Targets — browse / sort / filter (view)

One row per human protein target with names + key evidence. Click column headers to SORT; use the facets to FILTER (tier, activation pair, known aptamer, EV-Map). UniProt IDs link to the source.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

id
UniProt accession (human). Links to uniprot.org.
gene_symbol
Gene symbol (e.g. ITGB3).
protein_name
Protein name (UniProt).
tier
Tier 1 = PDB-anchored; Tier 1.5 = AlphaFold-confident.
priority_score
Composite prioritisation = 0.30*biology + 0.30*reagent-gap + 0.20*druggability + 0.10*disease + 0.10*novelty. Sub-scores are assigned during LLM-assisted curation — a heuristic ranking, NOT an experimental measurement.
has_activation_state_pdb_pair
1 if a curated ACTIVE/INACTIVE PDB pair exists (only 11 targets).
in_cev_map
1 if in the EV-Map circulating-EV proteome (Rai 2025); 3,422 targets.
has_known_aptamer
1 if aptamer evidence found in PubMed/Aptagen (1,472 targets).
opentargets_top_disease_score
Open Targets association score (0-1).
aptamer_count_pubmed
Number of PubMed hits for this protein AND (aptamer OR SELEX).
aptamer_pmids
The actual PubMed IDs behind the aptamer evidence — click each to read the paper. This is the source of the 'has aptamer' claim.

3,886 rows where tier = "Tier 1.5" sorted by priority_score descending

✎ View and edit SQL

This data as json, CSV (advanced)

Suggested facets: pdb_count_total

in_cev_map 2

  • 0 2,348
  • 1 1,538

has_known_aptamer 2

  • 0 3,386
  • 1 499

has_cryoEM 2

  • 0 3,374
  • 1 511

has_activation_state_pdb_pair 2

  • 0 3,884
  • 1 1

tier 1

  • Tier 1.5 · 3,886 ✖
id gene_symbol protein_name tier priority_score ▲ pdb_count_total alphafold_mean_pLDDT has_cryoEM has_activation_state_pdb_pair activation_state_pdb_active activation_state_pdb_inactive drug_count_approved has_known_aptamer aptamer_count_pubmed aptamer_pmids in_cev_map opentargets_top_disease_name opentargets_top_disease_score
P25445 FAS Tumor necrosis factor receptor superfamily member 6 Tier 1.5 0.914 7 77.88 1 0       1 17 40784034, 39897575, 37458448, 36908619, 35402075, 32270033, 31436946, 30594071, 30417194, 30339905, 26318819, 23980164, 23511245, 18997060, 18956014, 16729304, 16581027 1 autoimmune lymphoproliferative syndrome type 1 0.7377210386590284
Q9Y2C5 SLC17A4 Probable small intestine urate exporter Tier 1.5 0.878 0 83.69 0 0       0 0   0 inflammatory bowel disease 0.09896486250497885
Q9NX14 NDUFB11 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial Tier 1.5 0.86 0 77.56 0 0       0 0   1 Microphthalmia with linear skin defects syndrome 0.7364493324598024
P21583 KITLG Kit ligand Tier 1.5 0.848 6 71.88 1 0       1 2 36579647, 23967247 0 hyperpigmentation with or without hypopigmentation, familial progressive 0.6756727302967072
P35346 SSTR5 Somatostatin receptor type 5 Tier 1.5 0.841 7 81.25 1 0       0 0   0 acromegaly 0.6094707180356006
Q02094 RHAG Ammonium transporter Rh type A Tier 1.5 0.841 8 95.62 1 0       0 0   1 Rh deficiency syndrome 0.764209214915708
Q14392 LRRC32 Transforming growth factor beta activator LRRC32 Tier 1.5 0.838 6 86.06 1 0       0 0   1 cleft palate, proliferative retinopathy, and developmental delay 0.5770707112957068
P21439 ABCB4 Phosphatidylcholine translocator ABCB4 Tier 1.5 0.835 4 83.25 1 0       0 0   0 progressive familial intrahepatic cholestasis type 3 0.851728159166962
P12532 CKMT1A Creatine kinase U-type, mitochondrial Tier 1.5 0.83 9 89.31 1 0       0 0   1 neurodegenerative disease 0.5385822922582763
O75899 GABBR2 Gamma-aminobutyric acid type B receptor subunit 2 Tier 1.5 0.824 26 77.75 1 0       0 0   0 developmental and epileptic encephalopathy, 59 0.7356789732167734
P54709 ATP1B3 Sodium/potassium-transporting ATPase subunit beta-3 Tier 1.5 0.81 7 89.69 1 0       0 0   1 congestive heart failure 0.5999952111132625
Q00975 CACNA1B Voltage-dependent N-type calcium channel subunit alpha-1B Tier 1.5 0.807 7 59.91 1 0       1 2 31118475, 25782368 0 Seizure 0.7217241968702018
P0DPK4 NOTCH2NLC Notch homolog 2 N-terminal-like protein C Tier 1.5 0.805 0 80.81 0 0       0 0   0 neuronal intranuclear inclusion disease 0.4999829066911242
P15260 IFNGR1 Interferon gamma receptor 1 Tier 1.5 0.804 5 66.0 0 0       1 2 33667716 1 disseminated atypical mycobacterial infection 0.5414012388034828
Q04844 CHRNE Acetylcholine receptor subunit epsilon Tier 1.5 0.802 13 80.69 1 0       0 0   0 Congenital myasthenic syndromes 0.8223287249629152
P29275 ADORA2B Adenosine receptor A2b Tier 1.5 0.801 4 88.12 1 0       0 0   0 migraine disorder 0.6060142180667235
Q9H2X9 SLC12A5 Solute carrier family 12 member 5 Tier 1.5 0.8 2 78.44 1 0       0 0   0 genetic developmental and epileptic encephalopathy 0.6993945840545625
P02748 C9 Complement component C9 Tier 1.5 0.796 9 78.75 1 0       1 10 41636061, 40411682, 36428893, 36290981, 35247355, 28794177, 27836219, 22678933, 19261617, 15687383 1 Immunodeficiency due to a late component of complements deficiency 0.761965409699055
Q9UBT7 CTNNAL1 Alpha-catulin Tier 1.5 0.795 0 84.06 0 0       0 0   1 Abnormality of the skeletal system 0.31316995706583495
Q13705 ACVR2B Activin receptor type-2B Tier 1.5 0.791 9 83.31 1 0       0 0   0 Heterotaxia 0.7109733260300651
Q13085 ACACA Acetyl-CoA carboxylase 1 Tier 1.5 0.79 10 82.81 1 0       1 1 41854184 1    
Q96CS2 HAUS1 HAUS augmin-like complex subunit 1 Tier 1.5 0.79 1 88.62 1 0       0 0   0 device complication 0.27547205131467467
Q14031 COL4A6 Collagen alpha-6(IV) chain Tier 1.5 0.79 0 47.41 0 0       0 0   0 Dupuytren Contracture 0.5880367459451578
P36888 FLT3 Receptor-type tyrosine-protein kinase FLT3 Tier 1.5 0.788 11 75.94 0 0       1 6 41733039, 34364920, 31434881, 30237882, 29299123, 22411871 1 acute myeloid leukemia 0.8313389209288576
Q92633 LPAR1 Lysophosphatidic acid receptor 1 Tier 1.5 0.785 16 83.62 1 0       1 1 32065590 1 Epiretinal membrane 0.4757255248053499
P03971 AMH Anti-Muellerian hormone Tier 1.5 0.783 3 68.62 1 0       1 2 41101154, 27364573 0 persistent Mullerian duct syndrome 0.7847328444470535
Q5JUK3 KCNT1 Potassium channel subfamily T member 1 Tier 1.5 0.782 6 73.88 1 0       0 0   0 developmental and epileptic encephalopathy, 14 0.8165232785825526
P37023 ACVRL1 Activin receptor type-1-like Tier 1.5 0.779 7 82.0 0 0       0 0   0 telangiectasia, hereditary hemorrhagic, type 2 0.7951167515831324
P01568 IFNA21 Interferon alpha-21 Tier 1.5 0.777 0 85.0 0 0       0 0   0 renal cell carcinoma 0.3695798546847018
P30542 ADORA1 Adenosine receptor A1 Tier 1.5 0.777 5 92.44 1 0       0 0   0 asthma 0.7232344154541454
P13866 SLC5A1 Sodium/glucose cotransporter 1 Tier 1.5 0.777 4 84.38 1 0       0 0   0 glucose-galactose malabsorption 0.8220991027793896
P48023 FASLG Tumor necrosis factor ligand superfamily member 6 Tier 1.5 0.775 3 80.19 0 0       1 1 16581027 0 autoimmune lymphoproliferative syndrome type 1 0.6984292519156657
Q9BVX2 TMEM106C Transmembrane protein 106C Tier 1.5 0.77 0 80.81 0 0       0 0   0 prostate carcinoma 0.21737104399686757
P29017 CD1C T-cell surface glycoprotein CD1c Tier 1.5 0.77 10 88.56 0 0       0 0   0 neoplasm 0.1106047389635713
P02776 PF4 Platelet factor 4 Tier 1.5 0.77 10 75.06 0 0       1 10 33859620, 32366845, 31967847, 23847186, 23673861, 34248840, 32022468 1 systemic scleroderma 0.11523541376593864
P39060 COL18A1 Collagen alpha-1(XVIII) chain Tier 1.5 0.769 9 50.62 1 0       1 2 36707842, 23679916 1 Knobloch syndrome 1 0.7867122552672962
P27037 ACVR2A Activin receptor type-2A Tier 1.5 0.769 5 83.56 0 0       0 0   1 hepatocellular carcinoma 0.4908023126074436
P43004 SLC1A2 Excitatory amino acid transporter 2 Tier 1.5 0.768 7 77.75 1 0       0 0   0 developmental and epileptic encephalopathy, 41 0.7772658651722512
O14958 CASQ2 Calsequestrin-2 Tier 1.5 0.767 4 90.5 0 0       0 0   1 catecholaminergic polymorphic ventricular tachycardia 0.7718998507471558
Q9H3K6 BOLA2 BolA-like protein 2 Tier 1.5 0.765 0 92.69 0 0       0 0   1 hepatocellular carcinoma 0.08093942543094014
O60931 CTNS Cystinosin Tier 1.5 0.764 6 89.44 1 0       0 0   0 nephropathic cystinosis 0.841818398377195
A0A1B0GTW7 CIROP Ciliated left-right organizer metallopeptidase Tier 1.5 0.764 0 73.44 0 0       0 0   0 heterotaxy, visceral, 12, autosomal 0.6929422132808513
O60568 PLOD3 Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 Tier 1.5 0.762 18 91.38 1 0       0 0   1 bone fragility with contractures, arterial rupture, and deafness 0.7159150369336311
Q9Y5Y9 SCN10A Sodium channel protein type 10 subunit alpha Tier 1.5 0.761 8 67.31 1 0       0 0   0 atrial fibrillation 0.7126293968222049
Q9BZR8 BCL2L14 Apoptosis facilitator Bcl-2-like protein 14 Tier 1.5 0.76 0 62.38 0 0       0 0   0 hypothyroidism 0.33117514363294837
Q9BWF2 TRAIP E3 ubiquitin-protein ligase TRAIP Tier 1.5 0.76 1 74.94 0 0       0 0   0 Seckel syndrome 9 0.683878095944948
O15370 SOX12 Transcription factor SOX-12 Tier 1.5 0.76 0 63.0 0 0       0 0   0 type 2 diabetes mellitus 0.3277369133971199
O15552 FFAR2 Free fatty acid receptor 2 Tier 1.5 0.759 11 88.06 1 0       0 0   0 type 1 diabetes mellitus 0.09182737097469269
A6NI61 MYMK Protein myomaker Tier 1.5 0.758 0 90.44 0 0       0 0   0 Carey-Fineman-Ziter syndrome 0.7790386256350393
P35462 DRD3 D(3) dopamine receptor Tier 1.5 0.757 6 75.38 1 0       0 0   0 schizophrenia 0.6687268941647396

Next page

Advanced export

JSON shape: default, array, newline-delimited

CSV options: 

CREATE VIEW v_targets AS
SELECT f.id, n.gene_symbol, n.protein_name, tg.tier, f.priority_score,
 f.pdb_count_total, f.alphafold_mean_pLDDT, f.has_cryoEM,
 f.has_activation_state_pdb_pair, f.activation_state_pdb_active, f.activation_state_pdb_inactive,
 f.drug_count_approved, f.has_known_aptamer, f.aptamer_count_pubmed, ap.aptamer_pmids,
 f.in_cev_map, f.opentargets_top_disease_name, f.opentargets_top_disease_score
FROM v_target_full f
LEFT JOIN target_names n ON n.target_id=f.id
LEFT JOIN targets tg ON tg.id=f.id
LEFT JOIN target_aptamer_pmids ap ON ap.target_id=f.id;