Targets — browse / sort / filter (view)

One row per human protein target with names + key evidence. Click column headers to SORT; use the facets to FILTER (tier, activation pair, known aptamer, EV-Map). UniProt IDs link to the source.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

id
UniProt accession (human). Links to uniprot.org.
gene_symbol
Gene symbol (e.g. ITGB3).
protein_name
Protein name (UniProt).
tier
Tier 1 = PDB-anchored; Tier 1.5 = AlphaFold-confident.
priority_score
Composite prioritisation = 0.30*biology + 0.30*reagent-gap + 0.20*druggability + 0.10*disease + 0.10*novelty. Sub-scores are assigned during LLM-assisted curation — a heuristic ranking, NOT an experimental measurement.
has_activation_state_pdb_pair
1 if a curated ACTIVE/INACTIVE PDB pair exists (only 11 targets).
in_cev_map
1 if in the EV-Map circulating-EV proteome (Rai 2025); 3,422 targets.
has_known_aptamer
1 if aptamer evidence found in PubMed/Aptagen (1,472 targets).
opentargets_top_disease_score
Open Targets association score (0-1).
aptamer_count_pubmed
Number of PubMed hits for this protein AND (aptamer OR SELEX).
aptamer_pmids
The actual PubMed IDs behind the aptamer evidence — click each to read the paper. This is the source of the 'has aptamer' claim.

239 rows where has_cryoEM = 1, in_cev_map = 1 and tier = "Tier 1.5" sorted by priority_score descending

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Suggested facets: pdb_count_total, aptamer_count_pubmed

has_known_aptamer 2

  • 0 187
  • 1 52

tier 1

  • Tier 1.5 · 239 ✖

in_cev_map 1

has_cryoEM 1

has_activation_state_pdb_pair 1

  • 0 239
id gene_symbol protein_name tier priority_score ▲ pdb_count_total alphafold_mean_pLDDT has_cryoEM has_activation_state_pdb_pair activation_state_pdb_active activation_state_pdb_inactive drug_count_approved has_known_aptamer aptamer_count_pubmed aptamer_pmids in_cev_map opentargets_top_disease_name opentargets_top_disease_score
P25445 FAS Tumor necrosis factor receptor superfamily member 6 Tier 1.5 0.914 7 77.88 1 0       1 17 40784034, 39897575, 37458448, 36908619, 35402075, 32270033, 31436946, 30594071, 30417194, 30339905, 26318819, 23980164, 23511245, 18997060, 18956014, 16729304, 16581027 1 autoimmune lymphoproliferative syndrome type 1 0.7377210386590284
Q02094 RHAG Ammonium transporter Rh type A Tier 1.5 0.841 8 95.62 1 0       0 0   1 Rh deficiency syndrome 0.764209214915708
Q14392 LRRC32 Transforming growth factor beta activator LRRC32 Tier 1.5 0.838 6 86.06 1 0       0 0   1 cleft palate, proliferative retinopathy, and developmental delay 0.5770707112957068
P12532 CKMT1A Creatine kinase U-type, mitochondrial Tier 1.5 0.83 9 89.31 1 0       0 0   1 neurodegenerative disease 0.5385822922582763
P54709 ATP1B3 Sodium/potassium-transporting ATPase subunit beta-3 Tier 1.5 0.81 7 89.69 1 0       0 0   1 congestive heart failure 0.5999952111132625
P02748 C9 Complement component C9 Tier 1.5 0.796 9 78.75 1 0       1 10 41636061, 40411682, 36428893, 36290981, 35247355, 28794177, 27836219, 22678933, 19261617, 15687383 1 Immunodeficiency due to a late component of complements deficiency 0.761965409699055
Q13085 ACACA Acetyl-CoA carboxylase 1 Tier 1.5 0.79 10 82.81 1 0       1 1 41854184 1    
Q92633 LPAR1 Lysophosphatidic acid receptor 1 Tier 1.5 0.785 16 83.62 1 0       1 1 32065590 1 Epiretinal membrane 0.4757255248053499
P39060 COL18A1 Collagen alpha-1(XVIII) chain Tier 1.5 0.769 9 50.62 1 0       1 2 36707842, 23679916 1 Knobloch syndrome 1 0.7867122552672962
O60568 PLOD3 Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 Tier 1.5 0.762 18 91.38 1 0       0 0   1 bone fragility with contractures, arterial rupture, and deafness 0.7159150369336311
P41440 SLC19A1 Reduced folate transporter Tier 1.5 0.755 19 72.06 1 0       0 0   1 Knobloch syndrome 0.5526223217595396
P43007 SLC1A4 Neutral amino acid transporter A Tier 1.5 0.75 1 80.56 1 0       1 6 36219068, 31989939, 27571928, 26811678, 19046328, 16139842 1 spastic tetraplegia-thin corpus callosum-progressive postnatal microcephaly syndrome 0.8025684205131692
P26022 PTX3 Pentraxin-related protein PTX3 Tier 1.5 0.75 9 76.75 1 0       0 0   1 polycystic ovary syndrome 0.12287624125782433
P08648 ITGA5 Integrin alpha-5 Tier 1.5 0.748 14 85.25 1 0       1 2 32174798, 38258032 1 skin disease 0.28465651599598124
Q9Y653 ADGRG1 Adhesion G-protein coupled receptor G1 Tier 1.5 0.743 1 77.88 1 0       0 0   1 bilateral frontoparietal polymicrogyria 0.8322298896713178
O60884 DNAJA2 DnaJ homolog subfamily A member 2 Tier 1.5 0.73 1 83.38 1 0       1 2 41935727, 33879515 1 dengue disease 0.37068859424875583
P07942 LAMB1 Laminin subunit beta-1 Tier 1.5 0.72 3 76.69 1 0       0 0   1 cobblestone lissencephaly without muscular or ocular involvement 0.8016665947624902
Q99988 GDF15 Growth/differentiation factor 15 Tier 1.5 0.718 4 75.69 1 0       1 29 41924874, 41862097, 38879214, 38477735, 37982669, 36927042, 36638554, 36508319, 36333824, 35762561, 33334063, 32527800, 31988066, 29992704, 39884764, 38497478, 38296402, 37162508, 32739349, 30335547 1 hyperemesis gravidarum 0.5821658682742563
Q9NR82 KCNQ5 Potassium voltage-gated channel subfamily KQT member 5 Tier 1.5 0.711 5 56.41 1 0       0 0   1 intellectual disability, autosomal dominant 46 0.7086662845211597
P14770 GP9 Platelet glycoprotein IX Tier 1.5 0.702 2 84.69 1 0       0 0   1 Bernard-Soulier syndrome 0.8233582238860002
P07225 PROS1 Vitamin K-dependent protein S Tier 1.5 0.7 3 82.94 1 0       1 2 36859809, 33674695 1 thrombophilia due to protein S deficiency, autosomal dominant 0.8240418292042652
P21359 NF1 Neurofibromin Tier 1.5 0.695 26 87.19 1 0       1 2 32980430, 22617876 1 neurofibromatosis type 1 0.8844735398780649
P01825 IGHV4-59 Immunoglobulin heavy variable 4-59 Tier 1.5 0.69 3 91.56 1 0       0 0   1 cutaneous Leishmaniasis 0.5868213846274001
Q6NT16 SLC18B1 MFS-type transporter SLC18B1 Tier 1.5 0.688 4 84.62 1 0       0 0   1 Parkinson disease 0.276931649354752
Q99250 SCN2A Sodium channel protein type 2 subunit alpha Tier 1.5 0.685 5 68.81 1 0       0 0   1 developmental and epileptic encephalopathy, 11 0.8388748085806758
Q15582 TGFBI Transforming growth factor-beta-induced protein ig-h3 Tier 1.5 0.682 10 90.25 1 0       0 0   1 lattice corneal dystrophy type I 0.8242841141270143
Q8TD43 TRPM4 Transient receptor potential cation channel subfamily M member 4 Tier 1.5 0.68 25 77.44 1 0       0 0   1 Familial progressive cardiac conduction defect 0.7868180621357534
O75935 DCTN3 Dynactin subunit 3 Tier 1.5 0.68 1 88.38 1 0       0 0   1 viral disease 0.03700998752471888
P05023 ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 Tier 1.5 0.679 10 88.69 1 0       0 0   1 Charcot-Marie-tooth disease, axonal, type 2DD 0.7868851290226483
Q92536 SLC7A6 Y+L amino acid transporter 2 Tier 1.5 0.678 2 83.19 1 0       0 0   1 Abnormality of the skeletal system 0.48544421359843914
P18564 ITGB6 Integrin beta-6 Tier 1.5 0.675 14 82.88 1 0       0 0   1 Hypoplastic amelogenesis imperfecta 0.6045342804405103
P36021 SLC16A2 Monocarboxylate transporter 8 Tier 1.5 0.675 7 79.56 1 0       0 0   1 Allan-Herndon-Dudley syndrome 0.8533069932022032
P32241 VIPR1 Vasoactive intestinal polypeptide receptor 1 Tier 1.5 0.667 17 76.0 1 0       0 0   1 diverticular disease 0.2747596866638145
O95563 MPC2 Mitochondrial pyruvate carrier 2 Tier 1.5 0.665 17 89.44 1 0       0 0   1 mitochondrial pyruvate carrier deficiency 0.18534429712437792
O15554 KCNN4 Intermediate conductance calcium-activated potassium channel protein 4 Tier 1.5 0.661 17 84.19 1 0       0 0   1 dehydrated hereditary stomatocytosis 0.7145864899974032
P98155 VLDLR Very low-density lipoprotein receptor Tier 1.5 0.66 27 75.69 1 0       1 1 19188685 1 Dysequilibrium syndrome 0.790164037509625
P13637 ATP1A3 Sodium/potassium-transporting ATPase subunit alpha-3 Tier 1.5 0.654 5 88.81 1 0       0 0   1 alternating hemiplegia of childhood 2 0.842328126568451
Q14524 SCN5A Sodium channel protein type 5 subunit alpha Tier 1.5 0.654 16 67.25 1 0       0 0   1 long QT syndrome 3 0.8448298602976083
P16234 PDGFRA Platelet-derived growth factor receptor alpha Tier 1.5 0.652 14 72.69 1 0       1 4 33334063, 32127469, 28010895, 30594071 1 gastrointestinal stromal tumor 0.8167494524079806
O60449 LY75 Lymphocyte antigen 75 Tier 1.5 0.65 4 75.62 1 0       0 0   1 Abruptio Placentae 0.31953367678705413
O00468 AGRN Agrin Tier 1.5 0.649 1 68.81 1 0       0 0   1 congenital myasthenic syndrome 8 0.7912009864338403
Q15027 ACAP1 Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 Tier 1.5 0.649 7 84.38 1 0       0 0   1 hypothyroidism 0.4891091360736571
O00478 BTN3A3 Butyrophilin subfamily 3 member A3 Tier 1.5 0.648 9 82.81 1 0       0 0   1 neoplasm 0.07870866954589865
P07237 P4HB Protein disulfide-isomerase Tier 1.5 0.644 14 88.5 1 0       1 2 31625090, 28952381 1 Cole-Carpenter syndrome 0.7447295842045853
Q8TEM1 NUP210 Nuclear pore membrane glycoprotein 210 Tier 1.5 0.644 2 79.56 1 0       0 0   1 HIV infection 0.5409211817593593
Q9Y4R8 TELO2 Telomere length regulation protein TEL2 homolog Tier 1.5 0.64 3 83.88 1 0       0 0   1 TELO2-related intellectual disability-neurodevelopmental disorder 0.7971337980726797
O60443 GSDME Gasdermin-E Tier 1.5 0.638 2 77.44 1 0       0 0   1 autosomal dominant nonsyndromic hearing loss 0.6288670542083885
P00846 MT-ATP6 ATP synthase F(0) complex subunit a Tier 1.5 0.636 10 88.94 1 0       0 0   1 NARP syndrome 0.760749518172638
P21731 TBXA2R Thromboxane A2 receptor Tier 1.5 0.634 6 86.25 1 0       0 0   1 bleeding diathesis due to thromboxane synthesis deficiency 0.639967145559869
O75976 CPD Carboxypeptidase D Tier 1.5 0.625 3 82.5 1 0       1 1 36457699 1 neurodegenerative disease 0.34777406871587735

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CREATE VIEW v_targets AS
SELECT f.id, n.gene_symbol, n.protein_name, tg.tier, f.priority_score,
 f.pdb_count_total, f.alphafold_mean_pLDDT, f.has_cryoEM,
 f.has_activation_state_pdb_pair, f.activation_state_pdb_active, f.activation_state_pdb_inactive,
 f.drug_count_approved, f.has_known_aptamer, f.aptamer_count_pubmed, ap.aptamer_pmids,
 f.in_cev_map, f.opentargets_top_disease_name, f.opentargets_top_disease_score
FROM v_target_full f
LEFT JOIN target_names n ON n.target_id=f.id
LEFT JOIN targets tg ON tg.id=f.id
LEFT JOIN target_aptamer_pmids ap ON ap.target_id=f.id;