EV-Map conserved proteome (Rai & Greening 2025)

The complete EV-Map conserved molecular signature (Rai & Greening 2025, Nat Cell Biol 10.1038/s41556-025-01795-7): 182 conserved EV-hallmark proteins + 42 non-EV (lipoprotein-network) proteins. in_apt_scout = 1 if the protein is an apt-scout target (104 of the 182 EV-hallmark + 25 of the 42 non-EV are; the rest are reference-only, outside apt-scout's target universe). Source: paper Supplementary Table 7.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

gene_name
Gene symbol.
feature
EV-hallmark (conserved EV) or non-EV (lipoprotein-network).
category
EV-Map conservation category (1/2/3/Rest).
in_apt_scout
1 if this protein is an apt-scout target.
apt_scout_uniprot
apt-scout target UniProt (if in_apt_scout=1).

42 rows where feature = "non-EV"

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category 4

in_apt_scout 2

  • 1 25
  • 0 17

feature 1

  • non-EV · 42 ✖
Link rowid ▼ gene_name feature category misev_marker entrezgene_id pevs_median in_apt_scout apt_scout_uniprot
12 12 TTR non-EV Category 1   7276 26.75396118 1 P02766
16 16 TF non-EV Category 1   7018 30.26195856 1 P02787
30 30 SERPING1 non-EV Category 1   710 25.77602287 0  
31 31 SERPINF2 non-EV Category 1   5345 24.95654127 0  
32 32 SERPINF1 non-EV Rest   5176 22.03354595 1 P36955
33 33 SERPIND1 non-EV Category 1   3053 24.498994 1 P05546
34 34 SERPINC1 non-EV Category 1   462 26.43978997 1 P01008
36 36 SERPINA4 non-EV Category 2   5267 23.04960691 1 P29622
37 37 SERPINA3 non-EV Category 1   12 25.78024806 1 P01011
44 44 RBP4 non-EV Category 1   5950 22.88201127 1 P02753
62 62 PON1 non-EV Category 1   5444 25.26189032 0  
66 66 PGLYRP2 non-EV Category 1   114770 24.04629121 1 Q96PD5
75 75 ORM1 non-EV Category 1   5004 25.26127749 0  
87 87 LUM non-EV Rest   4060 22.41106809 1 P51884
92 92 KNG1 non-EV Category 1   3827 26.91520432 1 P01042
94 94 ITIH3 non-EV Category 3   3699 21.59465937 0  
95 95 ITIH2 non-EV Category 1   3698 27.50080873 0  
96 96 ITIH1 non-EV Category 1   3697 26.99493599 1 P19827
130 130 IGHG4 non-EV Category 1     28.24915617 0  
131 131 IGFALS non-EV Category 2   3483 23.25044831 1 P35858
136 136 HPX non-EV Category 1   3263 27.09408196 0  
140 140 HABP2 non-EV Category 3   3026 22.19217062 1 Q14520
146 146 GC non-EV Category 1   2638 26.02859389 1 P02774
158 158 FBLN1 non-EV Rest   2192 21.85894765 0  
160 160 F2 non-EV Category 1   2147 25.48847607 0  
161 161 F13B non-EV Rest   2165 22.01963417 0  
164 164 F10 non-EV Rest   2159 22.10768229 1 P00742
170 170 CPB2 non-EV Rest   1361 22.13340968 1 Q96IY4
174 174 CLEC3B non-EV Rest   7123 22.20646531 1 P05452
176 176 CFI non-EV Category 1   3426 23.0706348 0  
188 188 C9 non-EV Category 1   735 24.25962094 1 P02748
189 189 C7 non-EV Category 1   730 23.59117526 1 P10643
190 190 C6 non-EV Category 1   729 23.1444777 1 P13671
196 196 AZGP1 non-EV Category 1   563 24.56888932 1 P25311
197 197 ATRN non-EV Category 3   8455 23.14435738 1 O75882
207 207 APOH non-EV Category 1   350 26.40648294 1 P02749
208 208 APOB non-EV Category 1   338 27.32785537 0  
209 209 APOA4 non-EV Category 1   337 25.8536907 0  
215 215 AMBP non-EV Category 1   259 26.03843225 0  
217 217 AHSG non-EV Category 1   197 25.54351737 0  
218 218 AFM non-EV Category 2   173 23.86740073 1 P43652
224 224 A1BG non-EV Category 2   1 25.43002533 0  

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CREATE TABLE ev_map_conserved (gene_name TEXT, feature TEXT, category TEXT,
             misev_marker TEXT, entrezgene_id TEXT, pevs_median TEXT,
             in_apt_scout INTEGER, apt_scout_uniprot TEXT);