Targets — browse / sort / filter (view)

One row per human protein target with names + key evidence. Click column headers to SORT; use the facets to FILTER (tier, activation pair, known aptamer, EV-Map). UniProt IDs link to the source.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

id
UniProt accession (human). Links to uniprot.org.
gene_symbol
Gene symbol (e.g. ITGB3).
protein_name
Protein name (UniProt).
tier
Tier 1 = PDB-anchored; Tier 1.5 = AlphaFold-confident.
priority_score
Composite prioritisation = 0.30*biology + 0.30*reagent-gap + 0.20*druggability + 0.10*disease + 0.10*novelty. Sub-scores are assigned during LLM-assisted curation — a heuristic ranking, NOT an experimental measurement.
has_activation_state_pdb_pair
1 if a curated ACTIVE/INACTIVE PDB pair exists (only 11 targets).
in_cev_map
1 if in the EV-Map circulating-EV proteome (Rai 2025); 3,422 targets.
has_known_aptamer
1 if aptamer evidence found in PubMed/Aptagen (1,472 targets).
opentargets_top_disease_score
Open Targets association score (0-1).
aptamer_count_pubmed
Number of PubMed hits for this protein AND (aptamer OR SELEX).
aptamer_pmids
The actual PubMed IDs behind the aptamer evidence — click each to read the paper. This is the source of the 'has aptamer' claim.

368 rows where has_known_aptamer = 1, in_cev_map = 0 and tier = "Tier 1" sorted by priority_score descending

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has_cryoEM 2

  • 0 243
  • 1 125

tier 1

  • Tier 1 · 368 ✖

in_cev_map 1

has_known_aptamer 1

has_activation_state_pdb_pair 1

  • 0 368
id gene_symbol protein_name tier priority_score ▲ pdb_count_total alphafold_mean_pLDDT has_cryoEM has_activation_state_pdb_pair activation_state_pdb_active activation_state_pdb_inactive drug_count_approved has_known_aptamer aptamer_count_pubmed aptamer_pmids in_cev_map opentargets_top_disease_name opentargets_top_disease_score
P23946 CMA1 Chymase Tier 1 0.875 42 91.31 0 0       1 1 30572223 0 pernicious anemia 0.17348905136256007
A0A0E3EAY4 env Envelope glycoprotein gp160 Tier 1 0.82 2   1 0       1 12 36576612, 29464116, 29217761, 22379083, 18776229, 18569791, 16146716, 16043495, 16013840, 12498773, 11024283, 9713975 0    
P35414 APLNR Apelin receptor Tier 1 0.8 37 81.69 1 0       1 1 36126144 0 essential hypertension 0.2159614840844307
P01236 PRL Prolactin Tier 1 0.795 12 85.56 0 0       1 6 40327044, 30834248, 29277631, 28263753, 27679852, 16947086 0 AL amyloidosis 0.4619748183558772
O14788 TNFSF11 Tumor necrosis factor ligand superfamily member 11 Tier 1 0.79 2 79.19 0 0       1 2 15562003, 41226313 0 osteoporosis 0.6957850224892792
P07911 UMOD Uromodulin Tier 1 0.774 10 82.94 1 0       1 4 37533140, 35446786 0 familial juvenile hyperuricemic nephropathy type 1 0.8446536377993564
P26951 IL3RA Interleukin-3 receptor subunit alpha Tier 1 0.767 4 85.25 0 0       1 3 40931580, 36171541, 31323275 0 acute myeloid leukemia 0.46904332714118013
P40225 THPO Thrombopoietin Tier 1 0.76 3 61.44 1 0       1 2 38928037, 30312735 0 thrombocythemia 1 0.7027329039559379
Q9ULV1 FZD4 Frizzled-4 Tier 1 0.745 11 84.31 1 0       1 1 18673242 0 Familial exudative vitreoretinopathy 0.8152111103672746
P21730 C5AR1 C5a anaphylatoxin chemotactic receptor 1 Tier 1 0.741 19 85.75 1 0       1 5 33495506, 29981048, 29327939, 28288993, 25901944 0 anti-neutrophil cytoplasmic antibody-associated vasculitis 0.5076734733894334
K7N5M4 B2M   Tier 1 0.72 24 90.94 0 0       1 3 41850110, 40373155, 38904251 0    
P42262 GRIA2 Glutamate receptor 2 Tier 1 0.715 16 84.94 0 0       1 4 28325839, 19417060, 17929944, 17024188 0 neurodevelopmental disorder with language impairment and behavioral abnormalities 0.8328652004757138
P20809 IL11 Interleukin-11 Tier 1 0.712 8 82.62 1 0       1 8 39408993, 39263947, 28791655, 27878687, 25696907, 24629635 0 osteoarthritis, hip 0.31754029889853136
P14207 FOLR2 Folate receptor beta Tier 1 0.701 5 89.12 0 0       1 2 28686804 0 neoplasm 0.11545394821329319
P15248 IL9 Interleukin-9 Tier 1 0.7 5 84.06 0 0       1 1 40972397 0 neurodegenerative disease 0.40148548290272756
P01374 LTA Lymphotoxin-alpha Tier 1 0.7 3 83.44 0 0       1 3 41810142, 30576605 0    
P15309 ACP3 Prostatic acid phosphatase Tier 1 0.695 17 92.25 1 0       1 3 41890985, 25591398 0 prostate cancer 0.5521391557206573
Q95460 MR1 Major histocompatibility complex class I-related protein 1 Tier 1 0.693 79 87.5 0 0       1 2 41134135, 20000526 0 Immunodeficiency 0.3336382138166145
Q9NPF0 CD320 CD320 antigen Tier 1 0.69 6 63.81 0 0       1 1 39493449 0 Methylmalonic aciduria due to transcobalamin receptor defect 0.49918945650121177
P48061 CXCL12 Stromal cell-derived factor 1 Tier 1 0.685 34 83.25 1 0       1 36 41951573, 41931849, 41907643, 41527798, 40401615, 40008515, 39865939, 39263947, 38806504, 38477735, 32784904, 31267721, 31097627, 30465210, 30385042, 29111236, 28963140, 28670693, 27940247, 27924617, 27392463, 26265085, 25560701, 25236655, 24526776, 24277076, 23615526, 22376154, 21147843, 41963275 0 HIV-1 infection 0.3675509850165065
Q6NW40 RGMB Repulsive guidance molecule B Tier 1 0.683 11 79.44 1 0       1 1 39263947 0 Abnormality of the skeletal system 0.42535629367019584
P39900 MMP12 Macrophage metalloelastase Tier 1 0.68 86 86.94 0 0       1 8 41861669, 38477735, 38296402, 37015819, 35120890, 34183667, 27530235 0 atopic eczema 0.4795677061208266
Q9UEF7 KL Klotho Tier 1 0.676 6 89.06 1 0       1 19 41978019, 41851110, 41038766, 40370992, 39975897, 39909827, 38500260, 38233588, 37584531, 36891771, 36535944, 35770801, 35360393, 34375633, 33536505, 31511614, 25325398, 18569791, 40514411 0 type 2 diabetes mellitus 0.5587488336100863
Q86Z14 KLB Beta-klotho Tier 1 0.676 5 89.38 0 0       1 1 40514411 0 congenital hypogonadotropic hypogonadism 0.462898767992589
P51681 CCR5 C-C chemokine receptor type 5 Tier 1 0.674 25 85.38 1 0       1 23 36576612, 33981364, 29678881, 29556342, 29301363, 27807347, 27652575, 26965267, 25794434, 25754473, 25329893, 23629001, 22811524, 21576818, 18799178, 16631118, 16227301, 15813986, 14610191, 12498773 0 HIV infection 0.7442590579227027
P62576 nanA Sialidase A Tier 1 0.67 5 81.19 0 0       1 4 37350189, 34976356, 34341854, 32034503 0    
Q9GZX9 TWSG1 Twisted gastrulation protein homolog 1 Tier 1 0.67 6 80.38 0 0       1 1 39299474 0 Abruptio Placentae 0.29495361755469174
P56704 WNT3A Protein Wnt-3a Tier 1 0.665 4 88.31 1 0       1 1 37231925 0 neurodegenerative disease 0.5271953966006525
P05113 IL5 Interleukin-5 Tier 1 0.664 5 86.69 1 0       1 12 40972397, 35487180, 35356877, 34831332, 32784904, 32038731, 29881374, 28062796, 26048585 0 asthma 0.6399821251487101
O15169 AXIN1 Axin-1 Tier 1 0.664 22 61.09 0 0       1 2 28129128 0 hepatocellular carcinoma 0.7864172882686208
P15941 MUC1 Mucin-1 Tier 1 0.66 23 47.41 0 0       1 686 42025056, 41988862, 41954302, 41771296, 41744704, 41744190, 41657320, 41627316, 41621292, 41582516, 41535857, 41471303, 41362016, 41352919, 41346179, 41330302, 41243570, 41205458, 41185018, 41101154, 41047832, 41027169, 40682599, 40665615, 40627939, 40607530, 40590839, 40578633, 40568899, 40556592, 40504676, 40500890, 40499867, 40479828, 40432219, 40422041, 40360093, 40286646, 40274149, 40158809, 40119836, 39978149, 39910821, 39705316, 39679901, 39626346, 39579679, 39566700, 39552005, 39550818, 41997681, 41247195, 40813258, 39454542, 39454415, 39440615, 39421884, 39406784, 39256285, 39243449, 39154820, 39142532, 39136402, 39119745, 39118454, 38923850, 38912896 0 tubulointerstitial kidney disease, autosomal dominant, 2 0.7040398435219726
Q92876 KLK6 Kallikrein-6 Tier 1 0.659 21 91.75 0 0       1 2 30114962, 22505517 0 neuroinflammatory disorder 0.1901077464611955
P22894 MMP8 Neutrophil collagenase Tier 1 0.655 25 90.38 0 0       1 4 35821507, 34183667, 33534888, 30197987 0 acne 0.603247809982021
Q12809 KCNH2 Voltage-gated inwardly rectifying potassium channel KCNH2 Tier 1 0.655 23 62.75 1 0       1 1 22617876 0 Romano-Ward syndrome 0.8549238933917284
P45452 MMP13 Collagenase 3 Tier 1 0.65 49 88.62 0 0       1 4 41754778, 40893365, 38471488, 38750696 0 spondyloepimetaphyseal dysplasia, Missouri type 0.8032079813035149
P10747 CD28 T-cell-specific surface glycoprotein CD28 Tier 1 0.641 10 81.31 0 0       1 12 40702285, 40479828, 36979667, 36126113, 32584540, 32280743, 32024070, 26999456, 26992239, 26320067, 23756353, 10435754 0 HIV infection 0.5105949023227331
Q13651 IL10RA Interleukin-10 receptor subunit alpha Tier 1 0.641 7 62.0 1 0       1 2 25870409, 25558474 0 Autosomal recessive early-onset inflammatory bowel disease 0.8151052076044897
Q04609 FOLH1 Glutamate carboxypeptidase 2 Tier 1 0.64 88 93.81 0 0       1 47 41855944, 41683470, 41548790, 41478044, 41126016, 40684732, 39388218, 39187748, 38769597, 34341883, 33794195, 33061374, 33025277, 32721116, 32611993, 32525981, 32208602, 29313393, 28794625, 28746182, 27574424, 27456457, 27228412, 27077564, 26985893, 26472453, 26438155, 25938427, 25620467, 25620167, 25473281, 24954476, 24337602, 24321253, 23590171, 21980237, 21641946, 21555850, 21147500, 20550178, 20407731, 19701187, 19514954, 19488725, 18776550, 15520166, 12124337 0 prostate cancer 0.5500818985644047
O00206 TLR4 Toll-like receptor 4 Tier 1 0.621 15 89.19 1 0       1 32 41864915, 41444487, 40521190, 39897575, 38931862, 38742374, 38280803, 37360693, 36916435, 36908619, 35410404, 35402075, 35189346, 34831332, 32784904, 29910175, 29250957, 25483705 0 major depressive disorder 0.5065500149392951
P78380 OLR1 Oxidized low-density lipoprotein receptor 1 Tier 1 0.62 13 87.44 0 0       1 1 35821507 0 head and neck squamous cell carcinoma 0.10910332327226395
O14625 CXCL11 C-X-C motif chemokine 11 Tier 1 0.62 2 79.94 1 0       1 4 36649818, 32784904, 30578658, 23935890 0 neoplasm 0.11537901464416651
Q9HBE5 IL21R Interleukin-21 receptor Tier 1 0.615 6 64.12 0 0       1 2 30800133, 29244152 0 Cryptosporidiosis - chronic cholangitis - liver disease 0.7501392499286187
O60885 BRD4 Bromodomain-containing protein 4 Tier 1 0.615 100 55.31 0 0       1 6 41824501, 41088826, 40957137, 35185589, 22609015 0 Cornelia de Lange syndrome 6 0.6842985362822729
P01887 B2m Beta-2-microglobulin Tier 1 0.61 100 93.81 0 0       1 15 41850110, 40373155, 38904251, 40658810, 35026285, 32631049, 29281176, 28960840, 25100729, 20616783, 19137104, 17878167 0    
P12643 BMP2 Bone morphogenetic protein 2 Tier 1 0.61 21 79.56 0 0       1 10 41144653, 38542880, 37231465, 35591468, 35195734, 34067593, 33997500 0 short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1 0.7361833785834584
P20062 TCN2 Transcobalamin-2 Tier 1 0.605 11 91.5 0 0       1 3 41935727, 39493449 0 transcobalamin II deficiency 0.8116989428679681
P15018 LIF Leukemia inhibitory factor Tier 1 0.605 5 87.12 1 0       1 38 41611413, 38359901, 37549567, 37175248, 36838669, 33640806, 32253765, 31791592, 31357280, 30771937, 30037541, 29289340, 28963578, 28763192, 27855943, 26877178, 26764106, 26695234, 26344338, 26113415, 25335821, 25311485, 25035238, 24716781, 22648816, 22471443, 27335672, 20673578, 20151395, 19803140, 18646283, 17315151, 16331583, 16053313, 11791582, 9823713, 39571081, 31461490 0 alcohol drinking 0.24197086949132446
P00797 REN Renin Tier 1 0.605 91 85.44 0 0       1 456 42025056, 42000159, 41992303, 41979049, 41942404, 41934998, 41909751, 41904852, 41851110, 41849890, 41794534, 41780402, 41770936, 41718462, 41711853, 41698160, 41671930, 41659919, 41629318, 41545413, 41538945, 41529264, 41519163, 41454539, 41443106, 41386094, 41330678, 41327249, 41249026, 41234744, 41207040, 41205456, 41175848, 41172349, 41171135, 41164194, 41161441, 41148632, 41118515, 41089000, 41067030, 41024479, 41002305, 40994449, 40968863, 40963922, 40893365, 40891676, 40870790, 40801503, 41906877, 40832436, 39923730, 39263947, 39129649, 38811951, 36190914, 35983901, 35907639, 35187107, 34619249, 34248841, 32981365, 32838280, 32527800, 31988066, 26746799, 21147843 0 familial juvenile hyperuricemic nephropathy type 2 0.7657976389758877
P10636 MAPT Microtubule-associated protein tau Tier 1 0.605 100 49.22 1 0       1 9 40380000, 39241336, 38585969, 38397086, 37003060, 31900535, 30004544, 29268187 0 Pick disease 0.7600399335134378
P46059 SLC15A1 Solute carrier family 15 member 1 Tier 1 0.603 3 87.0 1 0       1 1 26811678 0 cleft palate 0.3279926002389253

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CREATE VIEW v_targets AS
SELECT f.id, n.gene_symbol, n.protein_name, tg.tier, f.priority_score,
 f.pdb_count_total, f.alphafold_mean_pLDDT, f.has_cryoEM,
 f.has_activation_state_pdb_pair, f.activation_state_pdb_active, f.activation_state_pdb_inactive,
 f.drug_count_approved, f.has_known_aptamer, f.aptamer_count_pubmed, ap.aptamer_pmids,
 f.in_cev_map, f.opentargets_top_disease_name, f.opentargets_top_disease_score
FROM v_target_full f
LEFT JOIN target_names n ON n.target_id=f.id
LEFT JOIN targets tg ON tg.id=f.id
LEFT JOIN target_aptamer_pmids ap ON ap.target_id=f.id;