EV-Map conserved proteome (Rai & Greening 2025)

The complete EV-Map conserved molecular signature (Rai & Greening 2025, Nat Cell Biol 10.1038/s41556-025-01795-7): 182 conserved EV-hallmark proteins + 42 non-EV (lipoprotein-network) proteins. in_apt_scout = 1 if the protein is an apt-scout target (104 of the 182 EV-hallmark + 25 of the 42 non-EV are; the rest are reference-only, outside apt-scout's target universe). Source: paper Supplementary Table 7.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

gene_name
Gene symbol.
feature
EV-hallmark (conserved EV) or non-EV (lipoprotein-network).
category
EV-Map conservation category (1/2/3/Rest).
in_apt_scout
1 if this protein is an apt-scout target.
apt_scout_uniprot
apt-scout target UniProt (if in_apt_scout=1).

28 rows where category = "Category 1" and feature = "non-EV"

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in_apt_scout 2

  • 1 15
  • 0 13

feature 1

  • non-EV · 28 ✖

category 1

  • Category 1 · 28 ✖
Link rowid ▼ gene_name feature category misev_marker entrezgene_id pevs_median in_apt_scout apt_scout_uniprot
12 12 TTR non-EV Category 1   7276 26.75396118 1 P02766
16 16 TF non-EV Category 1   7018 30.26195856 1 P02787
30 30 SERPING1 non-EV Category 1   710 25.77602287 0  
31 31 SERPINF2 non-EV Category 1   5345 24.95654127 0  
33 33 SERPIND1 non-EV Category 1   3053 24.498994 1 P05546
34 34 SERPINC1 non-EV Category 1   462 26.43978997 1 P01008
37 37 SERPINA3 non-EV Category 1   12 25.78024806 1 P01011
44 44 RBP4 non-EV Category 1   5950 22.88201127 1 P02753
62 62 PON1 non-EV Category 1   5444 25.26189032 0  
66 66 PGLYRP2 non-EV Category 1   114770 24.04629121 1 Q96PD5
75 75 ORM1 non-EV Category 1   5004 25.26127749 0  
92 92 KNG1 non-EV Category 1   3827 26.91520432 1 P01042
95 95 ITIH2 non-EV Category 1   3698 27.50080873 0  
96 96 ITIH1 non-EV Category 1   3697 26.99493599 1 P19827
130 130 IGHG4 non-EV Category 1     28.24915617 0  
136 136 HPX non-EV Category 1   3263 27.09408196 0  
146 146 GC non-EV Category 1   2638 26.02859389 1 P02774
160 160 F2 non-EV Category 1   2147 25.48847607 0  
176 176 CFI non-EV Category 1   3426 23.0706348 0  
188 188 C9 non-EV Category 1   735 24.25962094 1 P02748
189 189 C7 non-EV Category 1   730 23.59117526 1 P10643
190 190 C6 non-EV Category 1   729 23.1444777 1 P13671
196 196 AZGP1 non-EV Category 1   563 24.56888932 1 P25311
207 207 APOH non-EV Category 1   350 26.40648294 1 P02749
208 208 APOB non-EV Category 1   338 27.32785537 0  
209 209 APOA4 non-EV Category 1   337 25.8536907 0  
215 215 AMBP non-EV Category 1   259 26.03843225 0  
217 217 AHSG non-EV Category 1   197 25.54351737 0  

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CREATE TABLE ev_map_conserved (gene_name TEXT, feature TEXT, category TEXT,
             misev_marker TEXT, entrezgene_id TEXT, pevs_median TEXT,
             in_apt_scout INTEGER, apt_scout_uniprot TEXT);