Targets — browse / sort / filter (view)

One row per human protein target with names + key evidence. Click column headers to SORT; use the facets to FILTER (tier, activation pair, known aptamer, EV-Map). UniProt IDs link to the source.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

id
UniProt accession (human). Links to uniprot.org.
gene_symbol
Gene symbol (e.g. ITGB3).
protein_name
Protein name (UniProt).
tier
Tier 1 = PDB-anchored; Tier 1.5 = AlphaFold-confident.
priority_score
Composite prioritisation = 0.30*biology + 0.30*reagent-gap + 0.20*druggability + 0.10*disease + 0.10*novelty. Sub-scores are assigned during LLM-assisted curation — a heuristic ranking, NOT an experimental measurement.
has_activation_state_pdb_pair
1 if a curated ACTIVE/INACTIVE PDB pair exists (only 11 targets).
in_cev_map
1 if in the EV-Map circulating-EV proteome (Rai 2025); 3,422 targets.
has_known_aptamer
1 if aptamer evidence found in PubMed/Aptagen (1,472 targets).
opentargets_top_disease_score
Open Targets association score (0-1).
aptamer_count_pubmed
Number of PubMed hits for this protein AND (aptamer OR SELEX).
aptamer_pmids
The actual PubMed IDs behind the aptamer evidence — click each to read the paper. This is the source of the 'has aptamer' claim.

1,060 rows where has_known_aptamer = 0, in_cev_map = 0 and tier = "Tier 1" sorted by priority_score descending

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has_cryoEM 2

  • 0 663
  • 1 397

tier 1

  • Tier 1 · 1,060 ✖

in_cev_map 1

  • - · 1,060 ✖

has_known_aptamer 1

  • - · 1,060 ✖

has_activation_state_pdb_pair 1

  • 0 1,060
id gene_symbol protein_name tier priority_score ▲ pdb_count_total alphafold_mean_pLDDT has_cryoEM has_activation_state_pdb_pair activation_state_pdb_active activation_state_pdb_inactive drug_count_approved has_known_aptamer aptamer_count_pubmed aptamer_pmids in_cev_map opentargets_top_disease_name opentargets_top_disease_score
P12263     Tier 1 0.9 7 63.59 1 0       0 0   0    
Q12879 GRIN2A Glutamate receptor ionotropic, NMDA 2A Tier 1 0.88 37 60.84 1 0       0 0   0 Landau-Kleffner syndrome 0.8407159711916629
Q9UJA9 ENPP5 Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 Tier 1 0.87 1 88.12 0 0       0 0   0 neurodegenerative disease 0.33211724272317855
Q5T848 GPR158 Metabotropic glycine receptor Tier 1 0.839 6 58.03 1 0       0 0   0 diverticular disease 0.4384404783771627
P0DSE2 TRB M1-specific T cell receptor beta chain Tier 1 0.83 5 90.12 1 0       0 0   0    
Q31135 H2-Ab1   Tier 1 0.83 12 85.12 0 0       0 0   0    
Q9NS82 SLC7A10 Asc-type amino acid transporter 1 Tier 1 0.803 4 83.38 1 0       0 0   0 asthma 0.5295411410172121
O60895 RAMP2 Receptor activity-modifying protein 2 Tier 1 0.802 10 80.94 1 0       0 0   0 diabetes mellitus 0.4219370007650345
P01909 HLA-DQA1 HLA class II histocompatibility antigen, DQ alpha 1 chain Tier 1 0.792 27 87.94 1 0       0 0   0 Pleural Mesothelioma 0.1228600330569846
Q13639     Tier 1 0.781 3 80.88 1 0       0 0   0 schizophrenia 0.6060830827022777
O15393     Tier 1 0.775 31 79.38 1 0       0 0   0 COVID-19 0.6157541390484623
A6ND01 IZUMO1R Sperm-egg fusion protein Juno Tier 1 0.773 7 87.38 0 0       0 0   0 placental retention 0.23306495563589497
A0A5H2UYS3 HLA-A   Tier 1 0.77 20 85.25 0 0       0 0   0    
P29460 IL12B Interleukin-12 subunit beta Tier 1 0.769 20 91.12 1 0       0 0   0 psoriasis 0.7914863943708039
P98073     Tier 1 0.761 14 81.5 1 0       0 0   0 congenital enteropathy due to enteropeptidase deficiency 0.7102613227574134
O75762 TRPA1 Transient receptor potential cation channel subfamily A member 1 Tier 1 0.76 17 81.94 1 0       0 0   0 familial episodic pain syndrome with predominantly upper body involvement 0.6615353934604322
O43614     Tier 1 0.75 11 78.94 1 0       0 0   0 insomnia 0.5988748728311054
P16471 PRLR Prolactin receptor Tier 1 0.747 12 61.03 0 0       0 0   0 familial hyperprolactinemia 0.5718636087471152
P01563     Tier 1 0.744 13 85.06 0 0       0 0   0 renal cell carcinoma 0.3938654263610389
O15245 SLC22A1 Solute carrier family 22 member 1 Tier 1 0.744 16 84.25 1 0       0 0   0 coronary artery disease 0.5384890077265535
Q8N158 GPC2 Glypican-2 Tier 1 0.744 2 79.06 1 0       0 0   0 COVID-19 0.5409211817593593
O43526 KCNQ2 Potassium voltage-gated channel subfamily KQT member 2 Tier 1 0.744 24 58.19 1 0       0 0   0 Benign familial neonatal seizures 0.8423358217314708
P40879 SLC26A3 Chloride anion exchanger Tier 1 0.742 13 85.06 1 0       0 0   0 congenital secretory chloride diarrhea 1 0.8189631913308207
D7RIG0 HLA-DRB1   Tier 1 0.74 10 84.94 1 0       0 0   0    
A0A1B0GX56 TRDV1 T cell receptor delta variable 1 Tier 1 0.737 7 90.69 1 0       0 0   0 colorectal carcinoma 0.07391597093694036
Q14028 CNGB1 Cyclic nucleotide-gated channel beta-1 Tier 1 0.734 11 57.66 1 0       0 0   0 retinitis pigmentosa 0.7931901344765326
P41145 OPRK1 Kappa-type opioid receptor Tier 1 0.725 28 79.5 1 0       0 0   0 alcohol dependence 0.6106562988740131
P23416 GLRA2 Glycine receptor subunit alpha-2 Tier 1 0.723 13 83.81 1 0       0 0   0 intellectual developmental disorder, X-linked, syndromic, Pilorge type 0.7805605973560554
Q16878 CDO1 Cysteine dioxygenase type 1 Tier 1 0.72 17 93.62 0 0       0 0   0 adolescent idiopathic scoliosis 0.3105991982786747
P29033 GJB2 Gap junction beta-2 protein Tier 1 0.72 24 86.19 1 0       0 0   0 palmoplantar keratoderma-deafness syndrome 0.8149616697051898
B7Z8K6 TRDC T cell receptor delta constant Tier 1 0.72 12 81.38 1 0       0 0   0    
Q12918 KLRB1 Killer cell lectin-like receptor subfamily B member 1 Tier 1 0.719 3 81.0 0 0       0 0   0 sensory perception of smell 0.287724180593876
A0A0B4J271 TRAV12-3 T cell receptor alpha variable 12-3 Tier 1 0.715 12 92.56 1 0       0 0   0 ulcerative colitis 0.003139210371371825
Q695T7 SLC6A19 Sodium-dependent neutral amino acid transporter B(0)AT1 Tier 1 0.715 19 90.0 1 0       0 0   0 Hartnup disease 0.8464240093600148
Q99574 SERPINI1 Neuroserpin Tier 1 0.712 3 88.12 0 0       0 0   0 familial encephalopathy with neuroserpin inclusion bodies 0.7162803151916303
A0A583ZB34     Tier 1 0.71 9 84.38 0 0       0 0   0    
P49019 HCAR3 Hydroxycarboxylic acid receptor 3 Tier 1 0.709 11 79.19 1 0       0 0   0 Oral ulcer 0.3943093179045574
O15342 ATP6V0E1 V-type proton ATPase subunit e 1 Tier 1 0.708 9 92.88 1 0       0 0   0 multiple myeloma 0.18220286553988743
Q9BXJ8 TMEM120A Transmembrane protein 120A Tier 1 0.706 5 89.25 1 0       0 0   0 congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency 0.1609725589293368
P14555 PLA2G2A Phospholipase A2, membrane associated Tier 1 0.7 17 91.0 0 0       0 0   0 familial colorectal cancer 0.3326218692162316
Q5Y7D3 HLA-DQB1   Tier 1 0.7 6 85.31 0 0       0 0   0    
P22888 LHCGR Lutropin-choriogonadotropic hormone receptor Tier 1 0.698 4 80.12 1 0       0 0   0 Leydig cell hypoplasia, type 1 0.783461117057047
O43570 CA12 Carbonic anhydrase 12 Tier 1 0.695 40 87.81 0 0       0 0   0 isolated hyperchlorhidrosis 0.6794515382695604
Q07699 SCN1B Sodium channel regulatory subunit beta-1 Tier 1 0.695 36 87.06 1 0       0 0   0 Generalized epilepsy with febrile seizures-plus 0.7638796221342504
P30989 NTSR1 Neurotensin receptor type 1 Tier 1 0.695 24 79.62 1 0       0 0   0 Cough 0.31206841983343936
Q96QV1 HHIP Hedgehog-interacting protein Tier 1 0.692 11 79.75 0 0       0 0   0 Abnormality of the skeletal system 0.5195282784554633
P04435 TRBV7-9 T cell receptor beta variable 7-9 Tier 1 0.691 2 90.06 0 0       0 0   0 neoplasm 0.11454334012562349
Q02083 NAAA N-acylethanolamine-hydrolyzing acid amidase Tier 1 0.69 2 92.25 0 0       0 0   0 abscess 0.2726858643799341
Q15788 NCOA1 Nuclear receptor coactivator 1 Tier 1 0.69 100 46.72 0 0       0 0   0 neurodegenerative disease 0.48697450901885614
A0A9P1NJI6     Tier 1 0.69 6   0 0       0 0   0    

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CREATE VIEW v_targets AS
SELECT f.id, n.gene_symbol, n.protein_name, tg.tier, f.priority_score,
 f.pdb_count_total, f.alphafold_mean_pLDDT, f.has_cryoEM,
 f.has_activation_state_pdb_pair, f.activation_state_pdb_active, f.activation_state_pdb_inactive,
 f.drug_count_approved, f.has_known_aptamer, f.aptamer_count_pubmed, ap.aptamer_pmids,
 f.in_cev_map, f.opentargets_top_disease_name, f.opentargets_top_disease_score
FROM v_target_full f
LEFT JOIN target_names n ON n.target_id=f.id
LEFT JOIN targets tg ON tg.id=f.id
LEFT JOIN target_aptamer_pmids ap ON ap.target_id=f.id;