EV-Map conserved proteome (Rai & Greening 2025)

The complete EV-Map conserved molecular signature (Rai & Greening 2025, Nat Cell Biol 10.1038/s41556-025-01795-7): 182 conserved EV-hallmark proteins + 42 non-EV (lipoprotein-network) proteins. in_apt_scout = 1 if the protein is an apt-scout target (104 of the 182 EV-hallmark + 25 of the 42 non-EV are; the rest are reference-only, outside apt-scout's target universe). Source: paper Supplementary Table 7.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

gene_name
Gene symbol.
feature
EV-hallmark (conserved EV) or non-EV (lipoprotein-network).
category
EV-Map conservation category (1/2/3/Rest).
in_apt_scout
1 if this protein is an apt-scout target.
apt_scout_uniprot
apt-scout target UniProt (if in_apt_scout=1).

95 rows where in_apt_scout = 0

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category 4

feature 2

in_apt_scout 1

Link rowid ▼ gene_name feature category misev_marker entrezgene_id pevs_median in_apt_scout apt_scout_uniprot
4 4 WDR1 EV-hallmark Category 1   9948 26.19839833 0  
5 5 VWF EV-hallmark Category 1   7450 28.62903915 0  
11 11 TUBA4A EV-hallmark Category 1   7277 26.54836852 0  
13 13 TLN1 EV-hallmark Category 1   7094 29.75297537 0  
20 20 STOM EV-hallmark Category 1   2040 29.05092815 0  
27 27 SLC44A1 EV-hallmark Category 1   23446 23.57973465 0  
30 30 SERPING1 non-EV Category 1   710 25.77602287 0  
31 31 SERPINF2 non-EV Category 1   5345 24.95654127 0  
35 35 SERPINB1 EV-hallmark Category 1   1992 24.26587588 0  
48 48 RAB7A EV-hallmark Category 1   7879 24.56787254 0  
50 50 RAB10 EV-hallmark Category 1   10890 24.88729904 0  
57 57 PRKAR1A EV-hallmark Category 1   5573 23.67367497 0  
58 58 PRDX6 EV-hallmark Category 1   9588 25.31893571 0  
62 62 PON1 non-EV Category 1   5444 25.26189032 0  
63 63 PLEK EV-hallmark Category 1   5341 26.33307833 0  
70 70 PFKL EV-hallmark Category 1   5211 22.85982864 0  
71 71 PECAM1 EV-hallmark Category 1   5175 26.38277561 0  
74 74 P2RX1 EV-hallmark Category 1   5023 22.6323641 0  
75 75 ORM1 non-EV Category 1   5004 25.26127749 0  
76 76 NCKAP1 EV-hallmark Category 1   10787 23.38914712 0  
78 78 MYL9 EV-hallmark Category 1   10398 26.67317895 0  
79 79 MYH9 EV-hallmark Category 1   4627 30.16395959 0  
81 81 MPP1 EV-hallmark Category 1   4354 23.58635779 0  
83 83 MFGE8 EV-hallmark Category 1   4240 23.56109455 0  
90 90 LGALS3BP EV-hallmark Category 1   3959 29.77691943 0  
93 93 JCHAIN EV-hallmark Category 1   3512 32.11090531 0  
94 94 ITIH3 non-EV Category 3   3699 21.59465937 0  
95 95 ITIH2 non-EV Category 1   3698 27.50080873 0  
99 99 ITGA6 EV-hallmark Category 1   3655 26.44235276 0  
102 102 ILK EV-hallmark Category 1   3611 26.56276322 0  
103 103 IGLV5-45 EV-hallmark Category 1     25.89979351 0  
104 104 IGLV2-8 EV-hallmark Category 1     27.79209306 0  
105 105 IGLV2-18 EV-hallmark Category 1     25.43844265 0  
106 106 IGLV2-11 EV-hallmark Category 1     25.59109932 0  
107 107 IGLV1-51 EV-hallmark Category 1     28.838624 0  
108 108 IGLV1-47 EV-hallmark Category 1     29.89989078 0  
109 109 IGLV1-40 EV-hallmark Category 1     26.75666483 0  
110 110 IGKV6-21 EV-hallmark Category 1     26.08028323 0  
112 112 IGKV3-20 EV-hallmark Category 1     30.77484518 0  
113 113 IGKV2-24 EV-hallmark Category 1     29.20421913 0  
114 114 IGKV1-8 EV-hallmark Category 1     25.00827838 0  
115 115 IGKV1-5 EV-hallmark Category 1     27.45159932 0  
116 116 IGKV1-17 EV-hallmark Category 1     28.27933341 0  
117 117 IGKV1-16 EV-hallmark Category 1     26.95698195 0  
118 118 IGHV6-1 EV-hallmark Category 1     27.14053387 0  
119 119 IGHV5-51 EV-hallmark Category 1     28.4979294 0  
120 120 IGHV4-34 EV-hallmark Category 1     25.8094622 0  
121 121 IGHV3-74 EV-hallmark Category 1     27.85771721 0  
122 122 IGHV3-72 EV-hallmark Category 1     27.63860588 0  
123 123 IGHV3-43D EV-hallmark Category 1     27.07545999 0  

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CREATE TABLE ev_map_conserved (gene_name TEXT, feature TEXT, category TEXT,
             misev_marker TEXT, entrezgene_id TEXT, pevs_median TEXT,
             in_apt_scout INTEGER, apt_scout_uniprot TEXT);