Targets — browse / sort / filter (view)

One row per human protein target with names + key evidence. Click column headers to SORT; use the facets to FILTER (tier, activation pair, known aptamer, EV-Map). UniProt IDs link to the source.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

id
UniProt accession (human). Links to uniprot.org.
gene_symbol
Gene symbol (e.g. ITGB3).
protein_name
Protein name (UniProt).
tier
Tier 1 = PDB-anchored; Tier 1.5 = AlphaFold-confident.
priority_score
Composite prioritisation = 0.30*biology + 0.30*reagent-gap + 0.20*druggability + 0.10*disease + 0.10*novelty. Sub-scores are assigned during LLM-assisted curation — a heuristic ranking, NOT an experimental measurement.
has_activation_state_pdb_pair
1 if a curated ACTIVE/INACTIVE PDB pair exists (only 11 targets).
in_cev_map
1 if in the EV-Map circulating-EV proteome (Rai 2025); 3,422 targets.
has_known_aptamer
1 if aptamer evidence found in PubMed/Aptagen (1,472 targets).
opentargets_top_disease_score
Open Targets association score (0-1).
aptamer_count_pubmed
Number of PubMed hits for this protein AND (aptamer OR SELEX).
aptamer_pmids
The actual PubMed IDs behind the aptamer evidence — click each to read the paper. This is the source of the 'has aptamer' claim.

3,374 rows where has_cryoEM = 0 and tier = "Tier 1.5" sorted by priority_score descending

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Suggested facets: pdb_count_total

in_cev_map 2

  • 0 2,076
  • 1 1,298

has_known_aptamer 2

  • 0 2,977
  • 1 397

has_activation_state_pdb_pair 2

  • 0 3,373
  • 1 1

tier 1

  • Tier 1.5 · 3,374 ✖

has_cryoEM 1

  • - · 3,374 ✖
id gene_symbol protein_name tier priority_score ▲ pdb_count_total alphafold_mean_pLDDT has_cryoEM has_activation_state_pdb_pair activation_state_pdb_active activation_state_pdb_inactive drug_count_approved has_known_aptamer aptamer_count_pubmed aptamer_pmids in_cev_map opentargets_top_disease_name opentargets_top_disease_score
Q9Y2C5 SLC17A4 Probable small intestine urate exporter Tier 1.5 0.878 0 83.69 0 0       0 0   0 inflammatory bowel disease 0.09896486250497885
Q9NX14 NDUFB11 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial Tier 1.5 0.86 0 77.56 0 0       0 0   1 Microphthalmia with linear skin defects syndrome 0.7364493324598024
P0DPK4 NOTCH2NLC Notch homolog 2 N-terminal-like protein C Tier 1.5 0.805 0 80.81 0 0       0 0   0 neuronal intranuclear inclusion disease 0.4999829066911242
P15260 IFNGR1 Interferon gamma receptor 1 Tier 1.5 0.804 5 66.0 0 0       1 2 33667716 1 disseminated atypical mycobacterial infection 0.5414012388034828
Q9UBT7 CTNNAL1 Alpha-catulin Tier 1.5 0.795 0 84.06 0 0       0 0   1 Abnormality of the skeletal system 0.31316995706583495
Q14031 COL4A6 Collagen alpha-6(IV) chain Tier 1.5 0.79 0 47.41 0 0       0 0   0 Dupuytren Contracture 0.5880367459451578
P36888 FLT3 Receptor-type tyrosine-protein kinase FLT3 Tier 1.5 0.788 11 75.94 0 0       1 6 41733039, 34364920, 31434881, 30237882, 29299123, 22411871 1 acute myeloid leukemia 0.8313389209288576
P37023 ACVRL1 Activin receptor type-1-like Tier 1.5 0.779 7 82.0 0 0       0 0   0 telangiectasia, hereditary hemorrhagic, type 2 0.7951167515831324
P01568 IFNA21 Interferon alpha-21 Tier 1.5 0.777 0 85.0 0 0       0 0   0 renal cell carcinoma 0.3695798546847018
P48023 FASLG Tumor necrosis factor ligand superfamily member 6 Tier 1.5 0.775 3 80.19 0 0       1 1 16581027 0 autoimmune lymphoproliferative syndrome type 1 0.6984292519156657
Q9BVX2 TMEM106C Transmembrane protein 106C Tier 1.5 0.77 0 80.81 0 0       0 0   0 prostate carcinoma 0.21737104399686757
P29017 CD1C T-cell surface glycoprotein CD1c Tier 1.5 0.77 10 88.56 0 0       0 0   0 neoplasm 0.1106047389635713
P02776 PF4 Platelet factor 4 Tier 1.5 0.77 10 75.06 0 0       1 10 33859620, 32366845, 31967847, 23847186, 23673861, 34248840, 32022468 1 systemic scleroderma 0.11523541376593864
P27037 ACVR2A Activin receptor type-2A Tier 1.5 0.769 5 83.56 0 0       0 0   1 hepatocellular carcinoma 0.4908023126074436
O14958 CASQ2 Calsequestrin-2 Tier 1.5 0.767 4 90.5 0 0       0 0   1 catecholaminergic polymorphic ventricular tachycardia 0.7718998507471558
Q9H3K6 BOLA2 BolA-like protein 2 Tier 1.5 0.765 0 92.69 0 0       0 0   1 hepatocellular carcinoma 0.08093942543094014
A0A1B0GTW7 CIROP Ciliated left-right organizer metallopeptidase Tier 1.5 0.764 0 73.44 0 0       0 0   0 heterotaxy, visceral, 12, autosomal 0.6929422132808513
Q9BZR8 BCL2L14 Apoptosis facilitator Bcl-2-like protein 14 Tier 1.5 0.76 0 62.38 0 0       0 0   0 hypothyroidism 0.33117514363294837
Q9BWF2 TRAIP E3 ubiquitin-protein ligase TRAIP Tier 1.5 0.76 1 74.94 0 0       0 0   0 Seckel syndrome 9 0.683878095944948
O15370 SOX12 Transcription factor SOX-12 Tier 1.5 0.76 0 63.0 0 0       0 0   0 type 2 diabetes mellitus 0.3277369133971199
A6NI61 MYMK Protein myomaker Tier 1.5 0.758 0 90.44 0 0       0 0   0 Carey-Fineman-Ziter syndrome 0.7790386256350393
Q16585 SGCB Beta-sarcoglycan Tier 1.5 0.75 0 76.44 0 0       0 0   0 autosomal recessive limb-girdle muscular dystrophy type 2E 0.8154766151472349
Q9GZU2 PEG3 Paternally-expressed gene 3 protein Tier 1.5 0.75 1 44.53 0 0       1 1 16595502 0 neurodegenerative disease 0.34815912577489827
P18075 BMP7 Bone morphogenetic protein 7 Tier 1.5 0.749 4 76.19 0 0       1 1 30537181 0 Inguinal hernia 0.4420059023371716
P56730 PRSS12 Neurotrypsin Tier 1.5 0.746 0 77.31 0 0       0 0   0 intellectual disability, autosomal recessive 1 0.6621935416695687
Q92956 TNFRSF14 Tumor necrosis factor receptor superfamily member 14 Tier 1.5 0.745 8 79.94 0 0       0 0   1 diffuse large B-cell lymphoma 0.5983171413833771
Q8N6D2 RNF182 E3 ubiquitin-protein ligase RNF182 Tier 1.5 0.74 0 70.25 0 0       0 0   0 periapical tissue disease 0.304701328693288
Q14246 ADGRE1 Adhesion G protein-coupled receptor E1 Tier 1.5 0.74 0 76.69 0 0       0 0   0 diabetic ketoacidosis 0.20424823130055986
P16112 ACAN Aggrecan core protein Tier 1.5 0.74 4 51.91 0 0       0 0   0 Familial osteochondritis dissecans 0.7558487616449627
Q00LT1 PRCD Photoreceptor disk component PRCD Tier 1.5 0.737 0 63.97 0 0       0 0   0 retinitis pigmentosa 0.7650522818524582
P98196 ATP11A Phospholipid-transporting ATPase IH Tier 1.5 0.735 0 82.94 0 0       0 0   1 hearing loss, autosomal dominant 84 0.5506821963658654
Q9Y4U1 MMACHC Cyanocobalamin reductase / alkylcobalamin dealkylase Tier 1.5 0.735 7 85.62 0 0       0 0   0 Methylmalonic acidemia with homocystinuria, type cblC 0.8478185420804271
P16389 KCNA2 Potassium voltage-gated channel subfamily A member 2 Tier 1.5 0.735 0 77.38 0 0       0 0   1 genetic developmental and epileptic encephalopathy 0.7513374591580034
Q9ULX7 CA14 Carbonic anhydrase 14 Tier 1.5 0.734 2 90.69 0 0       0 0   0 epilepsy 0.4397024990575866
Q99593 TBX5 T-box transcription factor TBX5 Tier 1.5 0.733 4 62.66 0 0       0 0   0 Holt-Oram syndrome 0.827317913681364
P20702 ITGAX Integrin alpha-X Tier 1.5 0.732 9 88.0 0 0       0 0   1 neurodegenerative disease 0.41708750879240836
P53539 FOSB Protein FosB Tier 1.5 0.73 12 59.12 0 0       0 0   0 neurodegenerative disease 0.22246010664492422
P09603     Tier 1.5 0.729 8 57.41 0 0       0 0   1 type 2 diabetes mellitus 0.39219340856589974
Q9P2B2 PTGFRN Prostaglandin F2 receptor negative regulator Tier 1.5 0.728 0 84.12 0 0       0 0   1 type 2 diabetes mellitus 0.48052208463481294
P22732 SLC2A5 Solute carrier family 2, facilitated glucose transporter member 5 Tier 1.5 0.728 0 90.56 0 0       0 0   1 Prolonged QT interval 0.3326218692162316
O43914 TYROBP TYRO protein tyrosine kinase-binding protein Tier 1.5 0.728 5 64.62 0 0       0 0   0 Nasu-Hakola disease 0.7323368313860329
Q9Y5C1 ANGPTL3 Angiopoietin-related protein 3 Tier 1.5 0.727 1 79.62 0 0       1 1 23770039 0 familial hypobetalipoproteinemia 2 0.6739043862507132
Q92636 NSMAF Protein FAN Tier 1.5 0.725 0 88.31 0 0       0 0   1 placental retention 0.36802220150078147
Q6MZM0 HEPHL1 Ferroxidase HEPHL1 Tier 1.5 0.72 0 89.44 0 0       0 0   0 pili torti-developmental delay-neurological abnormalities syndrome 0.40268634456935765
Q15399 TLR1 Toll-like receptor 1 Tier 1.5 0.72 6 87.19 0 0       0 0   0 asthma 0.5956884825296496
Q9NWH7 SPATA6 Spermatogenesis-associated protein 6 Tier 1.5 0.72 0 65.19 0 0       0 0   0 hypothyroidism 0.4205896274474635
P25100 ADRA1D Alpha-1D adrenergic receptor Tier 1.5 0.716 0 64.81 0 0       0 0   0 hypertension 0.6613200073424285
O60882     Tier 1.5 0.713 1 83.31 0 0       0 0   0 Hypomaturation amelogenesis imperfecta 0.7281006394540224
P79483 HLA-DRB3 HLA class II histocompatibility antigen, DR beta 3 chain Tier 1.5 0.71 2 88.38 0 0       0 0   1    
P41221 WNT5A Protein Wnt-5a Tier 1.5 0.71 0 87.69 0 0       1 4 40855286, 32693649, 22363130, 18673242 1 Robinow syndrome 0.7220360983378594

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CREATE VIEW v_targets AS
SELECT f.id, n.gene_symbol, n.protein_name, tg.tier, f.priority_score,
 f.pdb_count_total, f.alphafold_mean_pLDDT, f.has_cryoEM,
 f.has_activation_state_pdb_pair, f.activation_state_pdb_active, f.activation_state_pdb_inactive,
 f.drug_count_approved, f.has_known_aptamer, f.aptamer_count_pubmed, ap.aptamer_pmids,
 f.in_cev_map, f.opentargets_top_disease_name, f.opentargets_top_disease_score
FROM v_target_full f
LEFT JOIN target_names n ON n.target_id=f.id
LEFT JOIN targets tg ON tg.id=f.id
LEFT JOIN target_aptamer_pmids ap ON ap.target_id=f.id;