Targets — browse / sort / filter (view)

One row per human protein target with names + key evidence. Click column headers to SORT; use the facets to FILTER (tier, activation pair, known aptamer, EV-Map). UniProt IDs link to the source.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

id
UniProt accession (human). Links to uniprot.org.
gene_symbol
Gene symbol (e.g. ITGB3).
protein_name
Protein name (UniProt).
tier
Tier 1 = PDB-anchored; Tier 1.5 = AlphaFold-confident.
priority_score
Composite prioritisation = 0.30*biology + 0.30*reagent-gap + 0.20*druggability + 0.10*disease + 0.10*novelty. Sub-scores are assigned during LLM-assisted curation — a heuristic ranking, NOT an experimental measurement.
has_activation_state_pdb_pair
1 if a curated ACTIVE/INACTIVE PDB pair exists (only 11 targets).
in_cev_map
1 if in the EV-Map circulating-EV proteome (Rai 2025); 3,422 targets.
has_known_aptamer
1 if aptamer evidence found in PubMed/Aptagen (1,472 targets).
opentargets_top_disease_score
Open Targets association score (0-1).
aptamer_count_pubmed
Number of PubMed hits for this protein AND (aptamer OR SELEX).
aptamer_pmids
The actual PubMed IDs behind the aptamer evidence — click each to read the paper. This is the source of the 'has aptamer' claim.

238 rows where has_known_aptamer = 1, in_cev_map = 1 and tier = "Tier 1.5" sorted by priority_score descending

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Suggested facets: pdb_count_total

has_cryoEM 2

  • 0 186
  • 1 52

has_activation_state_pdb_pair 2

  • 0 237
  • 1 1

tier 1

  • Tier 1.5 · 238 ✖

in_cev_map 1

has_known_aptamer 1

id gene_symbol protein_name tier priority_score ▲ pdb_count_total alphafold_mean_pLDDT has_cryoEM has_activation_state_pdb_pair activation_state_pdb_active activation_state_pdb_inactive drug_count_approved has_known_aptamer aptamer_count_pubmed aptamer_pmids in_cev_map opentargets_top_disease_name opentargets_top_disease_score
P25445 FAS Tumor necrosis factor receptor superfamily member 6 Tier 1.5 0.914 7 77.88 1 0       1 17 40784034, 39897575, 37458448, 36908619, 35402075, 32270033, 31436946, 30594071, 30417194, 30339905, 26318819, 23980164, 23511245, 18997060, 18956014, 16729304, 16581027 1 autoimmune lymphoproliferative syndrome type 1 0.7377210386590284
P15260 IFNGR1 Interferon gamma receptor 1 Tier 1.5 0.804 5 66.0 0 0       1 2 33667716 1 disseminated atypical mycobacterial infection 0.5414012388034828
P02748 C9 Complement component C9 Tier 1.5 0.796 9 78.75 1 0       1 10 41636061, 40411682, 36428893, 36290981, 35247355, 28794177, 27836219, 22678933, 19261617, 15687383 1 Immunodeficiency due to a late component of complements deficiency 0.761965409699055
Q13085 ACACA Acetyl-CoA carboxylase 1 Tier 1.5 0.79 10 82.81 1 0       1 1 41854184 1    
P36888 FLT3 Receptor-type tyrosine-protein kinase FLT3 Tier 1.5 0.788 11 75.94 0 0       1 6 41733039, 34364920, 31434881, 30237882, 29299123, 22411871 1 acute myeloid leukemia 0.8313389209288576
Q92633 LPAR1 Lysophosphatidic acid receptor 1 Tier 1.5 0.785 16 83.62 1 0       1 1 32065590 1 Epiretinal membrane 0.4757255248053499
P02776 PF4 Platelet factor 4 Tier 1.5 0.77 10 75.06 0 0       1 10 33859620, 32366845, 31967847, 23847186, 23673861, 34248840, 32022468 1 systemic scleroderma 0.11523541376593864
P39060 COL18A1 Collagen alpha-1(XVIII) chain Tier 1.5 0.769 9 50.62 1 0       1 2 36707842, 23679916 1 Knobloch syndrome 1 0.7867122552672962
P43007 SLC1A4 Neutral amino acid transporter A Tier 1.5 0.75 1 80.56 1 0       1 6 36219068, 31989939, 27571928, 26811678, 19046328, 16139842 1 spastic tetraplegia-thin corpus callosum-progressive postnatal microcephaly syndrome 0.8025684205131692
P08648 ITGA5 Integrin alpha-5 Tier 1.5 0.748 14 85.25 1 0       1 2 32174798, 38258032 1 skin disease 0.28465651599598124
O60884 DNAJA2 DnaJ homolog subfamily A member 2 Tier 1.5 0.73 1 83.38 1 0       1 2 41935727, 33879515 1 dengue disease 0.37068859424875583
Q99988 GDF15 Growth/differentiation factor 15 Tier 1.5 0.718 4 75.69 1 0       1 29 41924874, 41862097, 38879214, 38477735, 37982669, 36927042, 36638554, 36508319, 36333824, 35762561, 33334063, 32527800, 31988066, 29992704, 39884764, 38497478, 38296402, 37162508, 32739349, 30335547 1 hyperemesis gravidarum 0.5821658682742563
P41221 WNT5A Protein Wnt-5a Tier 1.5 0.71 0 87.69 0 0       1 4 40855286, 32693649, 22363130, 18673242 1 Robinow syndrome 0.7220360983378594
P07225 PROS1 Vitamin K-dependent protein S Tier 1.5 0.7 3 82.94 1 0       1 2 36859809, 33674695 1 thrombophilia due to protein S deficiency, autosomal dominant 0.8240418292042652
P19021 PAM Peptidyl-glycine alpha-amidating monooxygenase Tier 1.5 0.695 0 71.69 0 0       1 25 41855944, 41500123, 41384307, 41285544, 41222440, 40607956, 39929897, 39472107, 38867016, 38846799, 37977804, 37977780, 37906116, 37127012, 36905684, 35478209, 33911033, 33516855, 32315032, 32307868, 30399413, 30124431, 26406332, 22954359, 14965210 1 type 2 diabetes mellitus 0.5754371880839976
P21359 NF1 Neurofibromin Tier 1.5 0.695 26 87.19 1 0       1 2 32980430, 22617876 1 neurofibromatosis type 1 0.8844735398780649
P10586 PTPRF Receptor-type tyrosine-protein phosphatase F Tier 1.5 0.69 13 82.0 0 0       1 4 42101929, 39087949, 36594741 1 smoking initiation 0.4641111755355386
O00501 CLDN5 Claudin-5 Tier 1.5 0.685 0 83.75 0 0       1 1 18951306 1 genetic disorder 0.40861362787778505
P14384 CPM Carboxypeptidase M Tier 1.5 0.68 1 90.31 0 0       1 3 38876068, 38060303, 36768220 1 hydronephrosis 0.3163273148871551
P09758 TACSTD2 Tumor-associated calcium signal transducer 2 Tier 1.5 0.673 7 82.69 0 0       1 4 41384307, 41241473, 40050871, 39250993 1 gelatinous drop-like corneal dystrophy 0.7293087728162646
P98066 TNFAIP6 Tumor necrosis factor-inducible gene 6 protein Tier 1.5 0.671 5 81.12 0 0       1 1 39263947 1 type 2 diabetes mellitus 0.30862220597837015
P16870 CPE Carboxypeptidase E Tier 1.5 0.66 0 90.38 0 0       1 16 39863729, 39793371, 38861005, 36832010, 36773630, 27886773, 27219679, 25738486, 28706644, 24768847, 23875581, 22280349, 21419619, 20949139, 20491465, 19174227 1 BDV syndrome 0.7029731914682913
P98155 VLDLR Very low-density lipoprotein receptor Tier 1.5 0.66 27 75.69 1 0       1 1 19188685 1 Dysequilibrium syndrome 0.790164037509625
P22692 IGFBP4 Insulin-like growth factor-binding protein 4 Tier 1.5 0.66 4 77.25 0 0       1 6 35323639, 32515246, 31930684 1 allergic rhinitis 0.35214760515440524
Q13433 SLC39A6 Zinc transporter ZIP6 Tier 1.5 0.66 0 60.44 0 0       1 1 40132409 1 breast cancer 0.11188167100061543
Q9Y625 GPC6 Glypican-6 Tier 1.5 0.655 0 82.0 0 0       1 1 40093223 1 autosomal recessive omodysplasia 0.7503216726357611
P02766 TTR Transthyretin Tier 1.5 0.655 0 88.0 0 0       1 11 39737993, 32616928, 23770039, 21875107, 21314458, 39596348, 38399458, 36881759, 33572452 1 amyloidosis, hereditary systemic 1 0.846421986844374
Q9H0R3 TMEM222 Transmembrane protein 222 Tier 1.5 0.654 0 84.81 0 0       1 3 41643149, 36174865, 25998051 1 neurodevelopmental disorder with motor and speech delay and behavioral abnormalities 0.6449281600938256
P16234 PDGFRA Platelet-derived growth factor receptor alpha Tier 1.5 0.652 14 72.69 1 0       1 4 33334063, 32127469, 28010895, 30594071 1 gastrointestinal stromal tumor 0.8167494524079806
P32942 ICAM3 Intercellular adhesion molecule 3 Tier 1.5 0.648 1 87.12 0 0       1 3 40650261, 34730968, 17660953 1 lymphatic system disease 0.28331776251399693
P07237 P4HB Protein disulfide-isomerase Tier 1.5 0.644 14 88.5 1 0       1 2 31625090, 28952381 1 Cole-Carpenter syndrome 0.7447295842045853
Q14242 SELPLG P-selectin glycoprotein ligand 1 Tier 1.5 0.64 1 50.38 0 0       1 1 25979951 1 glaucoma 0.40058604767334977
P01732 CD8A T-cell surface glycoprotein CD8 alpha chain Tier 1.5 0.635 8 78.19 0 0       1 2 38487531, 36979667 1 progressive supranuclear palsy 0.2036023725502463
P51884 LUM Lumican Tier 1.5 0.625 0 90.38 0 0       1 7 41744190, 36785906, 28453726, 26230699, 24180352, 23890607 1 lumbar disc herniation 0.3492311458288365
O75976 CPD Carboxypeptidase D Tier 1.5 0.625 3 82.5 1 0       1 1 36457699 1 neurodegenerative disease 0.34777406871587735
P49862 KLK7 Kallikrein-7 Tier 1.5 0.624 12 91.56 0 0       1 1 30114962 1 neurodegenerative disease 0.2420324965785189
P21926 CD9 CD9 antigen Tier 1.5 0.623 5 88.56 0 0       1 17 41999228, 41625383, 40618375, 39266887, 38866706, 38057814, 37585601, 37351166, 37019008, 36704890, 34647460, 34505435, 33304477, 32730952, 32207293, 28959386 1 diphtheria 0.5261379875719714
P16671 CD36 Platelet glycoprotein 4 Tier 1.5 0.62 1 93.94 0 0       1 6 41713143, 41140242, 39762152, 33596054, 33291667, 31904170 1 platelet-type bleeding disorder 10 0.7360571429413174
Q9ULC3 RAB23 Ras-related protein Rab-23 Tier 1.5 0.619 6 79.56 1 0       1 1 23618401 1 RAB23-related Carpenter syndrome 0.7879955689930709
P10451 SPP1 Osteopontin Tier 1.5 0.615 3 53.41 0 0       1 62 41690559, 41223977, 39422353, 38600327, 32943056, 32042311, 31603904, 30307407, 28916037, 28453726, 25278703, 21147843, 42136308, 42108056, 40845664, 40479828, 39677448, 39340832, 38834269, 37162508, 36508319, 36284815, 35433114, 35190123, 34420232, 32166466, 31987218, 31879964, 31806966, 31301870, 30135425, 29441346, 28988933, 28706912, 26529285, 25949891, 25930003, 25713073, 24902765, 24491763, 24438228, 23889968, 23619316, 22880609, 22241292, 21962803, 21801960, 20967826, 19570203, 18985031 1 osteoporosis 0.5729473764531288
P01876 IGHA1 Immunoglobulin heavy constant alpha 1 Tier 1.5 0.612 14 81.88 1 0       1 2 37325361 1 IGA glomerulonephritis 0.12053726815801102
O43866 CD5L CD5 antigen-like Tier 1.5 0.61 4 85.88 1 0       1 3 40215752, 37100807 1 functional neutrophil defect 0.3529395470693119
O75487 GPC4 Glypican-4 Tier 1.5 0.61 0 83.19 0 0       1 1 40766128 1 Keipert syndrome 0.737596102373947
P23368 ME2 NAD-dependent malic enzyme, mitochondrial Tier 1.5 0.61 18 94.38 1 0       1 2 39602246, 29779113 1 diabetes mellitus 0.277416610655893
Q12891 HYAL2 Hyaluronidase-2 Tier 1.5 0.61 0 91.0 0 0       1 1 37353120 1 Muggenthaler-Chowdhury-Chioza syndrome 0.6952425210951342
P15529 CD46 Membrane cofactor protein Tier 1.5 0.608 7 82.12 1 0       1 9 35114109, 34248841, 31761039, 31077760, 27734375, 19915929, 17046833, 11084032 1 atypical hemolytic-uremic syndrome with MCP/CD46 anomaly 0.7798469882597787
P55157 MTTP Microsomal triglyceride transfer protein large subunit Tier 1.5 0.608 2 86.56 1 0       1 1 23770039 1 abetalipoproteinemia 0.8281089516017405
O75508 CLDN11 Claudin-11 Tier 1.5 0.608 0 85.75 0 0       1 1 35207732 1 leukodystrophy, hypomyelinating, 22 0.6787731842933689
P10646 TFPI Tissue factor pathway inhibitor Tier 1.5 0.605 9 73.62 1 0       1 28 32366845, 32224381, 30994257, 30302740, 27563744, 27196067, 24263002, 23528042, 22951415, 22658294, 22632032, 22239993, 21696535, 21389323, 8578509, 25521966, 24319161 1 hemophilia A 0.5591056672248635
P10909 CLU Clusterin Tier 1.5 0.605 2 77.31 0 0       1 5 42041411, 37179603, 36980195, 35383192, 26061649 1 Alzheimer disease 0.5545645077431476

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CREATE VIEW v_targets AS
SELECT f.id, n.gene_symbol, n.protein_name, tg.tier, f.priority_score,
 f.pdb_count_total, f.alphafold_mean_pLDDT, f.has_cryoEM,
 f.has_activation_state_pdb_pair, f.activation_state_pdb_active, f.activation_state_pdb_inactive,
 f.drug_count_approved, f.has_known_aptamer, f.aptamer_count_pubmed, ap.aptamer_pmids,
 f.in_cev_map, f.opentargets_top_disease_name, f.opentargets_top_disease_score
FROM v_target_full f
LEFT JOIN target_names n ON n.target_id=f.id
LEFT JOIN targets tg ON tg.id=f.id
LEFT JOIN target_aptamer_pmids ap ON ap.target_id=f.id;