acid phosphatase Tier 1 0.695 17 92.25 1 0       1 3 41890985, 25591398 0 prostate cancer 0.5521391557206573
P48061 CXCL12 Stromal cell-derived factor 1 Tier 1 0.685 34 83.25 1 0       1 36 41951573, 41931849, 41907643, 41527798, 40401615, 40008515, 39865939, 39263947, 38806504, 38477735, 32784904, 31267721, 31097627, 30465210, 30385042, 29111236, 28963140, 28670693, 27940247, 27924617, 27392463, 26265085, 25560701, 25236655, 24526776, 24277076, 23615526, 22376154, 21147843, 41963275 0 HIV-1 infection 0.3675509850165065
Q6NW40 RGMB Repulsive guidance molecule B Tier 1 0.683 11 79.44 1 0       1 1 39263947 0 Abnormality of the skeletal system 0.42535629367019584
Q96RJ0 TAAR1 Trace amine-associated receptor 1 Tier 1 0.68 17 90.06 1 0       0 0   0 schizophrenia 0.41827765417829765
Q14973 SLC10A1 Hepatic sodium/bile acid cotransporter Tier 1 0.679 11 83.5 1 0       0 0   0 hypercholanemia, familial, 2 0.6937781800382379
Q9UEF7 KL Klotho Tier 1 0.676 6 89.06 1 0       1 19 41978019, 41851110, 41038766, 40370992, 39975897, 39909827, 38500260, 38233588, 37584531, 36891771, 36535944, 35770801, 35360393, 34375633, 33536505, 31511614, 25325398, 18569791, 40514411 0 type 2 diabetes mellitus 0.5587488336100863
O15399 GRIN2D Glutamate receptor ionotropic, NMDA 2D Tier 1 0.675 13 63.22 1 0       0 0   0 developmental and epileptic encephalopathy, 46 0.7529662497608808
P51681 CCR5 C-C chemokine receptor type 5 Tier 1 0.674 25 85.38 1 0       1 23 36576612, 33981364, 29678881, 29556342, 29301363, 27807347, 27652575, 26965267, 25794434, 25754473, 25329893, 23629001, 22811524, 21576818, 18799178, 16631118, 16227301, 15813986, 14610191, 12498773 0 HIV infection 0.7442590579227027
Q05586 GRIN1 Glutamate receptor ionotropic, NMDA 1 Tier 1 0.67 84 82.88 1 0       0 0   0 neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant 0.8446685494288694
Q99679 GPR21 Probable G-protein coupled receptor 21 Tier 1 0.67 5 83.12 1 0       0 0   0 type 2 diabetes mellitus 0.10141298237734184
Q8TDV5 GPR119 Glucose-dependent insulinotropic receptor Tier 1 0.67 9 86.75 1 0       0 0   0 neurodegenerative disease 0.2992783744181862

Next page

Advanced export

JSON shape: default, array, newline-delimited

CSV options: 

CREATE VIEW v_targets AS
SELECT f.id, n.gene_symbol, n.protein_name, tg.tier, f.priority_score,
 f.pdb_count_total, f.alphafold_mean_pLDDT, f.has_cryoEM,
 f.has_activation_state_pdb_pair, f.activation_state_pdb_active, f.activation_state_pdb_inactive,
 f.drug_count_approved, f.has_known_aptamer, f.aptamer_count_pubmed, ap.aptamer_pmids,
 f.in_cev_map, f.opentargets_top_disease_name, f.opentargets_top_disease_score
FROM v_target_full f
LEFT JOIN target_names n ON n.target_id=f.id
LEFT JOIN targets tg ON tg.id=f.id
LEFT JOIN target_aptamer_pmids ap ON ap.target_id=f.id;