kd_measurements: 31
This data as json
| id | source_pmid | aptamer_name | target_name_canonical | target_uniprot | kd_value | kd_unit | kd_log10_molar | binding_constant_type | aptamer_chemistry | aptamer_modifications | assay_method | assay_buffer | assay_ph | assay_temperature_k | assay_cations | verification_status | source_db | source_record_id | aptamer_seq | aptamer_seq_raw | measurement_class | verbatim_quote | seq_source | tier | sequence_status | pi_provenance_flag | include_in_gold | doi |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 31 | 19422452 | ARC1779 | VWF A1-domain | P04275 | 2.0 | nM | -8.699 | Kd | DNA/RNA | 2'-O-methyl; phosphorothioate; inverted deoxythymidine; 20-kDa PEG conjugation | filter_binding | Dulbecco's PBS containing 0.1 mg mL-1 BSA | 298.15 | verified | step2c_literal_v3 | r00088 | intrinsic | This resulted in a final aptamer (ARC1779) that is a 40-nucleotide modified DNA/RNA oligonucleotide with a K D of 2 nM for the A1-domain. | v4 | pending_manual_figure | True | 10.1111/j.1538-7836.2009.03459.x |