Targets — browse / sort / filter (view)

One row per human protein target with names + key evidence. Click column headers to SORT; use the facets to FILTER (tier, activation pair, known aptamer, EV-Map). UniProt IDs link to the source.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

id
UniProt accession (human). Links to uniprot.org.
gene_symbol
Gene symbol (e.g. ITGB3).
protein_name
Protein name (UniProt).
tier
Tier 1 = PDB-anchored; Tier 1.5 = AlphaFold-confident.
priority_score
Composite prioritisation = 0.30*biology + 0.30*reagent-gap + 0.20*druggability + 0.10*disease + 0.10*novelty. Sub-scores are assigned during LLM-assisted curation — a heuristic ranking, NOT an experimental measurement.
has_activation_state_pdb_pair
1 if a curated ACTIVE/INACTIVE PDB pair exists (only 11 targets).
in_cev_map
1 if in the EV-Map circulating-EV proteome (Rai 2025); 3,422 targets.
has_known_aptamer
1 if aptamer evidence found in PubMed/Aptagen (1,472 targets).
opentargets_top_disease_score
Open Targets association score (0-1).
aptamer_count_pubmed
Number of PubMed hits for this protein AND (aptamer OR SELEX).
aptamer_pmids
The actual PubMed IDs behind the aptamer evidence — click each to read the paper. This is the source of the 'has aptamer' claim.

261 rows where has_known_aptamer = 1, in_cev_map = 0 and tier = "Tier 1.5" sorted by priority_score descending

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Suggested facets: pdb_count_total

has_cryoEM 2

  • 0 211
  • 1 50

tier 1

  • Tier 1.5 · 261 ✖

in_cev_map 1

has_known_aptamer 1

has_activation_state_pdb_pair 1

  • 0 261
id gene_symbol protein_name tier priority_score ▲ pdb_count_total alphafold_mean_pLDDT has_cryoEM has_activation_state_pdb_pair activation_state_pdb_active activation_state_pdb_inactive drug_count_approved has_known_aptamer aptamer_count_pubmed aptamer_pmids in_cev_map opentargets_top_disease_name opentargets_top_disease_score
P21583 KITLG Kit ligand Tier 1.5 0.848 6 71.88 1 0       1 2 36579647, 23967247 0 hyperpigmentation with or without hypopigmentation, familial progressive 0.6756727302967072
Q00975 CACNA1B Voltage-dependent N-type calcium channel subunit alpha-1B Tier 1.5 0.807 7 59.91 1 0       1 2 31118475, 25782368 0 Seizure 0.7217241968702018
P03971 AMH Anti-Muellerian hormone Tier 1.5 0.783 3 68.62 1 0       1 2 41101154, 27364573 0 persistent Mullerian duct syndrome 0.7847328444470535
P48023 FASLG Tumor necrosis factor ligand superfamily member 6 Tier 1.5 0.775 3 80.19 0 0       1 1 16581027 0 autoimmune lymphoproliferative syndrome type 1 0.6984292519156657
Q9GZU2 PEG3 Paternally-expressed gene 3 protein Tier 1.5 0.75 1 44.53 0 0       1 1 16595502 0 neurodegenerative disease 0.34815912577489827
P18075 BMP7 Bone morphogenetic protein 7 Tier 1.5 0.749 4 76.19 0 0       1 1 30537181 0 Inguinal hernia 0.4420059023371716
Q9Y5C1 ANGPTL3 Angiopoietin-related protein 3 Tier 1.5 0.727 1 79.62 0 0       1 1 23770039 0 familial hypobetalipoproteinemia 2 0.6739043862507132
Q00604 NDP Norrin Tier 1.5 0.716 11 83.56 1 0       1 2 39057719, 11352723 0 Norrie disease 0.8566451682188412
P46094 XCR1 Chemokine XC receptor 1 Tier 1.5 0.715 1 84.94 1 0       1 1 35212764 0 COVID-19 0.459103766220463
P32239 CCKBR Gastrin/cholecystokinin type B receptor Tier 1.5 0.713 5 75.75 1 0       1 2 33776434, 27754762 0 gastroesophageal reflux disease 0.4256110167566802
P25106 ACKR3 Atypical chemokine receptor 3 Tier 1.5 0.71 14 82.44 1 0       1 2 40401615, 28670693 0 oculomotor-abducens synkinesis 0.49893280382434735
A0A0C5B5G6 MT-RNR1 Mitochondrial-derived peptide MOTS-c Tier 1.5 0.7 0 72.06 0 0       1 1 35311942 0    
P08620 FGF4 Fibroblast growth factor 4 Tier 1.5 0.7 1 81.5 0 0       1 3 35415885, 33536494, 7547864 0 cancer 0.6026669167438079
P21781 FGF7 Fibroblast growth factor 7 Tier 1.5 0.695 0 82.44 0 0       1 5 35415885, 15719578, 7547864, 16462265 0 cancer 0.5963369026823151
Q96RJ3 TNFRSF13C Tumor necrosis factor receptor superfamily member 13C Tier 1.5 0.681 8 63.03 1 0       1 1 23470998 0 immunodeficiency, common variable, 4 0.660711678987284
P26718 KLRK1 NKG2-D type II integral membrane protein Tier 1.5 0.679 22 79.19 0 0       1 1 24629635 0 Behcet's syndrome 0.18614538678991077
O95750 FGF19 Fibroblast growth factor 19 Tier 1.5 0.668 4 79.81 0 0       1 4 35415885, 31967847, 27679852 0 cancer 0.38540691230511315
O00744 WNT10B Protein Wnt-10b Tier 1.5 0.668 0 80.06 0 0       1 2 32810272, 18673242 0 Split hand-split foot malformation 0.7755225395358214
Q9HCK4 ROBO2 Roundabout homolog 2 Tier 1.5 0.665 6 67.38 0 0       1 2 40616090, 31640794 0 familial vesicoureteral reflux 0.6460375744556555
Q6PCB0 VWA1 von Willebrand factor A domain-containing protein 1 Tier 1.5 0.664 0 78.38 0 0       1 4 41906877, 41693575, 38904251, 38299345 0 neuronopathy, distal hereditary motor, autosomal recessive 7 0.7420531156755253
A2RU14 TMEM218 Transmembrane protein 218 Tier 1.5 0.663 0 87.62 0 0       1 6 41360349, 34861273, 31349094, 29277631, 26580576, 26248137 0 Joubert syndrome 39 0.7308441626389979
P18510 IL1RN Interleukin-1 receptor antagonist protein Tier 1.5 0.66 5 87.06 0 0       1 1 38928037 0 sterile multifocal osteomyelitis with periostitis and pustulosis 0.7734282711738736
Q86YL7 PDPN Podoplanin Tier 1.5 0.66 6 57.97 0 0       1 4 41304780, 41292412, 39451677 0 Microscopic hematuria 0.41183796492083136
O15389 SIGLEC5 Sialic acid-binding Ig-like lectin 5 Tier 1.5 0.656 3 77.75 0 0       1 3 33584010, 27678199, 24405684 0 dentures 0.15815607474115415
O15263 DEFB4A Defensin beta 4A Tier 1.5 0.65 6 78.0 0 0       1 2 40362575, 32067984 0 ulcerative colitis 0.09865892368546408
P84996 GNAS Protein ALEX Tier 1.5 0.65 0 43.59 0 0       1 9 39154820, 37963924, 36037714, 34488577, 31129134, 30979095, 30682825, 29146902, 28626560 0    
P01138 NGF Beta-nerve growth factor Tier 1.5 0.648 8 73.25 0 0       1 6 42015870, 38780008, 32982626, 21216401, 7545283, 29754498 0 hereditary sensory and autonomic neuropathy type 5 0.7785402119369383
Q2I0M5 RSPO4 R-spondin-4 Tier 1.5 0.646 0 78.56 0 0       1 3 38238732, 37425696 0 nonsyndromic congenital nail disorder 4 0.7604902779349189
Q9BQ51 PDCD1LG2 Programmed cell death 1 ligand 2 Tier 1.5 0.645 2 86.38 0 0       1 1 38928037 0 melanoma 0.42716921377769757
P08100 RHO Rhodopsin Tier 1.5 0.645 4 88.75 1 0       1 45 41963275, 41924874, 41636061, 40808302, 40642289, 40330320, 40045571, 39863313, 39788632, 38070612, 37191882, 36705086, 36696850, 36095194, 36049339, 35622174, 34709779, 34471566, 32696702, 32479610, 32319623, 32119944, 31737572, 31588238, 31535128, 29570714, 29281176, 28648779, 27893356, 25645980, 23757206, 23701883, 25033804, 22689339, 22302221, 22121695, 19766091, 19389625, 16419035, 12123800, 8743323, 7678562, 19188685, 18230760 0 retinitis pigmentosa 0.8481942240861982
Q9UKP5 ADAMTS6 A disintegrin and metalloproteinase with thrombospondin motifs 6 Tier 1.5 0.644 0 77.5 0 0       1 1 35700850 0 Abnormality of the skeletal system 0.5444162515485208
P15391 CD19 B-lymphocyte antigen CD19 Tier 1.5 0.642 4 62.22 1 0       1 13 41079126, 40652441, 38661725, 38148412, 36095289, 35829681, 34680368, 34364920, 32401486, 31912987, 29928472, 21127492 0 immunodeficiency, common variable, 3 0.6821072538733047
Q8NEV9 IL27 Interleukin-27 subunit alpha Tier 1.5 0.641 4 75.62 1 0       1 2 35859339, 32784904 0 Crohn's disease 0.40963715551754365
P07202 TPO Thyroid peroxidase Tier 1.5 0.64 0 83.44 0 0       1 1 29881374 0 familial thyroid dyshormonogenesis 0.6710562308468054
P45844 ABCG1 ATP-binding cassette sub-family G member 1 Tier 1.5 0.639 5 81.12 1 0       1 1 41854184 0 neurodegenerative disease 0.3915225348167794
P31994 FCGR2B Low affinity immunoglobulin gamma Fc region receptor II-b Tier 1.5 0.636 5 78.44 0 0       1 1 38928037 0 systemic lupus erythematosus 0.460465747544726
P51654 GPC3 Glypican-3 Tier 1.5 0.636 4 75.06 1 0       1 65 42083729, 41790019, 41653459, 41045695, 40825648, 40722645, 39998646, 39874791, 39608318, 39427046, 38910291, 38787447, 38621313, 38368644, 37665421, 36903516, 36457288, 36317566, 36072763, 35788872, 35699181, 35477501, 35051745, 34974867, 34306031, 33254049, 33080969, 32356075, 30347351, 30122918, 29675356, 29605994, 29277631, 27601357, 28263753 0 Simpson-Golabi-Behmel syndrome type 1 0.762708583613362
Q16674 MIA Melanoma-derived growth regulatory protein Tier 1.5 0.636 4 86.38 0 0       1 15 41768714, 40943389, 40444021, 38899488, 37853818, 35842727, 35593028, 35061691, 34038704, 32957732, 31878307, 31289496, 29499935, 28059418, 26840019 0 neurodegenerative disease 0.36367051545295126
P31785 IL2RG Cytokine receptor common subunit gamma Tier 1.5 0.635 14 75.5 1 0       1 2 30800133, 33869115 0 gamma chain deficiency 0.8469997000418428
Q92563 SPOCK2 Testican-2 Tier 1.5 0.627 0 66.94 0 0       1 8 39695715, 35474272, 32958645, 28794177, 38656806, 36288905 0 Back pain 0.3687304175767662
P34810 CD68 Macrosialin Tier 1.5 0.627 0 73.19 0 0       1 4 37422510, 33321636, 28315675, 27940247 0 neurodegenerative disease 0.3710186480081222
O95342 ABCB11 Bile salt export pump Tier 1.5 0.624 8 83.12 1 0       1 1 36313979 0 progressive familial intrahepatic cholestasis type 2 0.8372060401943777
Q96NZ8 WFIKKN1 WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 Tier 1.5 0.621 2 78.06 0 0       1 1 33591955 0 neurodegenerative disease 0.3060887002952384
P49238 CX3CR1 CX3C chemokine receptor 1 Tier 1.5 0.62 2 80.5 1 0       1 2 28727998 0 age-related macular degeneration 0.4006854573775187
Q06141 REG3A Regenerating islet-derived protein 3-alpha Tier 1.5 0.62 4 89.0 1 0       1 2 39695715, 24771595 0 alcohol drinking 0.29724052454892086
Q13508 ART3 Ecto-ADP-ribosyltransferase 3 Tier 1.5 0.62 0 74.0 0 0       1 5 41503480, 41083485, 41020397, 40313273, 41325160 0 type 2 diabetes mellitus 0.3004670185438895
O43435 TBX1 T-box transcription factor TBX1 Tier 1.5 0.619 1 68.19 0 0       1 1 24797903 0 22q11.2 deletion syndrome 0.8406035626999856
Q96MS0 ROBO3 Roundabout homolog 3 Tier 1.5 0.618 3 63.69 0 0       1 2 32369590 0 horizontal gaze palsy with progressive scoliosis 0.7813306356858872
Q07325 CXCL9 C-X-C motif chemokine 9 Tier 1.5 0.617 1 87.44 1 0       1 7 42046114, 37395276, 35204399, 35018777, 33742062, 27959341, 27819142 0 neoplasm 0.1199067650750674
O60938 KERA Keratocan Tier 1.5 0.612 0 87.56 0 0       1 3 37696275, 41280530, 38079395 0 cornea plana 2 0.7200491760465073

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CREATE VIEW v_targets AS
SELECT f.id, n.gene_symbol, n.protein_name, tg.tier, f.priority_score,
 f.pdb_count_total, f.alphafold_mean_pLDDT, f.has_cryoEM,
 f.has_activation_state_pdb_pair, f.activation_state_pdb_active, f.activation_state_pdb_inactive,
 f.drug_count_approved, f.has_known_aptamer, f.aptamer_count_pubmed, ap.aptamer_pmids,
 f.in_cev_map, f.opentargets_top_disease_name, f.opentargets_top_disease_score
FROM v_target_full f
LEFT JOIN target_names n ON n.target_id=f.id
LEFT JOIN targets tg ON tg.id=f.id
LEFT JOIN target_aptamer_pmids ap ON ap.target_id=f.id;