Top-priority targets

Top 100 targets by apt-scout composite priority score.

Custom SQL query returning 100 rows (hide) 

SELECT id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, has_activation_state_pdb_pair, has_known_aptamer, opentargets_top_disease_name FROM v_targets ORDER BY priority_score DESC LIMIT 100

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idgene_symbolprotein_nametierpriority_scorepdb_count_totalhas_activation_state_pdb_pairhas_known_aptameropentargets_top_disease_name
P25445 FAS Tumor necrosis factor receptor superfamily member 6 Tier 1.5 0.914 7 0 1 autoimmune lymphoproliferative syndrome type 1
P12263     Tier 1 0.9 7 0 0  
Q12879 GRIN2A Glutamate receptor ionotropic, NMDA 2A Tier 1 0.88 37 0 0 Landau-Kleffner syndrome
Q9Y2C5 SLC17A4 Probable small intestine urate exporter Tier 1.5 0.878 0 0 0 inflammatory bowel disease
P23946 CMA1 Chymase Tier 1 0.875 42 0 1 pernicious anemia
Q9UJA9 ENPP5 Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 Tier 1 0.87 1 0 0 neurodegenerative disease
O75581 LRP6 Low-density lipoprotein receptor-related protein 6 Tier 1 0.865 27 0 1 tooth agenesis, selective, 7
P13747 HLA-E HLA class I histocompatibility antigen, alpha chain E Tier 1 0.865 34 0 1 COVID-19
Q9NX14 NDUFB11 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial Tier 1.5 0.86 0 0 0 Microphthalmia with linear skin defects syndrome
P21583 KITLG Kit ligand Tier 1.5 0.848 6 0 1 hyperpigmentation with or without hypopigmentation, familial progressive
P35346 SSTR5 Somatostatin receptor type 5 Tier 1.5 0.841 7 0 0 acromegaly
Q02094 RHAG Ammonium transporter Rh type A Tier 1.5 0.841 8 0 0 Rh deficiency syndrome
P01911 HLA-DRB1 HLA class II histocompatibility antigen, DRB1 beta chain Tier 1 0.84 100 0 0 rheumatoid arthritis
Q5T848 GPR158 Metabotropic glycine receptor Tier 1 0.839 6 0 0 diverticular disease
Q14392 LRRC32 Transforming growth factor beta activator LRRC32 Tier 1.5 0.838 6 0 0 cleft palate, proliferative retinopathy, and developmental delay
P21439 ABCB4 Phosphatidylcholine translocator ABCB4 Tier 1.5 0.835 4 0 0 progressive familial intrahepatic cholestasis type 3
P12532 CKMT1A Creatine kinase U-type, mitochondrial Tier 1.5 0.83 9 0 0 neurodegenerative disease
Q31135 H2-Ab1   Tier 1 0.83 12 0 0  
P0DSE2 TRB M1-specific T cell receptor beta chain Tier 1 0.83 5 0 0  
O75899 GABBR2 Gamma-aminobutyric acid type B receptor subunit 2 Tier 1.5 0.824 26 0 0 developmental and epileptic encephalopathy, 59
A0A0E3EAY4 env Envelope glycoprotein gp160 Tier 1 0.82 2 0 1  
P54709 ATP1B3 Sodium/potassium-transporting ATPase subunit beta-3 Tier 1.5 0.81 7 0 0 congestive heart failure
Q00975 CACNA1B Voltage-dependent N-type calcium channel subunit alpha-1B Tier 1.5 0.807 7 0 1 Seizure
Q15848 ADIPOQ Adiponectin Tier 1 0.806 3 0 1 hearing loss
P0DPK4 NOTCH2NLC Notch homolog 2 N-terminal-like protein C Tier 1.5 0.805 0 0 0 neuronal intranuclear inclusion disease
P43005 SLC1A1 Excitatory amino acid transporter 3 Tier 1 0.805 22 0 0 dicarboxylic aminoaciduria
P15260 IFNGR1 Interferon gamma receptor 1 Tier 1.5 0.804 5 0 1 disseminated atypical mycobacterial infection
P51679 CCR4 C-C chemokine receptor type 4 Tier 1 0.804 7 0 1 mycosis fungoides
Q9NS82 SLC7A10 Asc-type amino acid transporter 1 Tier 1 0.803 4 0 0 asthma
Q04844 CHRNE Acetylcholine receptor subunit epsilon Tier 1.5 0.802 13 0 0 Congenital myasthenic syndromes
O60895 RAMP2 Receptor activity-modifying protein 2 Tier 1 0.802 10 0 0 diabetes mellitus
P29275 ADORA2B Adenosine receptor A2b Tier 1.5 0.801 4 0 0 migraine disorder
Q9H2X9 SLC12A5 Solute carrier family 12 member 5 Tier 1.5 0.8 2 0 0 genetic developmental and epileptic encephalopathy
P35414 APLNR Apelin receptor Tier 1 0.8 37 0 1 essential hypertension
P00488 F13A1 Coagulation factor XIII A chain Tier 1 0.799 15 0 0 Factor XIII subunit A deficiency
P02748 C9 Complement component C9 Tier 1.5 0.796 9 0 1 Immunodeficiency due to a late component of complements deficiency
Q9UBT7 CTNNAL1 Alpha-catulin Tier 1.5 0.795 0 0 0 Abnormality of the skeletal system
P13671 C6 Complement component C6 Tier 1 0.795 11 0 1 Immunodeficiency due to a late component of complements deficiency
P01236 PRL Prolactin Tier 1 0.795 12 0 1 AL amyloidosis
P06731 CEACAM5 Cell adhesion molecule CEACAM5 Tier 1 0.795 6 0 0 neurodegenerative disease
P01909 HLA-DQA1 HLA class II histocompatibility antigen, DQ alpha 1 chain Tier 1 0.792 27 0 0 Pleural Mesothelioma
Q13705 ACVR2B Activin receptor type-2B Tier 1.5 0.791 9 0 0 Heterotaxia
Q13085 ACACA Acetyl-CoA carboxylase 1 Tier 1.5 0.79 10 0 1  
Q96CS2 HAUS1 HAUS augmin-like complex subunit 1 Tier 1.5 0.79 1 0 0 device complication
Q14031 COL4A6 Collagen alpha-6(IV) chain Tier 1.5 0.79 0 0 0 Dupuytren Contracture
O14788 TNFSF11 Tumor necrosis factor ligand superfamily member 11 Tier 1 0.79 2 0 1 osteoporosis
P36888 FLT3 Receptor-type tyrosine-protein kinase FLT3 Tier 1.5 0.788 11 0 1 acute myeloid leukemia
Q92633 LPAR1 Lysophosphatidic acid receptor 1 Tier 1.5 0.785 16 0 1 Epiretinal membrane
P04156 PRNP Major prion protein Tier 1 0.785 70 0 1 Gerstmann-Straussler-Scheinker syndrome
P03971 AMH Anti-Muellerian hormone Tier 1.5 0.783 3 0 1 persistent Mullerian duct syndrome
Q5JUK3 KCNT1 Potassium channel subfamily T member 1 Tier 1.5 0.782 6 0 0 developmental and epileptic encephalopathy, 14
Q13639     Tier 1 0.781 3 0 0 schizophrenia
P35555 FBN1 Fibrillin-1 Tier 1 0.78 11 0 0 Marfan syndrome
P14210 HGF Hepatocyte growth factor Tier 1 0.78 36 0 1 hearing loss, autosomal recessive
P37023 ACVRL1 Activin receptor type-1-like Tier 1.5 0.779 7 0 0 telangiectasia, hereditary hemorrhagic, type 2
P01019 AGT Angiotensinogen Tier 1 0.779 22 0 1 renal tubular dysgenesis
P01568 IFNA21 Interferon alpha-21 Tier 1.5 0.777 0 0 0 renal cell carcinoma
P30542 ADORA1 Adenosine receptor A1 Tier 1.5 0.777 5 0 0 asthma
P13866 SLC5A1 Sodium/glucose cotransporter 1 Tier 1.5 0.777 4 0 0 glucose-galactose malabsorption
P04839 CYBB NADPH oxidase 2 Tier 1 0.776 6 0 1 chronic granulomatous disease
P48023 FASLG Tumor necrosis factor ligand superfamily member 6 Tier 1.5 0.775 3 0 1 autoimmune lymphoproliferative syndrome type 1
O15393     Tier 1 0.775 31 0 0 COVID-19
P07911 UMOD Uromodulin Tier 1 0.774 10 0 1 familial juvenile hyperuricemic nephropathy type 1
A6ND01 IZUMO1R Sperm-egg fusion protein Juno Tier 1 0.773 7 0 0 placental retention
Q9BVX2 TMEM106C Transmembrane protein 106C Tier 1.5 0.77 0 0 0 prostate carcinoma
P29017 CD1C T-cell surface glycoprotein CD1c Tier 1.5 0.77 10 0 0 neoplasm
P02776 PF4 Platelet factor 4 Tier 1.5 0.77 10 0 1 systemic scleroderma
P02671 FGA Fibrinogen alpha chain Tier 1 0.77 40 0 0 familial dysfibrinogenemia
A0A5H2UYS3 HLA-A   Tier 1 0.77 20 0 0  
P03951 F11 Coagulation factor XI Tier 1 0.77 100 0 0 factor XI deficiency
P61769 B2M Beta-2-microglobulin Tier 1 0.77 100 0 1 Immunodeficiency by defective expression of HLA class 1
P39060 COL18A1 Collagen alpha-1(XVIII) chain Tier 1.5 0.769 9 0 1 Knobloch syndrome 1
P27037 ACVR2A Activin receptor type-2A Tier 1.5 0.769 5 0 0 hepatocellular carcinoma
P29460 IL12B Interleukin-12 subunit beta Tier 1 0.769 20 0 0 psoriasis
P43004 SLC1A2 Excitatory amino acid transporter 2 Tier 1.5 0.768 7 0 0 developmental and epileptic encephalopathy, 41
O14958 CASQ2 Calsequestrin-2 Tier 1.5 0.767 4 0 0 catecholaminergic polymorphic ventricular tachycardia
P26951 IL3RA Interleukin-3 receptor subunit alpha Tier 1 0.767 4 0 1 acute myeloid leukemia
Q9H3K6 BOLA2 BolA-like protein 2 Tier 1.5 0.765 0 0 0 hepatocellular carcinoma
O60931 CTNS Cystinosin Tier 1.5 0.764 6 0 0 nephropathic cystinosis
A0A1B0GTW7 CIROP Ciliated left-right organizer metallopeptidase Tier 1.5 0.764 0 0 0 heterotaxy, visceral, 12, autosomal
O60568 PLOD3 Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 Tier 1.5 0.762 18 0 0 bone fragility with contractures, arterial rupture, and deafness
P02747 C1QC Complement C1q subcomponent subunit C Tier 1 0.762 11 0 0 C1Q deficiency
Q9Y5Y9 SCN10A Sodium channel protein type 10 subunit alpha Tier 1.5 0.761 8 0 0 atrial fibrillation
P98073     Tier 1 0.761 14 0 0 congenital enteropathy due to enteropeptidase deficiency
Q9BZR8 BCL2L14 Apoptosis facilitator Bcl-2-like protein 14 Tier 1.5 0.76 0 0 0 hypothyroidism
Q9BWF2 TRAIP E3 ubiquitin-protein ligase TRAIP Tier 1.5 0.76 1 0 0 Seckel syndrome 9
O15370 SOX12 Transcription factor SOX-12 Tier 1.5 0.76 0 0 0 type 2 diabetes mellitus
Q02817 MUC2 Mucin-2 Tier 1 0.76 12 0 0  
P01189 POMC Pro-opiomelanocortin Tier 1 0.76 13 0 1 obesity due to pro-opiomelanocortin deficiency
P40225 THPO Thrombopoietin Tier 1 0.76 3 0 1 thrombocythemia 1
O75762 TRPA1 Transient receptor potential cation channel subfamily A member 1 Tier 1 0.76 17 0 0 familial episodic pain syndrome with predominantly upper body involvement
O15552 FFAR2 Free fatty acid receptor 2 Tier 1.5 0.759 11 0 0 type 1 diabetes mellitus
A6NI61 MYMK Protein myomaker Tier 1.5 0.758 0 0 0 Carey-Fineman-Ziter syndrome
P35462 DRD3 D(3) dopamine receptor Tier 1.5 0.757 6 0 0 schizophrenia
P41440 SLC19A1 Reduced folate transporter Tier 1.5 0.755 19 0 0 Knobloch syndrome
P07360     Tier 1 0.755 15 0 0 complement deficiency
O00591 GABRP Gamma-aminobutyric acid receptor subunit pi Tier 1.5 0.752 2 0 0 migraine disorder
P05546 SERPIND1 Heparin cofactor 2 Tier 1 0.752 9 0 1 heparin cofactor 2 deficiency
P55899 FCGRT IgG receptor FcRn large subunit p51 Tier 1 0.752 31 0 0 Myasthenia gravis
P0DMS8 ADORA3 Adenosine receptor A3 Tier 1.5 0.751 5 0 0 migraine disorder