Targets — browse / sort / filter (view)

One row per human protein target with names + key evidence. Click column headers to SORT; use the facets to FILTER (tier, activation pair, known aptamer, EV-Map). UniProt IDs link to the source.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

id
UniProt accession (human). Links to uniprot.org.
gene_symbol
Gene symbol (e.g. ITGB3).
protein_name
Protein name (UniProt).
tier
Tier 1 = PDB-anchored; Tier 1.5 = AlphaFold-confident.
priority_score
Composite prioritisation = 0.30*biology + 0.30*reagent-gap + 0.20*druggability + 0.10*disease + 0.10*novelty. Sub-scores are assigned during LLM-assisted curation — a heuristic ranking, NOT an experimental measurement.
has_activation_state_pdb_pair
1 if a curated ACTIVE/INACTIVE PDB pair exists (only 11 targets).
in_cev_map
1 if in the EV-Map circulating-EV proteome (Rai 2025); 3,422 targets.
has_known_aptamer
1 if aptamer evidence found in PubMed/Aptagen (1,472 targets).
opentargets_top_disease_score
Open Targets association score (0-1).
aptamer_count_pubmed
Number of PubMed hits for this protein AND (aptamer OR SELEX).
aptamer_pmids
The actual PubMed IDs behind the aptamer evidence — click each to read the paper. This is the source of the 'has aptamer' claim.

5,725 rows where has_known_aptamer = 0 sorted by priority_score descending

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tier 3

in_cev_map 2

  • 0 3,147
  • 1 2,578

has_cryoEM 2

  • 0 4,470
  • 1 1,255

has_activation_state_pdb_pair 2

  • 0 5,723
  • 1 2

has_known_aptamer 1

  • - · 5,725 ✖
id gene_symbol protein_name tier priority_score ▲ pdb_count_total alphafold_mean_pLDDT has_cryoEM has_activation_state_pdb_pair activation_state_pdb_active activation_state_pdb_inactive drug_count_approved has_known_aptamer aptamer_count_pubmed aptamer_pmids in_cev_map opentargets_top_disease_name opentargets_top_disease_score
P12263     Tier 1 0.9 7 63.59 1 0       0 0   0    
Q12879 GRIN2A Glutamate receptor ionotropic, NMDA 2A Tier 1 0.88 37 60.84 1 0       0 0   0 Landau-Kleffner syndrome 0.8407159711916629
Q9Y2C5 SLC17A4 Probable small intestine urate exporter Tier 1.5 0.878 0 83.69 0 0       0 0   0 inflammatory bowel disease 0.09896486250497885
Q9UJA9 ENPP5 Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 Tier 1 0.87 1 88.12 0 0       0 0   0 neurodegenerative disease 0.33211724272317855
Q9NX14 NDUFB11 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial Tier 1.5 0.86 0 77.56 0 0       0 0   1 Microphthalmia with linear skin defects syndrome 0.7364493324598024
Q02094 RHAG Ammonium transporter Rh type A Tier 1.5 0.841 8 95.62 1 0       0 0   1 Rh deficiency syndrome 0.764209214915708
P35346 SSTR5 Somatostatin receptor type 5 Tier 1.5 0.841 7 81.25 1 0       0 0   0 acromegaly 0.6094707180356006
P01911 HLA-DRB1 HLA class II histocompatibility antigen, DRB1 beta chain Tier 1 0.84 100 88.44 0 0       0 0   1 rheumatoid arthritis 0.40051584219092445
Q5T848 GPR158 Metabotropic glycine receptor Tier 1 0.839 6 58.03 1 0       0 0   0 diverticular disease 0.4384404783771627
Q14392 LRRC32 Transforming growth factor beta activator LRRC32 Tier 1.5 0.838 6 86.06 1 0       0 0   1 cleft palate, proliferative retinopathy, and developmental delay 0.5770707112957068
P21439 ABCB4 Phosphatidylcholine translocator ABCB4 Tier 1.5 0.835 4 83.25 1 0       0 0   0 progressive familial intrahepatic cholestasis type 3 0.851728159166962
P0DSE2 TRB M1-specific T cell receptor beta chain Tier 1 0.83 5 90.12 1 0       0 0   0    
Q31135 H2-Ab1   Tier 1 0.83 12 85.12 0 0       0 0   0    
P12532 CKMT1A Creatine kinase U-type, mitochondrial Tier 1.5 0.83 9 89.31 1 0       0 0   1 neurodegenerative disease 0.5385822922582763
O75899 GABBR2 Gamma-aminobutyric acid type B receptor subunit 2 Tier 1.5 0.824 26 77.75 1 0       0 0   0 developmental and epileptic encephalopathy, 59 0.7356789732167734
P54709 ATP1B3 Sodium/potassium-transporting ATPase subunit beta-3 Tier 1.5 0.81 7 89.69 1 0       0 0   1 congestive heart failure 0.5999952111132625
P43005 SLC1A1 Excitatory amino acid transporter 3 Tier 1 0.805 22 80.12 1 0       0 0   1 dicarboxylic aminoaciduria 0.6273449709512636
P0DPK4 NOTCH2NLC Notch homolog 2 N-terminal-like protein C Tier 1.5 0.805 0 80.81 0 0       0 0   0 neuronal intranuclear inclusion disease 0.4999829066911242
Q9NS82 SLC7A10 Asc-type amino acid transporter 1 Tier 1 0.803 4 83.38 1 0       0 0   0 asthma 0.5295411410172121
O60895 RAMP2 Receptor activity-modifying protein 2 Tier 1 0.802 10 80.94 1 0       0 0   0 diabetes mellitus 0.4219370007650345
Q04844 CHRNE Acetylcholine receptor subunit epsilon Tier 1.5 0.802 13 80.69 1 0       0 0   0 Congenital myasthenic syndromes 0.8223287249629152
P29275 ADORA2B Adenosine receptor A2b Tier 1.5 0.801 4 88.12 1 0       0 0   0 migraine disorder 0.6060142180667235
Q9H2X9 SLC12A5 Solute carrier family 12 member 5 Tier 1.5 0.8 2 78.44 1 0       0 0   0 genetic developmental and epileptic encephalopathy 0.6993945840545625
P00488 F13A1 Coagulation factor XIII A chain Tier 1 0.799 15 90.88 1 0       0 0   1 Factor XIII subunit A deficiency 0.7939842013132387
P06731 CEACAM5 Cell adhesion molecule CEACAM5 Tier 1 0.795 6 87.12 1 0       0 0   1 neurodegenerative disease 0.45156128674958135
Q9UBT7 CTNNAL1 Alpha-catulin Tier 1.5 0.795 0 84.06 0 0       0 0   1 Abnormality of the skeletal system 0.31316995706583495
P01909 HLA-DQA1 HLA class II histocompatibility antigen, DQ alpha 1 chain Tier 1 0.792 27 87.94 1 0       0 0   0 Pleural Mesothelioma 0.1228600330569846
Q13705 ACVR2B Activin receptor type-2B Tier 1.5 0.791 9 83.31 1 0       0 0   0 Heterotaxia 0.7109733260300651
Q14031 COL4A6 Collagen alpha-6(IV) chain Tier 1.5 0.79 0 47.41 0 0       0 0   0 Dupuytren Contracture 0.5880367459451578
Q96CS2 HAUS1 HAUS augmin-like complex subunit 1 Tier 1.5 0.79 1 88.62 1 0       0 0   0 device complication 0.27547205131467467
Q5JUK3 KCNT1 Potassium channel subfamily T member 1 Tier 1.5 0.782 6 73.88 1 0       0 0   0 developmental and epileptic encephalopathy, 14 0.8165232785825526
Q13639     Tier 1 0.781 3 80.88 1 0       0 0   0 schizophrenia 0.6060830827022777
P35555 FBN1 Fibrillin-1 Tier 1 0.78 11   0 0       0 0   1 Marfan syndrome 0.8969300970597663
P37023 ACVRL1 Activin receptor type-1-like Tier 1.5 0.779 7 82.0 0 0       0 0   0 telangiectasia, hereditary hemorrhagic, type 2 0.7951167515831324
P13866 SLC5A1 Sodium/glucose cotransporter 1 Tier 1.5 0.777 4 84.38 1 0       0 0   0 glucose-galactose malabsorption 0.8220991027793896
P30542 ADORA1 Adenosine receptor A1 Tier 1.5 0.777 5 92.44 1 0       0 0   0 asthma 0.7232344154541454
P01568 IFNA21 Interferon alpha-21 Tier 1.5 0.777 0 85.0 0 0       0 0   0 renal cell carcinoma 0.3695798546847018
O15393     Tier 1 0.775 31 79.38 1 0       0 0   0 COVID-19 0.6157541390484623
A6ND01 IZUMO1R Sperm-egg fusion protein Juno Tier 1 0.773 7 87.38 0 0       0 0   0 placental retention 0.23306495563589497
P02671 FGA Fibrinogen alpha chain Tier 1 0.77 40 60.34 0 0       0 0   1 familial dysfibrinogenemia 0.7947496460990987
P03951 F11 Coagulation factor XI Tier 1 0.77 100 86.88 0 0       0 0   1 factor XI deficiency 0.841884208404384
A0A5H2UYS3 HLA-A   Tier 1 0.77 20 85.25 0 0       0 0   0    
P29017 CD1C T-cell surface glycoprotein CD1c Tier 1.5 0.77 10 88.56 0 0       0 0   0 neoplasm 0.1106047389635713
Q9BVX2 TMEM106C Transmembrane protein 106C Tier 1.5 0.77 0 80.81 0 0       0 0   0 prostate carcinoma 0.21737104399686757
P29460 IL12B Interleukin-12 subunit beta Tier 1 0.769 20 91.12 1 0       0 0   0 psoriasis 0.7914863943708039
P27037 ACVR2A Activin receptor type-2A Tier 1.5 0.769 5 83.56 0 0       0 0   1 hepatocellular carcinoma 0.4908023126074436
P43004 SLC1A2 Excitatory amino acid transporter 2 Tier 1.5 0.768 7 77.75 1 0       0 0   0 developmental and epileptic encephalopathy, 41 0.7772658651722512
O14958 CASQ2 Calsequestrin-2 Tier 1.5 0.767 4 90.5 0 0       0 0   1 catecholaminergic polymorphic ventricular tachycardia 0.7718998507471558
Q9H3K6 BOLA2 BolA-like protein 2 Tier 1.5 0.765 0 92.69 0 0       0 0   1 hepatocellular carcinoma 0.08093942543094014
A0A1B0GTW7 CIROP Ciliated left-right organizer metallopeptidase Tier 1.5 0.764 0 73.44 0 0       0 0   0 heterotaxy, visceral, 12, autosomal 0.6929422132808513

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CREATE VIEW v_targets AS
SELECT f.id, n.gene_symbol, n.protein_name, tg.tier, f.priority_score,
 f.pdb_count_total, f.alphafold_mean_pLDDT, f.has_cryoEM,
 f.has_activation_state_pdb_pair, f.activation_state_pdb_active, f.activation_state_pdb_inactive,
 f.drug_count_approved, f.has_known_aptamer, f.aptamer_count_pubmed, ap.aptamer_pmids,
 f.in_cev_map, f.opentargets_top_disease_name, f.opentargets_top_disease_score
FROM v_target_full f
LEFT JOIN target_names n ON n.target_id=f.id
LEFT JOIN targets tg ON tg.id=f.id
LEFT JOIN target_aptamer_pmids ap ON ap.target_id=f.id;