scout

apt-scout is built around a hand-curated, verbatim-verified catalogue of aptamer–target binding affinities (K_d) — not a re-hosted aggregation. Every K_d is read back from its primary publication, stored with the exact source sentence, and labelled by measurement type (intrinsic equilibrium vs apparent/avidity); a verbatim re-verification found that ~40–50% of reported K_d values in existing aggregated aptamer collections are in fact apparent/avidity, not comparable. This curated K_d layer is then linked to a target-context profile of ~7,177 human proteins (the layers below are harvested from public databases and labelled as such).

apt-scout is an automated catalogue of 7,177 human protein targets, each evaluated across a five-layer schema (structure / modification / interaction / expression / disease) to prioritise targets for affinity-reagent (aptamer, antibody, ASO, small-molecule) design — with explicit annotation of activation-state-selective surfaces.

How the data was built (provenance): values are mechanically harvested from public databases — PDB / AlphaFold / EMDB (structure), UniProt (modifications), Open Targets / ChEMBL / PubMed / Aptagen / HPA (interaction), Human Protein Atlas / Vesiclepedia / ExoCarta / EV-Map (expression), Open Targets (disease). The raw source response is stored per target in each layer's raw_json column, so every value is traceable to its origin. Activation-state PDB pairs are a human-curated list of real PDB structures. No free-text was generated by an LLM in these layers.

How to verify any value: open a target, then check its source — e.g. PDB IDs at rcsb.org, UniProt at uniprot.org, expression at proteinatlas.org, disease at platform.opentargets.org. The raw_json column shows the exact upstream record (including PubMed queries + PMIDs).

Tiers: Tier 1 = 3,300 PDB-anchored targets; Tier 1.5 = 3,874 AlphaFold-confident targets; plus 3 controls.

Completeness / known limitations (transparent): some fields are not yet fully populated — ppi_count is pending; OMIM / ClinVar counts are blank in this production snapshot (held in a separate reference cohort); AlphaFold pLDDT is missing for 653 targets. A data-quality audit (incl. inter-rater verification) is in progress.

JSON API: append .json to any table or query. License: CC BY 4.0.