Targets — browse / sort / filter (view)

One row per human protein target with names + key evidence. Click column headers to SORT; use the facets to FILTER (tier, activation pair, known aptamer, EV-Map). UniProt IDs link to the source.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

id
UniProt accession (human). Links to uniprot.org.
gene_symbol
Gene symbol (e.g. ITGB3).
protein_name
Protein name (UniProt).
tier
Tier 1 = PDB-anchored; Tier 1.5 = AlphaFold-confident.
priority_score
Composite prioritisation = 0.30*biology + 0.30*reagent-gap + 0.20*druggability + 0.10*disease + 0.10*novelty. Sub-scores are assigned during LLM-assisted curation — a heuristic ranking, NOT an experimental measurement.
has_activation_state_pdb_pair
1 if a curated ACTIVE/INACTIVE PDB pair exists (only 11 targets).
in_cev_map
1 if in the EV-Map circulating-EV proteome (Rai 2025); 3,422 targets.
has_known_aptamer
1 if aptamer evidence found in PubMed/Aptagen (1,472 targets).
opentargets_top_disease_score
Open Targets association score (0-1).
aptamer_count_pubmed
Number of PubMed hits for this protein AND (aptamer OR SELEX).
aptamer_pmids
The actual PubMed IDs behind the aptamer evidence — click each to read the paper. This is the source of the 'has aptamer' claim.

1,278 rows where has_known_aptamer = 0, in_cev_map = 1 and tier = "Tier 1" sorted by priority_score descending

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has_cryoEM 2

  • 0 830
  • 1 448

has_activation_state_pdb_pair 2

  • 0 1,277
  • 1 1

tier 1

  • Tier 1 · 1,278 ✖

in_cev_map 1

  • 1 · 1,278 ✖

has_known_aptamer 1

  • - · 1,278 ✖
id gene_symbol protein_name tier priority_score ▲ pdb_count_total alphafold_mean_pLDDT has_cryoEM has_activation_state_pdb_pair activation_state_pdb_active activation_state_pdb_inactive drug_count_approved has_known_aptamer aptamer_count_pubmed aptamer_pmids in_cev_map opentargets_top_disease_name opentargets_top_disease_score
P01911 HLA-DRB1 HLA class II histocompatibility antigen, DRB1 beta chain Tier 1 0.84 100 88.44 0 0       0 0   1 rheumatoid arthritis 0.40051584219092445
P43005 SLC1A1 Excitatory amino acid transporter 3 Tier 1 0.805 22 80.12 1 0       0 0   1 dicarboxylic aminoaciduria 0.6273449709512636
P00488 F13A1 Coagulation factor XIII A chain Tier 1 0.799 15 90.88 1 0       0 0   1 Factor XIII subunit A deficiency 0.7939842013132387
P06731 CEACAM5 Cell adhesion molecule CEACAM5 Tier 1 0.795 6 87.12 1 0       0 0   1 neurodegenerative disease 0.45156128674958135
P35555 FBN1 Fibrillin-1 Tier 1 0.78 11   0 0       0 0   1 Marfan syndrome 0.8969300970597663
P02671 FGA Fibrinogen alpha chain Tier 1 0.77 40 60.34 0 0       0 0   1 familial dysfibrinogenemia 0.7947496460990987
P03951 F11 Coagulation factor XI Tier 1 0.77 100 86.88 0 0       0 0   1 factor XI deficiency 0.841884208404384
P02747 C1QC Complement C1q subcomponent subunit C Tier 1 0.762 11 80.56 1 0       0 0   1 C1Q deficiency 0.6233532074390745
Q02817 MUC2 Mucin-2 Tier 1 0.76 12   1 0       0 0   1    
P07360     Tier 1 0.755 15 89.75 1 0       0 0   1 complement deficiency 0.3695798546847018
P55899 FCGRT IgG receptor FcRn large subunit p51 Tier 1 0.752 31 85.0 1 0       0 0   1 Myasthenia gravis 0.5932721106551206
Q9BY67 CADM1 Cell adhesion molecule 1 Tier 1 0.734 2 80.56 0 0       0 0   1 Abnormality of the skeletal system 0.442731358018962
Q99497 PARK7 Parkinson disease protein 7 Tier 1 0.723 88 98.44 0 0       0 0   1 Young adult-onset Parkinsonism 0.7264878745993893
P11215 ITGAM Integrin alpha-M Tier 1 0.72 30 86.25 1 0       0 0   1 systemic lupus erythematosus 0.30502849242596436
Q9NV96 TMEM30A Cell cycle control protein 50A Tier 1 0.71 33 89.5 1 0       0 0   1 atrial fibrillation 0.31177132249681394
P01889 HLA-B HLA class I histocompatibility antigen, B alpha chain Tier 1 0.708 100 88.06 0 0       0 0   1 COVID-19 0.48417012135481613
O60486 PLXNC1 Plexin-C1 Tier 1 0.703 4 79.06 1 0       0 0   1 asthma 0.532656225351722
P08473 MME Neprilysin Tier 1 0.699 16 96.19 0 0       0 0   1 Charcot-Marie-Tooth disease axonal type 2T 0.7912653398252156
Q92187 ST8SIA4 CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase Tier 1 0.69 3 86.44 0 0       0 0   1 systemic lupus erythematosus 0.43832763677821385
Q8NBJ9     Tier 1 0.688 7 80.25 1 0       0 0   1 hypothyroidism 0.32686531914177924
O95399 UTS2 Urotensin-2 Tier 1 0.685 2 58.44 0 0       0 0   1 hair color 0.35316475479030335
P63092 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Tier 1 0.683 100 91.31 1 0       0 0   1 pseudohypoparathyroidism type 1A 0.826829760867455
Q14213     Tier 1 0.683 4 87.62 1 0       0 0   1 neurodegenerative disease 0.42776938116451996
Q99584 S100A13 Protein S100-A13 Tier 1 0.681 12 80.81 0 0       0 0   1 neurodegenerative disease 0.41302685279153983
Q9UNN8 PROCR Endothelial protein C receptor Tier 1 0.68 13 86.44 1 0       0 0   1 venous thromboembolism 0.5497662282245215
Q9HBI1 PARVB Beta-parvin Tier 1 0.68 3 81.75 0 0       0 0   1 thyroiditis 0.28021156500366357
O00602 FCN1 Ficolin-1 Tier 1 0.675 7 84.94 0 0       0 0   1 neurodegenerative disease 0.351581018821974
Q9UK55 SERPINA10 Protein Z-dependent protease inhibitor Tier 1 0.672 4 86.75 0 0       0 0   1 macular degeneration 0.3247169581531489
P02749 APOH Beta-2-glycoprotein 1 Tier 1 0.67 14 93.12 0 0       0 0   1 atrial fibrillation 0.5456247991985232
P06703 S100A6 Protein S100-A6 Tier 1 0.67 6 87.19 0 0       0 0   1 neoplasm 0.10449825238323361
P78552 IL13RA1 Interleukin-13 receptor subunit alpha-1 Tier 1 0.67 4 81.56 0 0       0 0   1 type 2 diabetes mellitus 0.48627783096767857
P54762 EPHB1 Ephrin type-B receptor 1 Tier 1 0.665 8 83.62 0 0       0 0   1 medullary thyroid gland carcinoma 0.5204553830376101
Q14344 GNA13 Guanine nucleotide-binding protein subunit alpha-13 Tier 1 0.66 17 91.44 1 0       0 0   1 lymphoma 0.37253457492562664
Q7L2H7 EIF3M Eukaryotic translation initiation factor 3 subunit M Tier 1 0.66 0 55.28 0 0       0 0   1 Hernia 0.2963310523049043
P05543 SERPINA7 Thyroxine-binding globulin Tier 1 0.655 9 87.06 0 0       0 0   1 neoplasm 0.09631257418600654
P20701 ITGAL Integrin alpha-L Tier 1 0.655 41 82.62 0 0       0 0   1 psoriasis 0.5899795223699872
Q5JWF2 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas Tier 1 0.653 9 56.72 1 0       0 0   1 pseudohypoparathyroidism type 1A 0.826829760867455
P54764     Tier 1 0.652 17 83.5 0 0       0 0   1 medullary thyroid gland carcinoma 0.5195314334008982
P04746 AMY2A Pancreatic alpha-amylase Tier 1 0.65 51 96.75 0 0       0 0   1 type 2 diabetes mellitus 0.5997984923419163
Q13936 CACNA1C Voltage-dependent L-type calcium channel subunit alpha-1C Tier 1 0.65 33 61.94 1 0       0 0   1 Timothy syndrome 0.8227725490420764
P62491 RAB11A Ras-related protein Rab-11A Tier 1 0.64 30 87.19 0 0       0 0   1 Intellectual disability 0.4852051194358318
P26447 S100A4 Protein S100-A4 Tier 1 0.636 17 86.44 0 0       0 0   1 Alzheimer disease 0.36416197951415524
P54289 CACNA2D1 Voltage-dependent calcium channel subunit alpha-2/delta-1 Tier 1 0.635 30 86.56 1 0       0 0   1 Seizure 0.6942469435259896
P20963 CD247 T-cell surface glycoprotein CD3 zeta chain Tier 1 0.635 38 62.41 1 0       0 0   1 immunodeficiency 25 0.7436838111879828
Q96A54 ADIPOR1 Adiponectin receptor protein 1 Tier 1 0.632 3 83.25 0 0       0 0   1 Retinal dystrophy 0.17324768030468937
Q16555 DPYSL2 Dihydropyrimidinase-related protein 2 Tier 1 0.63 15 90.25 1 0       0 0   1 hypertension 0.4377422749119531
O14939 PLD2 Phospholipase D2 Tier 1 0.63 6 88.94 0 0       0 0   1 systemic lupus erythematosus 0.22499036596471594
Q15113 PCOLCE Procollagen C-endopeptidase enhancer 1 Tier 1 0.63 4 79.56 0 0       0 0   1 hair color 0.09954732229482598
P49790 NUP153 Nuclear pore complex protein Nup153 Tier 1 0.63 12 43.59 1 0       0 0   1 HIV infection 0.5431773609684529
O75970 MPDZ Multiple PDZ domain protein Tier 1 0.628 9 63.72 0 0       0 0   1 Congenital muscular alpha-dystroglycanopathy with brain and eye anomalies 0.7761660121864681

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CREATE VIEW v_targets AS
SELECT f.id, n.gene_symbol, n.protein_name, tg.tier, f.priority_score,
 f.pdb_count_total, f.alphafold_mean_pLDDT, f.has_cryoEM,
 f.has_activation_state_pdb_pair, f.activation_state_pdb_active, f.activation_state_pdb_inactive,
 f.drug_count_approved, f.has_known_aptamer, f.aptamer_count_pubmed, ap.aptamer_pmids,
 f.in_cev_map, f.opentargets_top_disease_name, f.opentargets_top_disease_score
FROM v_target_full f
LEFT JOIN target_names n ON n.target_id=f.id
LEFT JOIN targets tg ON tg.id=f.id
LEFT JOIN target_aptamer_pmids ap ON ap.target_id=f.id;