EV-Map conserved proteome (Rai & Greening 2025)

The complete EV-Map conserved molecular signature (Rai & Greening 2025, Nat Cell Biol 10.1038/s41556-025-01795-7): 182 conserved EV-hallmark proteins + 42 non-EV (lipoprotein-network) proteins. in_apt_scout = 1 if the protein is an apt-scout target (104 of the 182 EV-hallmark + 25 of the 42 non-EV are; the rest are reference-only, outside apt-scout's target universe). Source: paper Supplementary Table 7.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

gene_name
Gene symbol.
feature
EV-hallmark (conserved EV) or non-EV (lipoprotein-network).
category
EV-Map conservation category (1/2/3/Rest).
in_apt_scout
1 if this protein is an apt-scout target.
apt_scout_uniprot
apt-scout target UniProt (if in_apt_scout=1).

210 rows where category = "Category 1"

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in_apt_scout 2

  • 1 119
  • 0 91

feature 2

category 1

  • Category 1 · 210 ✖
Link rowid ▼ gene_name feature category misev_marker entrezgene_id pevs_median in_apt_scout apt_scout_uniprot
1 1 YWHAZ EV-hallmark Category 1   7534 28.45468418 1 P63104
2 2 YWHAH EV-hallmark Category 1   7533 25.13893447 1 Q04917
3 3 YWHAE EV-hallmark Category 1   7531 25.27100806 1 P62258
4 4 WDR1 EV-hallmark Category 1   9948 26.19839833 0  
5 5 VWF EV-hallmark Category 1   7450 28.62903915 0  
6 6 VCP EV-hallmark Category 1   7415 25.33415684 1 P55072
7 7 VCL EV-hallmark Category 1   7414 28.01670384 1 P18206
8 8 VASP EV-hallmark Category 1   7408 24.67483149 1 P50552
9 9 TXN EV-hallmark Category 1   7295 23.66868868 1 P10599
10 10 TUBB1 EV-hallmark Category 1   81027 27.9398276 1 Q9H4B7
11 11 TUBA4A EV-hallmark Category 1   7277 26.54836852 0  
12 12 TTR non-EV Category 1   7276 26.75396118 1 P02766
13 13 TLN1 EV-hallmark Category 1   7094 29.75297537 0  
14 14 THBS1 EV-hallmark Category 1   7057 28.68547501 1 P07996
15 15 TFRC EV-hallmark Category 1   7037 26.00470107 1 P02786
16 16 TF non-EV Category 1   7018 30.26195856 1 P02787
17 17 TAGLN2 EV-hallmark Category 1   8407 25.91603631 1 P37802
18 18 STXBP2 EV-hallmark Category 1   6813 25.41292757 1 Q15833
19 19 STX7 EV-hallmark Category 1   8417 24.21802859 1 O15400
20 20 STOM EV-hallmark Category 1   2040 29.05092815 0  
21 21 STEAP3 EV-hallmark Category 1   55240 23.91589282 1 Q658P3
22 22 SRC EV-hallmark Category 1   6714 24.88760814 1 P12931
23 23 SPTA1 EV-hallmark Category 1   6708 25.81147463 1 P02549
24 24 SOD2 EV-hallmark Category 1   6648 25.1545267 1 P04179
25 25 SNAP23 EV-hallmark Category 1   8773 23.74082625 1 O00161
26 26 SLC4A1 EV-hallmark Category 1   6521 29.41994604 1 P02730
27 27 SLC44A1 EV-hallmark Category 1   23446 23.57973465 0  
28 28 SLC2A3 EV-hallmark Category 1   6515 25.62146728 1 P11169
29 29 SLC2A1 EV-hallmark Category 1   6513 26.64195033 1 P11166
30 30 SERPING1 non-EV Category 1   710 25.77602287 0  
31 31 SERPINF2 non-EV Category 1   5345 24.95654127 0  
33 33 SERPIND1 non-EV Category 1   3053 24.498994 1 P05546
34 34 SERPINC1 non-EV Category 1   462 26.43978997 1 P01008
35 35 SERPINB1 EV-hallmark Category 1   1992 24.26587588 0  
37 37 SERPINA3 non-EV Category 1   12 25.78024806 1 P01011
38 38 SDCBP EV-hallmark Category 1   6386 23.05441285 1 O00560
39 39 S100A9 EV-hallmark Category 1   6280 24.30169775 1 P06702
40 40 S100A8 EV-hallmark Category 1   6279 23.74222506 1 P05109
41 41 RSU1 EV-hallmark Category 1   6251 26.07493689 1 Q15404
42 42 RPS27A EV-hallmark Category 1   6233 25.79577986 1 P62979
43 43 RHOA EV-hallmark Category 1   387 24.33077011 1 P61586
44 44 RBP4 non-EV Category 1   5950 22.88201127 1 P02753
45 45 RAP1B EV-hallmark Category 1   5908 28.4733278 1 P61224
46 46 RAN EV-hallmark Category 1   5901 22.8753578 1 P62826
47 47 RAC1 EV-hallmark Category 1   5879 25.37625276 1 P63000
48 48 RAB7A EV-hallmark Category 1   7879 24.56787254 0  
49 49 RAB27B EV-hallmark Category 1   5874 25.03630892 1 O00194
50 50 RAB10 EV-hallmark Category 1   10890 24.88729904 0  
51 51 PTPRJ EV-hallmark Category 1   5795 24.26575206 1 Q12913
52 52 PTPRC EV-hallmark Category 1   5788 23.56840014 1 P08575

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CREATE TABLE ev_map_conserved (gene_name TEXT, feature TEXT, category TEXT,
             misev_marker TEXT, entrezgene_id TEXT, pevs_median TEXT,
             in_apt_scout INTEGER, apt_scout_uniprot TEXT);