EV-surface aptamer candidates (surface ecto × EV-Map hallmark), ranked

Cell-surface ecto proteins that are ALSO EV-Map conserved EV-hallmark proteins — the top set of targets reachable by an aptamer on an intact circulating EV. Ranked by targetability_score.

Custom SQL query returning 24 rows (hide) 

SELECT gene_symbol, protein_name, surface_class, targetability_score, pdb_count, top_disease, disease_score, surface_evidence FROM v_surface_targets WHERE surface_class='A_surface' AND ev_map_hallmark=1 ORDER BY targetability_score DESC

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gene_symbolprotein_namesurface_classtargetability_scorepdb_counttop_diseasedisease_scoresurface_evidence
SLC2A1 Solute carrier family 2, facilitated glucose transporter member 1 A_surface 2.756 5 encephalopathy due to GLUT1 deficiency 0.8521823225896756 HPA integral membrane protein, Plasma membrane (extracellular domain reachable)
GP1BA Platelet glycoprotein Ib alpha chain A_surface 2.75 22 Bernard-Soulier syndrome 0.8346884735388165 HPA protein class = CD markers (cell-surface, extracellular epitope)
ITGA2B Integrin alpha-IIb A_surface 2.747 78 Glanzmann thrombasthenia 1 0.8224288672248264 HPA protein class = CD markers (cell-surface, extracellular epitope)
GP9 Platelet glycoprotein IX A_surface 2.747 2 Bernard-Soulier syndrome 0.8233582238860002 HPA protein class = CD markers (cell-surface, extracellular epitope)
SLC4A1 Band 3 anion transport protein A_surface 2.746 54 hereditary spherocytosis type 4 0.820137113225454 HPA protein class = Blood group antigen proteins, CD markers (cell-surface, extracellular epitope)
ITGB3 Integrin beta-3 A_surface 2.746 123 Glanzmann thrombasthenia 1 0.8208115968652424 HPA protein class = CD markers (cell-surface, extracellular epitope)
CD36 Platelet glycoprotein 4 A_surface 2.721 1 platelet-type bleeding disorder 10 0.7360571429413174 HPA protein class = CD markers (cell-surface, extracellular epitope)
PTPRC Receptor-type tyrosine-protein phosphatase C A_surface 2.716 6 immunodeficiency 104 0.7200430416648742 HPA protein class = CD markers (cell-surface, extracellular epitope)
TFRC Transferrin receptor protein 1 A_surface 2.687 22 TFRC-related combined immunodeficiency 0.623449899069336 HPA protein class = CD markers (cell-surface, extracellular epitope)
ITGB1 Integrin beta-1 A_surface 2.676 22 multiple sclerosis 0.586769452063963 HPA protein class = CD markers (cell-surface, extracellular epitope)
IGHV3-23 Immunoglobulin heavy variable 3-23 A_surface 2.676 6 cutaneous Leishmaniasis 0.5868213846274001 HPA protein class = Immunoglobulin genes (cell-surface, extracellular epitope)
IGHV1-2 Immunoglobulin heavy variable 1-2 A_surface 2.676 1 cutaneous Leishmaniasis 0.5868213846274001 HPA protein class = Immunoglobulin genes (cell-surface, extracellular epitope)
IGKV4-1 Immunoglobulin kappa variable 4-1 A_surface 2.676 10 cutaneous Leishmaniasis 0.5868213846274001 HPA protein class = Immunoglobulin genes (cell-surface, extracellular epitope)
PTPRJ Receptor-type tyrosine-protein phosphatase eta A_surface 2.664 5 neurodegenerative disease 0.54699134609967 HPA protein class = CD markers (cell-surface, extracellular epitope)
SNAP23 Synaptosomal-associated protein 23 A_surface 2.659 2 neurodegenerative disease 0.5288361677964304 HPA integral membrane protein, Plasma membrane (extracellular domain reachable)
CD9 CD9 antigen A_surface 2.658 5 diphtheria 0.5261379875719714 HPA protein class = CD markers (cell-surface, extracellular epitope)
ANPEP Aminopeptidase N A_surface 2.651 15 cholelithiasis 0.5030146927270738 HPA protein class = CD markers (cell-surface, extracellular epitope)
IGHM Immunoglobulin heavy constant mu A_surface 2.639 30 agammaglobulinemia 0.4624778576025314 HPA protein class = Immunoglobulin genes (cell-surface, extracellular epitope)
PIGR Polymeric immunoglobulin receptor A_surface 2.633 16 clear cell renal carcinoma 0.44260204134234277 HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)
ITGA2 Integrin alpha-2 A_surface 2.627 16 Abnormality of the skeletal system 0.4227839911251069 HPA protein class = CD markers (cell-surface, extracellular epitope)
SLC2A3 Solute carrier family 2, facilitated glucose transporter member 3 A_surface 2.622 7 neurodegenerative disease 0.4054698468991856 HPA integral membrane protein, Plasma membrane (extracellular domain reachable)
CD47 Leukocyte surface antigen CD47 A_surface 2.61 15 myelodysplastic syndrome 0.3682348506170252 HPA protein class = CD markers (cell-surface, extracellular epitope)
PARVB Beta-parvin A_surface 2.584 3 thyroiditis 0.28021156500366357 HPA integral membrane protein, Plasma membrane (extracellular domain reachable)
C1QB Complement C1q subcomponent subunit B A_surface 2.5 11     HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)