Targets — browse / sort / filter (view)

One row per human protein target with names + key evidence. Click column headers to SORT; use the facets to FILTER (tier, activation pair, known aptamer, EV-Map). UniProt IDs link to the source.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

id
UniProt accession (human). Links to uniprot.org.
gene_symbol
Gene symbol (e.g. ITGB3).
protein_name
Protein name (UniProt).
tier
Tier 1 = PDB-anchored; Tier 1.5 = AlphaFold-confident.
priority_score
Composite prioritisation = 0.30*biology + 0.30*reagent-gap + 0.20*druggability + 0.10*disease + 0.10*novelty. Sub-scores are assigned during LLM-assisted curation — a heuristic ranking, NOT an experimental measurement.
has_activation_state_pdb_pair
1 if a curated ACTIVE/INACTIVE PDB pair exists (only 11 targets).
in_cev_map
1 if in the EV-Map circulating-EV proteome (Rai 2025); 3,422 targets.
has_known_aptamer
1 if aptamer evidence found in PubMed/Aptagen (1,472 targets).
opentargets_top_disease_score
Open Targets association score (0-1).
aptamer_count_pubmed
Number of PubMed hits for this protein AND (aptamer OR SELEX).
aptamer_pmids
The actual PubMed IDs behind the aptamer evidence — click each to read the paper. This is the source of the 'has aptamer' claim.

3,776 rows where in_cev_map = 0 sorted by priority_score descending

✎ View and edit SQL

This data as json, CSV (advanced)

tier 2

has_known_aptamer 2

  • 0 3,147
  • 1 629

has_cryoEM 2

  • 0 2,982
  • 1 794

in_cev_map 1

  • - · 3,776 ✖

has_activation_state_pdb_pair 1

  • 0 3,776
id gene_symbol protein_name tier priority_score ▲ pdb_count_total alphafold_mean_pLDDT has_cryoEM has_activation_state_pdb_pair activation_state_pdb_active activation_state_pdb_inactive drug_count_approved has_known_aptamer aptamer_count_pubmed aptamer_pmids in_cev_map opentargets_top_disease_name opentargets_top_disease_score
P12263     Tier 1 0.9 7 63.59 1 0       0 0   0    
Q12879 GRIN2A Glutamate receptor ionotropic, NMDA 2A Tier 1 0.88 37 60.84 1 0       0 0   0 Landau-Kleffner syndrome 0.8407159711916629
Q9Y2C5 SLC17A4 Probable small intestine urate exporter Tier 1.5 0.878 0 83.69 0 0       0 0   0 inflammatory bowel disease 0.09896486250497885
P23946 CMA1 Chymase Tier 1 0.875 42 91.31 0 0       1 1 30572223 0 pernicious anemia 0.17348905136256007
Q9UJA9 ENPP5 Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 Tier 1 0.87 1 88.12 0 0       0 0   0 neurodegenerative disease 0.33211724272317855
P21583 KITLG Kit ligand Tier 1.5 0.848 6 71.88 1 0       1 2 36579647, 23967247 0 hyperpigmentation with or without hypopigmentation, familial progressive 0.6756727302967072
P35346 SSTR5 Somatostatin receptor type 5 Tier 1.5 0.841 7 81.25 1 0       0 0   0 acromegaly 0.6094707180356006
Q5T848 GPR158 Metabotropic glycine receptor Tier 1 0.839 6 58.03 1 0       0 0   0 diverticular disease 0.4384404783771627
P21439 ABCB4 Phosphatidylcholine translocator ABCB4 Tier 1.5 0.835 4 83.25 1 0       0 0   0 progressive familial intrahepatic cholestasis type 3 0.851728159166962
Q31135 H2-Ab1   Tier 1 0.83 12 85.12 0 0       0 0   0    
P0DSE2 TRB M1-specific T cell receptor beta chain Tier 1 0.83 5 90.12 1 0       0 0   0    
O75899 GABBR2 Gamma-aminobutyric acid type B receptor subunit 2 Tier 1.5 0.824 26 77.75 1 0       0 0   0 developmental and epileptic encephalopathy, 59 0.7356789732167734
A0A0E3EAY4 env Envelope glycoprotein gp160 Tier 1 0.82 2   1 0       1 12 36576612, 29464116, 29217761, 22379083, 18776229, 18569791, 16146716, 16043495, 16013840, 12498773, 11024283, 9713975 0    
Q00975 CACNA1B Voltage-dependent N-type calcium channel subunit alpha-1B Tier 1.5 0.807 7 59.91 1 0       1 2 31118475, 25782368 0 Seizure 0.7217241968702018
P0DPK4 NOTCH2NLC Notch homolog 2 N-terminal-like protein C Tier 1.5 0.805 0 80.81 0 0       0 0   0 neuronal intranuclear inclusion disease 0.4999829066911242
Q9NS82 SLC7A10 Asc-type amino acid transporter 1 Tier 1 0.803 4 83.38 1 0       0 0   0 asthma 0.5295411410172121
Q04844 CHRNE Acetylcholine receptor subunit epsilon Tier 1.5 0.802 13 80.69 1 0       0 0   0 Congenital myasthenic syndromes 0.8223287249629152
O60895 RAMP2 Receptor activity-modifying protein 2 Tier 1 0.802 10 80.94 1 0       0 0   0 diabetes mellitus 0.4219370007650345
P29275 ADORA2B Adenosine receptor A2b Tier 1.5 0.801 4 88.12 1 0       0 0   0 migraine disorder 0.6060142180667235
Q9H2X9 SLC12A5 Solute carrier family 12 member 5 Tier 1.5 0.8 2 78.44 1 0       0 0   0 genetic developmental and epileptic encephalopathy 0.6993945840545625
P35414 APLNR Apelin receptor Tier 1 0.8 37 81.69 1 0       1 1 36126144 0 essential hypertension 0.2159614840844307
P01236 PRL Prolactin Tier 1 0.795 12 85.56 0 0       1 6 40327044, 30834248, 29277631, 28263753, 27679852, 16947086 0 AL amyloidosis 0.4619748183558772
P01909 HLA-DQA1 HLA class II histocompatibility antigen, DQ alpha 1 chain Tier 1 0.792 27 87.94 1 0       0 0   0 Pleural Mesothelioma 0.1228600330569846
Q13705 ACVR2B Activin receptor type-2B Tier 1.5 0.791 9 83.31 1 0       0 0   0 Heterotaxia 0.7109733260300651
Q96CS2 HAUS1 HAUS augmin-like complex subunit 1 Tier 1.5 0.79 1 88.62 1 0       0 0   0 device complication 0.27547205131467467
Q14031 COL4A6 Collagen alpha-6(IV) chain Tier 1.5 0.79 0 47.41 0 0       0 0   0 Dupuytren Contracture 0.5880367459451578
O14788 TNFSF11 Tumor necrosis factor ligand superfamily member 11 Tier 1 0.79 2 79.19 0 0       1 2 15562003, 41226313 0 osteoporosis 0.6957850224892792
P03971 AMH Anti-Muellerian hormone Tier 1.5 0.783 3 68.62 1 0       1 2 41101154, 27364573 0 persistent Mullerian duct syndrome 0.7847328444470535
Q5JUK3 KCNT1 Potassium channel subfamily T member 1 Tier 1.5 0.782 6 73.88 1 0       0 0   0 developmental and epileptic encephalopathy, 14 0.8165232785825526
Q13639     Tier 1 0.781 3 80.88 1 0       0 0   0 schizophrenia 0.6060830827022777
P37023 ACVRL1 Activin receptor type-1-like Tier 1.5 0.779 7 82.0 0 0       0 0   0 telangiectasia, hereditary hemorrhagic, type 2 0.7951167515831324
P01568 IFNA21 Interferon alpha-21 Tier 1.5 0.777 0 85.0 0 0       0 0   0 renal cell carcinoma 0.3695798546847018
P30542 ADORA1 Adenosine receptor A1 Tier 1.5 0.777 5 92.44 1 0       0 0   0 asthma 0.7232344154541454
P13866 SLC5A1 Sodium/glucose cotransporter 1 Tier 1.5 0.777 4 84.38 1 0       0 0   0 glucose-galactose malabsorption 0.8220991027793896
P48023 FASLG Tumor necrosis factor ligand superfamily member 6 Tier 1.5 0.775 3 80.19 0 0       1 1 16581027 0 autoimmune lymphoproliferative syndrome type 1 0.6984292519156657
O15393     Tier 1 0.775 31 79.38 1 0       0 0   0 COVID-19 0.6157541390484623
P07911 UMOD Uromodulin Tier 1 0.774 10 82.94 1 0       1 4 37533140, 35446786 0 familial juvenile hyperuricemic nephropathy type 1 0.8446536377993564
A6ND01 IZUMO1R Sperm-egg fusion protein Juno Tier 1 0.773 7 87.38 0 0       0 0   0 placental retention 0.23306495563589497
Q9BVX2 TMEM106C Transmembrane protein 106C Tier 1.5 0.77 0 80.81 0 0       0 0   0 prostate carcinoma 0.21737104399686757
P29017 CD1C T-cell surface glycoprotein CD1c Tier 1.5 0.77 10 88.56 0 0       0 0   0 neoplasm 0.1106047389635713
A0A5H2UYS3 HLA-A   Tier 1 0.77 20 85.25 0 0       0 0   0    
P29460 IL12B Interleukin-12 subunit beta Tier 1 0.769 20 91.12 1 0       0 0   0 psoriasis 0.7914863943708039
P43004 SLC1A2 Excitatory amino acid transporter 2 Tier 1.5 0.768 7 77.75 1 0       0 0   0 developmental and epileptic encephalopathy, 41 0.7772658651722512
P26951 IL3RA Interleukin-3 receptor subunit alpha Tier 1 0.767 4 85.25 0 0       1 3 40931580, 36171541, 31323275 0 acute myeloid leukemia 0.46904332714118013
O60931 CTNS Cystinosin Tier 1.5 0.764 6 89.44 1 0       0 0   0 nephropathic cystinosis 0.841818398377195
A0A1B0GTW7 CIROP Ciliated left-right organizer metallopeptidase Tier 1.5 0.764 0 73.44 0 0       0 0   0 heterotaxy, visceral, 12, autosomal 0.6929422132808513
Q9Y5Y9 SCN10A Sodium channel protein type 10 subunit alpha Tier 1.5 0.761 8 67.31 1 0       0 0   0 atrial fibrillation 0.7126293968222049
P98073     Tier 1 0.761 14 81.5 1 0       0 0   0 congenital enteropathy due to enteropeptidase deficiency 0.7102613227574134
Q9BZR8 BCL2L14 Apoptosis facilitator Bcl-2-like protein 14 Tier 1.5 0.76 0 62.38 0 0       0 0   0 hypothyroidism 0.33117514363294837
Q9BWF2 TRAIP E3 ubiquitin-protein ligase TRAIP Tier 1.5 0.76 1 74.94 0 0       0 0   0 Seckel syndrome 9 0.683878095944948

Next page

Advanced export

JSON shape: default, array, newline-delimited

CSV options: 

CREATE VIEW v_targets AS
SELECT f.id, n.gene_symbol, n.protein_name, tg.tier, f.priority_score,
 f.pdb_count_total, f.alphafold_mean_pLDDT, f.has_cryoEM,
 f.has_activation_state_pdb_pair, f.activation_state_pdb_active, f.activation_state_pdb_inactive,
 f.drug_count_approved, f.has_known_aptamer, f.aptamer_count_pubmed, ap.aptamer_pmids,
 f.in_cev_map, f.opentargets_top_disease_name, f.opentargets_top_disease_score
FROM v_target_full f
LEFT JOIN target_names n ON n.target_id=f.id
LEFT JOIN targets tg ON tg.id=f.id
LEFT JOIN target_aptamer_pmids ap ON ap.target_id=f.id;